Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat

Neuropsychiatric Disease and Treatment

Volumn 10, Issue , 2014, Pages 2139-2145

  Gao, Fei ^a   Gao, Ying ^b   Liu, Yang Feng ^c   Wang, Li ^a   Li, Ya Jun ^a  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c Department of Pharmacy No451 Hospital of Peoples Liberation Army   (China)

Author keywords

Memory impairment; Neuroprotection; Oxidative stress; Pilocarpine; Status epilepticus

Indexed keywords

BERBERINE; CATALASE; GLUTATHIONE; MALONALDEHYDE; PILOCARPINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; ENZYME ACTIVITY; EPILEPTIC STATE; HIPPOCAMPAL CA1 REGION; LATENT PERIOD; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; STAINING;

EID: 84910144594     PISSN: None     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S73210     Document Type: Article

References (35)

1. Dua T, de Boer HM, Prilipko LL, Saxena S. Epilepsy care in the world: results of an ILAE/IBE/WHO global campaign against epilepsy survey. Epilepsia. 2006;47(7):1225-1231.
2. Kapur N. Transient epileptic amnesia-a clinical update and a reformulation. J Neurol Neurosurg Psychiatry. 1993;56(11):1184-1190.
3. Thompson PJ, Trimble MR. Anticonvulsant serum levels: relationship to impairments of cognitive functioning. J Neurol Neurosurg Psychiatry. 1983;46(3):227-233.
4. Jambaqué I, Dellatolas G, Dulac O, Ponsot G, Signoret JL. Verbal and visual memory impairment in children with epilepsy. Neuropsychologia. 1993;31(12):1321-1337.
5. Ortinski P, Meador KJ. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 2004;5 Suppl 1:S60-S65.
6. Curia G, Longo D, Biagini G, Jones RS, Avoli M. The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods. 2008;172(2): 143-157.
7. de Freitas RL, Santos IM, de Souza GF, Tome Ada R, Saldanha GB, de Freitas RM. Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. Brain Res Bull. 2010;81(4-5):505-509.
8. Sudha K, Rao AV, Rao A. Oxidative stress and antioxidants in epilepsy. Clin Chim Acta. 2001;303(1-2):19-24.
9. Kamida T, Fujiki M, Ooba H, Anan M, Abe T, Kobayashi H. Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. Seizure. 2009; 18(1):71-75.
10. Shin EJ, Jeong JH, Chung YH, et al. Role of oxidative stress in epileptic seizures. Neurochem Int. 2011;59(2):122-137.
11. Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res. 2008;22(8):999-1012.
12. Hong JS, Chu YK, Lee H, et al. Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase-9 activity following transient global cerebral ischemia. J Neurosci Res. 2012;90(2):489-497.
13. Zhang X, Wang C, Li Y, et al. Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: Up-regulated pAkt, pGSK and pCREB, down-regulated NF-B expression, ameliorated BBB permeability. Brain Res. 2012;1459:61-70.
14. Gu L, Li N, Yu W, et al. Berberine reduces rat intestinal tight junction injury induced by ischemia-reperfusion associated with the suppression of inducible nitric oxide synthesis. Am J Chin Med. 2013;41(6):1297-1312.
15. Bhutada P, Mundhada Y, Bansod K, Dixit P, Umathe S, Mundhada D. Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav. 2010;18(3):207-210.
16. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972;32(3):281-294.
17. Chu K, Jung KH, Lee ST, et al. Erythropoietin reduces epileptogenic processes following status epilepticus. Epilepsia. 2008; 49(10):1723-1732.
18. Ruiz-Larrea MB, Leal AM, Liza M, Lacort M, de Groot H. Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes. Steroids. 1994;59(6):383-388.
19. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-126.
20. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247(10):3170-3175.
21. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882-888.
22. Schmued LC, Hopkins KJ. Fluoro-jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol Pathol. 2000;28(1):91-99.
23. Liu YF, Gao F, Li XW, et al. The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Neurochem Res. 2012;37(8):1670-1680.
24. Saad K, Hammad E, Hassan AF, Badry R. Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy. Int J Neurosci. 2014;124(3):181-186.
25. Freitas RM, Vasconcelos SM, Souza FC, Viana GS, Fonteles MM. Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. FEBS J. 2005;272(6):1307-1312.
26. Freitas RM, Sousa FC, Vasconcelos SM, Viana GS, Fonteles MM. Pilocarpine-induced status epilepticus in rats: lipid peroxidation level, nitrite formation, GABAergic and glutamatergic receptor alterations in the hippocampus, striatum and frontal cortex. Pharmacol Biochem Behav. 2004;78(2):327-332.
27. Liang LP, Patel M. Seizure-induced changes in mitochondrial redox status. Free Radic Biol Med. 2006;40(2):316-322.
28. Keller JN, Schmitt FA, Scheff SW, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 2005;64(7):1152-1156.
29. Frantseva MV, Velazquez JL, Hwang PA, Carlen PL. Free radical production correlates with cell death in an in vitro model of epilepsy. Eur J Neurosci. 2000;12(4):1431-1439.
30. Ancelin ML, Christen Y, Ritchie K. Is antioxidant therapy a viable alternative for mild cognitive impairment? Examination of the evidence. Dement Geriatr Cogn Disord. 2007;24(1):1-19.
31. Biessels GJ, Kamal A, Ramakers GM, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes. 1996;45(9):1259-1266.
32. Fukui K, Onodera K, Shinkai T, Suzuki S, Urano S. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann N Y Acad Sci. 2001;928: 168-175.
33. Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci. 2000;23(11):542-549.
34. Hu J, Chai Y, Wang Y, et al. PI3K p55γpromoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. Eur J Pharmacol. 2012;674(2-3):132-142.
35. Wang F, Zhao G, Cheng L, Zhou HY, Fu LY, Yao WX. Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res. 2004;999(1):91-97.