Determination of peptide content and purity of DOTA-peptides by metal ion titration and UPLC: An alternative method to monitor quality of DOTA-peptides

Journal of Radioanalytical and Nuclear Chemistry

Volumn 302, Issue 2, 2014, Pages 825-830

  Breeman, Wouter A P ^a   Chan, Ho Sze ^a   de Blois, Erik ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

177Lu DOTA TATE; DOTA peptide purity and content; Lutetium 177; Metal ion; UPLC

Indexed keywords

DOTA TATE; DOTA TATE LU 177; METAL ION; PEPTIDE DERIVATIVE; TETRAXETAN; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG IMPURITY; DRUG PURITY; DRUG QUALITY; DRUG SCREENING; ISOTOPE LABELING; METAL ION TITRATION; PEPTIDE ANALYSIS; PROTEIN CONTENT; QUALITY CONTROL; RADIATION DETECTION; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

EID: 84910117641     PISSN: 02365731     EISSN: 15882780     Source Type: Journal    
DOI: 10.1007/s10967-014-3248-1     Document Type: Article

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