Weight loss reduces dyspnea on exertion in obese women

Respiratory Physiology and Neurobiology

Volumn 204, Issue , 2014, Pages 86-92

  Bernhardt, Vipa ^a   Babb, Tony G ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Body composition; Exercise; Pulmonary function; Shortness of breath; Work of breathing

Indexed keywords

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CARDIORESPIRATORY FITNESS; CHEST CIRCUMFERENCE; CYCLING; DYSPNEA; EXERCISE; EXERCISE TEST; EXPIRATORY RESERVE VOLUME; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL RESIDUAL CAPACITY; HIP CIRCUMFERENCE; HUMAN; HUMAN EXPERIMENT; INSPIRATORY CAPACITY; LEAN BODY WEIGHT; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG GAS EXCHANGE; LUNG MINUTE VOLUME; LUNG VENTILATION; NECK CIRCUMFERENCE; NORMAL HUMAN; OBESITY; OXYGEN BREATHING; SPIROMETRY; TOTAL LUNG CAPACITY; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT REDUCTION; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

ADULT; BICYCLING; BODY COMPOSITION; DYSPNEA; FEMALE; HUMANS; OBESITY; PHYSICAL EXERTION; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84910628831     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2014.09.004     Document Type: Article

References (51)

1. Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-1994. Vital and health statistics. Ser. 1, Programs and Collection Procedures, pp. 1-407.
2. American Thoracic Society Standardization of Spirometry 1994 Update. Am. J. Respir. Crit. Care Med. 1995, 152:1107-1136.
3. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Am. J. Clin. Nutr. 1998, 68:899-917.
4. Aaron S.D., Fergusson D., Dent R., Chen Y., Vandemheen K.L., Dales R.E. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004, 125:2046-2052.
5. Azagury D.E., Lautz D.B. Obesity overview: epidemiology, health and financial impact, and guidelines for qualification for surgical therapy. Gastrointest. Endosc. Clin. N. Am. 2011, 21:189-201.
6. Babb T.G., DeLorey D.S., Wyrick B.L., Gardner P.P. Mild obesity does not limit change in end-expiratory lung volume during cycling in young women. J. Appl. Physiol. 2002, 92:2483-2490.
7. Babb T.G., Korzick D., Meador M., Hodgson J.L., Buskirk E.R. Ventilatory response of moderately obese women to submaximal exercise. Int. J. Obes. 1991, 15:59-65.
8. Babb T.G., Ranasinghe K.G., Comeau L.A., Semon T.L., Schwartz B. Dyspnea on exertion in obese women: association with an increased oxygen cost of breathing. Am. J. Respir. Crit. Care Med. 2008, 178:116-123.
9. Babb T.G., Wyrick B.L., DeLorey D.S., Chase P.J., Feng M.Y. Fat distribution and end-expiratory lung volume in lean and obese men and women. Chest 2008, 134:704-711.
10. Babb T.G., Wyrick B.L., Chase P.J., Delorey D.S., Rodder S.G., Feng M.Y., Ranasinghe K.G. Weight loss via diet and exercise improves exercise breathing mechanics in obese men. Chest 2011, 140:454-460.
11. Bassett J.T., Bernhardt V., Lorenzo S., Moran R.B., Haller S.F., Pineda J.N., Babb T.G. Peak oxygen uptake differs between obese women with vs. without dyspnea on exertion. Med. Sci. Sports Exerc. 2013, 45(5S):401.
12. Bernhardt V., Babb T.G. Respiratory symptom perception differs in obese women with strong or mild breathlessness during constant-load exercise. Chest 2014, 145:361-369.
13. Bernhardt V., Lorenzo S., Moran R.B., Bassett J.T., Haller S.F., Pineda J.N., Babb T.G. Oxygen cost of breathing does not differ between women with vs. without dyspnea on exertion. Med. Sci. Sports Exerc. 2013, 45(5S):292.
14. Bernhardt V., Moran R.B., Bassett J.T., Lorenzo S., Pineda J.N., Babb T.G. Weight loss reduces dyspnea on exertion in obese women independent of improvement in respiratory function. Am. J. Respir. Crit. Care Med. 2014, 189:A5386.
15. Bernhardt V., Wood H.E., Moran R.B., Babb T.G. Dyspnea on exertion in obese men. Respir. Physiol. Neurobiol. 2013, 185:241-248.
16. Borg G.A. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 1982, 14:377-381.
17. Chan P.Y., Davenport P.W. Respiratory-related evoked potential measures of respiratory sensory gating. J. Appl. Physiol. 2008, 105:1106-1113.
18. Chan P.Y., von Leupoldt A., Bradley M.M., Lang P.J., Davenport P.W. The effect of anxiety on respiratory sensory gating measured by respiratory-related evoked potentials. Biol. Psychol. 2012, 91:185-189.
19. Davenport P., Reep R. Cerebral cortex and respiration. Regulation of Breathing 1995, 362-388. Dekker, New York, NY. J. Dempsey, A. Pack (Eds.).
20. Davenport P.W., Chan P.Y., Zhang W., Chou Y.L. Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials. J. Appl. Physiol. 2007, 102(1985):276-285.
21. De Lorenzo A., Petrone-De Luca P., Sasso G.F., Carbonelli M.G., Rossi P., Brancati A. Effects of weight loss on body composition and pulmonary function. Respiration 1999, 66:407-412.
22. DeLorey D.S., Wyrick B.L., Babb T.G. Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men. Int. J. Obes. (Lond.) 2005, 29:1039-1047.
23. Dempsey J.A., Reddan W., Rankin J., Balke B. Alveolar-arterial gas exchange during muscular work in obesity. J. Appl. Physiol. 1966, 21:1807-1814.
24. Donnelly J.E., Blair S.N., Jakicic J.M., Manore M.M., Rankin J.W., Smith B.K., American College of Sports M. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med. Sci. Sports Exerc. 2009, 41:459-471.
25. El-Gamal H., Khayat A., Shikora S., Unterborn J.N. Relationship of dyspnea to respiratory drive and pulmonary function tests in obese patients before and after weight loss. Chest 2005, 128:3870-3874.
26. el-Manshawi A., Killian K.J., Summers E., Jones N.L. Breathlessness during exercise with and without resistive loading. J. Appl. Physiol. 1986, 61(1985):896-905.
27. Emirgil C., Sobol B.J. The effects of weight reduction on pulmonary function and the sensitivity of the respiratory center in obesity. Am. Rev. Respir. Dis. 1973, 108:831-842.
28. Gibson G.J. Obesity, respiratory function and breathlessness. Thorax 2000, 55(Suppl 1):S41-S44.
29. Hakala K., Mustajoki P., Aittomaki J., Sovijarvi A.R. Effect of weight loss and body position on pulmonary function and gas exchange abnormalities in morbid obesity. Int. J. Obes. Relat. Metab. Disord. 1995, 19:343-346.
30. Jones R.L., Nzekwu M.M. The effects of body mass index on lung volumes. Chest 2006, 130:827-833.
31. Karason K., Lindroos A.K., Stenlof K., Sjostrom L. Relief of cardiorespiratory symptoms and increased physical activity after surgically induced weight loss: results from the Swedish obese subjects study. Arch. Intern. Med. 2000, 160:1797-1802.
32. Kenchaiah S., Evans J.C., Levy D., Wilson P.W., Benjamin E.J., Larson M.G., Kannel W.B., Vasan R.S. Obesity and the risk of heart failure. N. Engl. J. Med. 2002, 347:305-313.
33. Lorenzo S., Babb T.G. Quanitification of cardiorespiratory fitness in healthy nonobese and obese men and women. Chest 2012, 141(4):1031-1039.
34. Moran R.B., Bernhardt V., Lorenzo S., Bassett J.T., Haller S.F., Pineda J.N., Babb T.G. Pulmonary function does not differ between obese women with and without dyspnea on exertion. Med. Sci. Sports Exerc. 2013, 45(5S):401.
35. O'Donnell C.P., Holguin F., Dixon A.E. Pulmonary physiology and pathophysiology in obesity. J. Appl. Physiol. 2010, 108(1985):197-198.
36. Ofir D., Laveneziana P., Webb K.A., O'Donnell D.E. Ventilatory and perceptual responses to cycle exercise in obese women. J. Appl. Physiol. 2007, 102(1985):2217-2226.
37. Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of childhood and adult obesity in the United States, 2011-2012. J. Am. Med. Assoc. 2014, 311:806-814.
38. Pelosi P., Croci M., Ravagnan I., Tredici S., Pedoto A., Lissoni A., Gattinoni L. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth. Analg. 1998, 87:654-660.
39. Pineda J.N., Bernhardt V., Lorenzo S., Moran R.B., Bassett J.T., Haller S.F., Babb T.G. Similar body composition and fat distribution between obese women with vs. without dyspnea on exertion. Med. Sci. Sports Exerc. 2013, 45(5S):294.
40. Poulain M., Doucet M., Major G.C., Drapeau V., Series F., Boulet L.P., Tremblay A., Maltais F. The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies. Can. Med. Assoc. J. 2006, 174:1293-1299.
41. Santesson J., Nordenstrom J. Pulmonary function in extreme obesity. Influence of weight loss following intestinal shunt operation. Acta Chir. Scand. Suppl. 1978, 482:36-40.
42. Sin D.D., Jones R.L., Man S.F. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch. Intern. Med. 2002, 162:1477-1481.
43. Steele R.M., Finucane F.M., Griffin S.J., Wareham N.J., Ekelund U. Obesity is associated with altered lung function independently of physical activity and fitness. Obesity 2009, 17:578-584.
44. Thomas P.S., Cowen E.R., Hulands G., Milledge J.S. Respiratory function in the morbidly obese before and after weight loss. Thorax 1989, 44:382-386.
45. Tsai H.W., Chan P.Y., von Leupoldt A., Davenport P.W. The impact of emotion on the perception of graded magnitudes of respiratory resistive loads. Biol. Psychol. 2013, 93:220-224.
46. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease. Nature 2006, 444:875-880.
47. von Leupoldt A., Vovk A., Bradley M.M., Lang P.J., Davenport P.W. Habituation in neural processing and subjective perception of respiratory sensations. Psychophysiology 2011, 48:808-812.
48. Wadstrom C., Muller-Suur R., Backman L. Influence of excessive weight loss on respiratory function. A study of obese patients following gastroplasty. Eur. J. Surg.-Acta Chir. 1991, 157:341-346.
49. Wei Y.F., Tseng W.K., Huang C.K., Tai C.M., Hsuan C.F., Wu H.D. Surgically induced weight loss, including reduction in waist circumference, is associated with improved pulmonary function in obese patients. Surg. Obes. Relat. Dis.: Off. J. Am. Soc. Bariatr. Surg. 2011, 7:599-604.
50. Whipp B.J., Davis J.A. The ventilatory stress of exercise in obesity. Am. Rev. Respir. Dis. 1984, 129:S90-S92.
51. Wood H.E., Semon T.L., Comeau L.A., Schwartz B., MacDougall R.M., Klocko M.N., Babb T.G. The ventilatory response to exercise does not differ between obese women with and without dyspnea on exertion. Adv. Exp. Med Biol. 2008, 605:514-518.