Graft patency after off-pump coronary artery bypass surgery is inferior even with identical heparinization protocols: Results from the Danish On-pump Versus Off-pump Randomization Study (DOORS)

Journal of Thoracic and Cardiovascular Surgery

Volumn 148, Issue 5, 2014, Pages 1812-1819.e2

  Houlind, Kim ^a,b   Fenger Grøn, Morten ^c   Holme, Susanne J ^d   Kjeldsen, Bo J ^e   Madsen, Susanne N ^f   Rasmussen, Bodil S ^f   Jepsen, Mogens H ^a   Ravkilde, Jan ^a,f   Aaroe, Jens ^f   Hansen, Peter Riis ^d   Hansen, Henrik Steen ^e   Mortensen, Poul Erik ^e  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

^f AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; COUMARIN DERIVATIVE; HEPARIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROTAMINE SULFATE; ANTICOAGULANT AGENT; HEPARIN ANTAGONIST; PROTAMINE;

AGED; ANASTOMOSIS; ANGIOCARDIOGRAPHY; ARTERIOTOMY; ARTICLE; BLOOD CLOTTING TIME; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY SURGERY; FEMALE; FOLLOW UP; GRAFT PATENCY; HEART INFARCTION; HEPARINIZATION; HUMAN; INTERMETHOD COMPARISON; INTERNAL MAMMARY ARTERY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); OFF PUMP CORONARY SURGERY; ON PUMP CORONARY SURGERY; POSTOPERATIVE COMPLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REOPERATION; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY BLOOD VESSEL; DENMARK; DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SURGERY; TIME; TREATMENT OUTCOME; VASCULAR PATENCY;

AGED; ANTICOAGULANTS; CARDIOPULMONARY BYPASS; CORONARY ANGIOGRAPHY; CORONARY ARTERY BYPASS; CORONARY ARTERY BYPASS, OFF-PUMP; CORONARY VESSELS; DENMARK; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEPARIN; HEPARIN ANTAGONISTS; HUMANS; MALE; PROTAMINES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; VASCULAR PATENCY;

EID: 84910144946     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2014.02.024     Document Type: Article

References (32)

1. D.N. Wijeysundera, W.S. Beattie, G. Djaiani, V. Rao, M.A. Borger, and K. Karkouti Off-pump coronary artery surgery for reducing mortality and morbidity: metaanalysis of randomized and observational studies J Am Coll Cardiol 46 2005 872 882
2. A. Lamy, P.J. Devereaux, D. Prabhakaran, D.P. Taggart, S. Hu, E. Ernesto Paolasso for the CORONARY Investigators Off-pump or on-pump coronary-artery bypass grafting at 30 days N Engl J Med 366 2012 1489 1497
3. A.L. Shroyer, F.L. Grover, B. Hattler, J.F. Collins, G.O. McDonald, and E. Kozora On-pump versus off-pump coronary-artery bypass surgery N Engl J Med 361 2009 1827 1837
4. K. Houlind, B.J. Kjeldsen, S.N. Madsen, B.S. Rasmussen, S.J. Holme, P.H. Nielsen DOORS Study Group On-pump versus off-pump coronary artery bypass surgery in elderly patients: results from the Danish on-pump versus off-pump randomization study Circulation 125 2012 2431 2439
5. N. Nesher, I. Frolkis, M. Vardi, N. Sheinberg, I. Bakir, and F. Caselman Higher levels of serum cytokines and myocardial tissue markers during on-pump versus off-pump coronary artery bypass surgery J Card Surg 21 2006 395 402
6. F. Onorati, A.S. Rubino, S. Nucera, D. Foti, V. Sica, and F. Santini Offpump coronary artery bypass surgery versus standard linear or pulsatile cardiopulmonary bypass: endothelial activation and inflammatory response Eur J Cardiothorac Surg 37 2010 897 904
7. Y.J. Gu, M.A. Mariani, W. van Oeveren, J.G. Grandjean, and P.W. Boonstra Reduction of the inflammatory response in patients undergoing minimally invasive coronary artery bypass grafting Ann Thorac Surg 65 1998 420 424
8. G.D. Angelini, F.C. Taylor, B.C. Reeves, and R. Ascione Early and midterm outcome after offpump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials Lancet 359 2002 1194 1199
9. H.M. Nathoe, D. Dijk, E.W.L. Jansen, W.J.L. Suyker, J.C. Diephuis, and W.J. Boven A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients N Engl J Med 348 2003 394 402
10. J.D. Puskas, W.H. Williams, P.G. Duke, J.R. Staples, K.E. Glas, and J.J. Marshall Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting J Thorac Cardiovasc Surg 125 2003 797 808
11. N.E. Khan, A. De Souza, R. Mister, M. Flather, J. Clague, and S. Davies A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery N Engl J Med 350 2004 21 28
12. D. van Dijk, A.P. Nierich, E.W.L. Jansen, H.M. Nathoe, W.J.L. Suyker, J.C. Diephuis for the Octopus Study Group Early outcome after off-pump versus on-pump coronary bypass surgery: results from a randomized study Circulation 104 2001 1761 1766
13. J.D. Puskas, W.H. Williams, E.M. Mahoney, P.R. Huber, P.C. Block, and P.G. Duke Off-pump vs conventional coronary artery bypass grafting: early and 1 year graft patency, cost, and quality-of-life outcomes. A randomized trial JAMA 291 2004 1841 1849
14. Z. Straka, P. Widimsky, K. Jirasek, P. Stros, J. Votava, and T. Vanek Off-pump versus on-pump coronary surgery: final results from a prospective randomized study PRAGUE-4 Ann Thorac Surg 77 2004 789 793
15. K. Houlind, B.J. Kjeldsen, S.N. Madsen, B.S. Rasmussen, S.J. Holme, P.A. Pallesen DOORS Study Group OPCAB surgery is cost-effective for elderly patients Scand Cardiovasc J 47 2013 185 192
16. B. Hattler, J.C. Messenger, A.L. Shroyer, J.F. Collins, S.J. Haugen, J.A. Garcia for the Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group Off-pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularization results from the Veterans Affairs Randomized On/Off Bypass (ROOBY) trial Circulation 125 2012 2827 2835
17. C.H. Møller, M.J. Perko, J.T. Lund, L.W. Andersen, H. Kelbæk, and J.K. Madsen Graft patency after off-pump versus on-pump coronary artery surgery in high-risk patients Scand Cardiovasc J 44 2010 161 167
18. M.S. Uva, S. Cavaco, A.G. Oliveira, F. Matias, C. Silva, and A. Mesquita Early graft patency after off-pump and on-pump coronary bypass surgery: a prospective randomized study Eur Heart J 31 2010 2492 2499
19. R. Ascione, S. Williams, C.T. Lloyd, T. Sundaramoorthi, A.A. Pitsis, and G.D. Angelini Reduced postoperative blood loss and transfusion requirement after beating-heart coronary operations: a prospective randomized study Ann Thorac Surg 68 1999 493 498
20. L.A. Harker, T.W. Malpass, H.E. Branson, E.A. Hessel, and S.J. Slichter Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release Blood 56 1980 824 834
21. Z.N. Kon, M.H. Kwon, M.J. Collins, S. Kallam, R. Sangrampurkar, and T. Ozeki Off-pump coronary artery bypass leads to a regional hypercoagulable state not detectable using systemic markers Innovations (Phila) 1 2006 232 238
22. M.A. Mariani, Y.J. Gu, P.W. Boonstra, J.G. Grandjean, W. van Oeveren, and T. Ebels Procoagulant activity after off-pump coronary operation: is the current anticoagulation adequate? Ann Thorac Surg 67 1999 1370 1375
23. V.H. Thourani, and R.A. Guyton Graft patency after off-pump coronary artery bypass surgery Circulation 125 2012 2806 2808
24. S.V. Deo, S.M. Dunlay, I.K. Shah, S.E. Altarabsheh, P.J. Erwin, and B.A. Boilson Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis J Card Surg 28 2013 109 116
25. K. Houlind, B.J. Kjeldsen, S.N. Madsen, B.S. Rasmussen, S.J. Holme, T.A. Schmidt DOORS Study Group The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomization Study (DOORS) Trials 10 2009 47 55
26. G.M. FitzGibbon, A.J. Leach, H.P. Kafka, and W.J. Keon Coronary bypass graft fate: long term angiographic study J Am Coll Cardiol 17 1991 1075 1080
27. F. Alessandrini, M. Gaudino, F. Glieca, N. Luciani, F.L. Piancone, and M. Zimarino Lesions of the target vessel during minimally invasive myocardial revascularization Ann Thorac Surg 64 1997 1349 1353
28. H. Nakajima, J. Kobayashi, K. Toda, T. Fujita, Y. Shimahara, and Y. Kasahara Angiographic evaluation of flow distribution in sequential and composite grafts for three-vessel disease Eur J Cardiothorac Surg 41 2012 763 769
29. H. Hangler, L. Mueller, E. Rottmann, H. Antretter, and K. Pfaller Shunt or snare: coronary endothelial damage due to hemostatic devices for beating heart coronary surgery Ann Thorac Surg 86 2008 1873 1877
30. F.D. Loop, B.W. Lytle, D.M. Cosgrove, R.W. Stewart, M. Goormastic, and G.W. Williams Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events N Engl J Med 314 1986 1 6
31. B.F. Buxton, P. Ruengsakulrach, J. Fuller, A. Rosalion, C.M. Reid, and J. Tatoulis The right internal thoracic artery graft - benefits of grafting the left coronary system and native vessels with a high grade stenosis Eur J Cardiothorac Surg 18 2000 255 261
32. R. Sørensen, S.Z. Abildstrøm, P.R. Hansen, A. Hvelplund, C. Andersson, and M. Charlot Efficacy of post-operative clopidogrel treatment in patients revascularized with coronary artery bypass grafting after myocardial infarction J Am Coll Cardiol 57 2011 1202 1209