Metformin safety in the management of gestational diabetes

Endocrine Practice

Volumn 20, Issue 10, 2014, Pages 1022-1031

  Marques, Pedro ^a   Carvalho, Maria Raquel ^b   Pinto, Luísa ^b   Guerra, Sílvia ^b  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

BMI = body mass index; DM = diabetes mellitus; FPG = fasting plasma glucose; GDM = gestational diabetes mellitus; HbA1C = glycated hemoglobin; IFG = impaired fasting glucose; IGT = impaired glucose tolerance; LGA = large for gestational age; NICU = neonatal intensive care unit; OGTT = oral glucose tolerance test; SGA = small for gestational age; T2DM = type 2 diabetes mellitus

Indexed keywords

INSULIN; ISOPHANE INSULIN; METFORMIN;

ABORTION; ADULT; ARTICLE; BIRTH DEFECT; BIRTH INJURY; CESAREAN SECTION; CLINICAL ARTICLE; CLINICAL EVALUATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; DIET; DRUG SAFETY; FEMALE; HUMAN; LARGE FOR GESTATIONAL AGE; MACROSOMIA; NEWBORN INTENSIVE CARE; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PERINATAL DEATH; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREMATURITY; RETROSPECTIVE STUDY; SIDE EFFECT; SMALL FOR DATE INFANT; STATISTICAL ANALYSIS; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 84910144910     PISSN: 1530891X     EISSN: 19342403     Source Type: Journal    
DOI: 10.4158/EP14018.OR     Document Type: Article

References (33)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013; 36 Suppl 1: S1-S110
2. Dabelea D, Snell-Bergeon JK, Hartsfield CL, et al. Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort. Diabetes Care. 2005; 28: 579-584
3. Hunt KJ, Schuller KL. The increasing prevalence of diabetes in pregnancy. Obstet Gynecol Clin North Am. 2007; 34: 173-199
4. Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286: 2516-2518
5. Tertti K, Ekblad U, Vahlberg T, Rönnemaa T. Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective, case-control study. Rev Diabet Stud. 2008;5: 95-101
6. Bowers K, Laughon SK, Kiely M, Brite J, Chen Z, Zhang C. Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: variations by race/ethnicity. Diabetologia. 2013;56: 1263-1271
7. Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-Analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research. Ann Intern Med. 2013;159: 123-129
8. Ferrara A, Kahn HS, Quesenberry CP, Riley C, Hedderson MM. An increase in the incidence of gestational diabetes mellitus: Northern California, 1991-2000. Obstet Gynecol. 2004;103: 526-533
9. Dhulkotia JS, Ola B, Fraser R, Farrell T. Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis. Am J Obstet Gynecol. 2010;203: 457.e1-9
10. HAPO Study Cooperative Research Group Metzger BE, Lowe LP, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358: 1991-2002
11. Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008;358: 2003-2015
12. Crowther CA, Hiller JE, Moss JR, et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005;352: 2477-2486
13. Balani J, Hyer SL, Rodin DA, Shehata H. Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. Diabet Med. 2009;26: 798-802
14. Gui J, Liu Q, Feng L. Metformin vs insulin in the management of gestational diabetes: a meta-Analysis. PLoS ONE. 2013;8: e64585
15. Wensel TM. Role of metformin in the treatment of gestational diabetes. Ann Pharmacother. 2009;43: 939-943
16. Nanovskaya TN, Nekhayeva IA, Patrikeeva SL, Hankins GD, Ahmed MS. Transfer of metformin across the dually perfused human placental lobule. Am J Obstet Gynecol. 2006;195: 1081-1085
17. Silverman B, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers: relationship to fetal hyperinsulinism. Diabetes Care. 1995;18: 611-617
18. Niromanesh S, Alavi A, Sharbaf FR, Amjadi N, Moosavi S, Akbari S. Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial. Diabetes Res Clin Pract. 2012;98: 422-429
19. Ijäs H, Vääräsmäki M, Morin-Papunen L, et al. Metformin should be considered in the treatment of gestational diabetes: a prospective randomized study. BJOG. 2011;118: 880-885
20. Mesdaghinia E, Samimi M, Homaei Z, Saberi F, Moosavi SG, Yaribakht M. Comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomized blinded trial. Int J Prev Med. 2013;4: 327-333
21. Rai L, Meenakshi D, Kamath A. Metformin-A convenient alternative to insulin for Indian women with diabetes in pregnancy. Indian J Med Sci. 2009;63: 491-497
22. Goh JE, Sadler L, Rowan J. Metformin for gestational diabetes in routine clinical practice. Diabet Med. 2011;28: 1082-1087
23. Tertti K, Ekblad U, Koskinen P, Vahlberg T, Rönnemaa T. Metformin vs. Insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. Diabetes Obes Metab. 2013;15: 246-251
24. Spaulonci CP, Bernardes LS, Trindade TC, Zugaib M, Francisco RP. Randomized trial of metformin vs insulin in the management of gestational diabetes. Am J Obstet Gynecol. 2013;209: 34.e1-7
25. International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33: 676-682
26. Dores J, Almeida MC, Vicente L, Paiva, S. Relatório de Consenso sobre a Diabetes e Gravidez. 2011. Available at: http://www.dgs.pt/documentos-e-publicacoes/relatorio-deconsenso-sobre-diabetes-e-gravidez-pdf.aspx
27. Landon MB, Spong CY, Thom E, et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009; 361: 1339-1348
28. Cheung NW. The management of gestational diabetes. Vasc Health Risk Manag. 2009;5: 153-164
29. Blumer I, Hadar E, Hadden DR, et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98: 4227-4249
30. Raio L, Ghezzi F, Di Naro E, et al. Perinatal outcome of fetuses with a birth weight greater than 4500 g: an analysis of 3356 cases. Eur J Obstet Gynecol Reprod Biol. 2003; 109: 160-165
31. Dempsey JC, Buder CL, Sorensen TK, et al. A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitus. Diabetes Res Clin Pract. 2004;66: 203-215
32. Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes. Diabet Med. 2004;21: 103-113
33. Moore LE, Briery CM, Clokey D, et al. Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. J Reprod Med. 2007; 52: 1011-1015