메뉴 건너뛰기




Volumn 174, Issue 1-2, 2014, Pages 116-126

Vaccination with recombinant 4×M2e.HSP70c fusion protein as a universal vaccine candidate enhances both humoral and cell-mediated immune responses and decreases viral shedding against experimental challenge of H9N2 influenza in chickens

Author keywords

Chicken; H9N2; HSP70c; Influenza A universal vaccine; M2e

Indexed keywords

GAMMA INTERFERON; HEAT SHOCK PROTEIN 70; INFLUENZA VACCINE; INTERLEUKIN 4; MATRIX PROTEIN; RECOMBINANT MATRIX PROTEIN 2E HEAT SHOCK PROTEIN 70C FUSION PROTEIN; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; HYBRID PROTEIN; INACTIVATED VACCINE;

EID: 84909982991     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2014.09.009     Document Type: Article
Times cited : (26)

References (53)
  • 1
    • 0141566349 scopus 로고    scopus 로고
    • Report on avian influenza in the Eastern Hemisphere during 1997-2002
    • Alexander D.J. Report on avian influenza in the Eastern Hemisphere during 1997-2002. Avian Dis. 2003, 47:792-797.
    • (2003) Avian Dis. , vol.47 , pp. 792-797
    • Alexander, D.J.1
  • 2
    • 0029127770 scopus 로고
    • Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96
    • Arnold D., Raath S., Rammensee H.G., Schild H. Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J. Exp. Med. 1995, 182:885.
    • (1995) J. Exp. Med. , vol.182 , pp. 885
    • Arnold, D.1    Raath, S.2    Rammensee, H.G.3    Schild, H.4
  • 3
    • 0141789694 scopus 로고    scopus 로고
    • Evaluation of pathogenic potential of avian influenza virus serotype H9N2 in chickens
    • Bano S., Naeem K., Malik S.A. Evaluation of pathogenic potential of avian influenza virus serotype H9N2 in chickens. Avian Dis. 2003, 47:817-822.
    • (2003) Avian Dis. , vol.47 , pp. 817-822
    • Bano, S.1    Naeem, K.2    Malik, S.A.3
  • 4
    • 36749000488 scopus 로고    scopus 로고
    • M2 protein-a proton channel of influenza A virus
    • Betakova T. M2 protein-a proton channel of influenza A virus. Curr. Pharm. Des. 2007, 13:3231-3235.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 3231-3235
    • Betakova, T.1
  • 5
    • 0030775140 scopus 로고    scopus 로고
    • Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
    • Blachere N.E., Li Z., Chandawarkar R.Y., Suto R., Jaikaria N.S., Basu S., et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J. Exp. Med. 1997, 186:1315.
    • (1997) J. Exp. Med. , vol.186 , pp. 1315
    • Blachere, N.E.1    Li, Z.2    Chandawarkar, R.Y.3    Suto, R.4    Jaikaria, N.S.5    Basu, S.6
  • 6
    • 46049087326 scopus 로고    scopus 로고
    • Vaccination and antigenic drift in influenza
    • Boni M.F. Vaccination and antigenic drift in influenza. Vaccine 2008, 26:C8-C14.
    • (2008) Vaccine , vol.26 , pp. C8-C14
    • Boni, M.F.1
  • 7
    • 23844534838 scopus 로고    scopus 로고
    • Immunization against influenza A virus: comparison of conventional inactivated, live-attenuated and recombinant baculovirus produced purified hemagglutinin and neuraminidase vaccines in a murine model system
    • Brett I.C., Johansson B.E. Immunization against influenza A virus: comparison of conventional inactivated, live-attenuated and recombinant baculovirus produced purified hemagglutinin and neuraminidase vaccines in a murine model system. Virology 2005, 339:273-280.
    • (2005) Virology , vol.339 , pp. 273-280
    • Brett, I.C.1    Johansson, B.E.2
  • 8
    • 38049183161 scopus 로고    scopus 로고
    • Vaccination with hemagglutinin or neuraminidase DNA protects BALB/c mice against influenza virus infection in presence of maternal antibody
    • Chen J., Zhang F., Fang F., Chang H., Chen Z. Vaccination with hemagglutinin or neuraminidase DNA protects BALB/c mice against influenza virus infection in presence of maternal antibody. BMC Infect. Dis. 2007, 7:118.
    • (2007) BMC Infect. Dis. , vol.7 , pp. 118
    • Chen, J.1    Zhang, F.2    Fang, F.3    Chang, H.4    Chen, Z.5
  • 9
    • 45749148234 scopus 로고    scopus 로고
    • An inactivated vaccine to control the current H9N2 low pathogenic avian influenza in Korea
    • Choi J.G., Lee Y.J., Kim Y.J., Lee E.K., Jeong O.M., Sung H.W., et al. An inactivated vaccine to control the current H9N2 low pathogenic avian influenza in Korea. J. Vet. Sci. 2008, 9:67-74.
    • (2008) J. Vet. Sci. , vol.9 , pp. 67-74
    • Choi, J.G.1    Lee, Y.J.2    Kim, Y.J.3    Lee, E.K.4    Jeong, O.M.5    Sung, H.W.6
  • 10
    • 84861823634 scopus 로고    scopus 로고
    • In contrast to conventional inactivated influenza vaccines 4×M2e.HSP70c fusion protein fully protected mice against lethal dose of H1, H3 and H9 influenza A isolates circulating in Iran
    • Ebrahimi S.M., Dabaghian M., Tebianian M., Zabeh Jazi M.H. In contrast to conventional inactivated influenza vaccines 4×M2e.HSP70c fusion protein fully protected mice against lethal dose of H1, H3 and H9 influenza A isolates circulating in Iran. Virology 2012, 430:63-72.
    • (2012) Virology , vol.430 , pp. 63-72
    • Ebrahimi, S.M.1    Dabaghian, M.2    Tebianian, M.3    Zabeh Jazi, M.H.4
  • 11
    • 79959298626 scopus 로고    scopus 로고
    • Study of infection with an Iranian field-isolated H9N2 avian influenza virus in vaccinated and unvaccinated Japanese quail
    • Ebrahimi S.M., Ziapour S., Tebianian M., Dabaghian M., Mohammadi M. Study of infection with an Iranian field-isolated H9N2 avian influenza virus in vaccinated and unvaccinated Japanese quail. Avian Dis. 2011, 55:195-200.
    • (2011) Avian Dis. , vol.55 , pp. 195-200
    • Ebrahimi, S.M.1    Ziapour, S.2    Tebianian, M.3    Dabaghian, M.4    Mohammadi, M.5
  • 12
    • 33744523262 scopus 로고    scopus 로고
    • Protection against H1, H5, H6 and H9 influenza A infection with Liposomal matrix 2 epitope vaccines
    • Ernst W.A., Kim H.J., Tumpey T.M., Jansen A.D., Tai W., Cramer D.V., et al. Protection against H1, H5, H6 and H9 influenza A infection with Liposomal matrix 2 epitope vaccines. Vaccine 2006, 24:5158-5168.
    • (2006) Vaccine , vol.24 , pp. 5158-5168
    • Ernst, W.A.1    Kim, H.J.2    Tumpey, T.M.3    Jansen, A.D.4    Tai, W.5    Cramer, D.V.6
  • 14
    • 3843069907 scopus 로고    scopus 로고
    • Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys
    • Fan J., Liang X., Horton M.S., Perry H.C., Citron M.P., Heidecker G.J., et al. Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys. Vaccine 2004, 22:2993-3003.
    • (2004) Vaccine , vol.22 , pp. 2993-3003
    • Fan, J.1    Liang, X.2    Horton, M.S.3    Perry, H.C.4    Citron, M.P.5    Heidecker, G.J.6
  • 15
    • 36749090029 scopus 로고    scopus 로고
    • Characterization of immunity induced by M2e of influenza virus
    • Fan W., Huang J.H., Yuan X.Y., Huang W.H., Chen Y.H. Characterization of immunity induced by M2e of influenza virus. Vaccine 2007, 25:8868-8873.
    • (2007) Vaccine , vol.25 , pp. 8868-8873
    • Fan, W.1    Huang, J.H.2    Yuan, X.Y.3    Huang, W.H.4    Chen, Y.H.5
  • 17
    • 0033522471 scopus 로고    scopus 로고
    • Modified M2 proteins produce heterotypic immunity against influenza A virus
    • Frace A.M., Klimov A.I., Rowe T., Black R.A., Katz J.M. Modified M2 proteins produce heterotypic immunity against influenza A virus. Vaccine 1999, 17:2237-2244.
    • (1999) Vaccine , vol.17 , pp. 2237-2244
    • Frace, A.M.1    Klimov, A.I.2    Rowe, T.3    Black, R.A.4    Katz, J.M.5
  • 18
    • 77950831046 scopus 로고    scopus 로고
    • Cytotoxic T cells are the predominant players providing cross-protective immunity induced by gamma-irradiated influenza A viruses
    • Furuya Y., Chan J., Regner M., et al. Cytotoxic T cells are the predominant players providing cross-protective immunity induced by gamma-irradiated influenza A viruses. J. Virol. 2010, 84:4212-4221.
    • (2010) J. Virol. , vol.84 , pp. 4212-4221
    • Furuya, Y.1    Chan, J.2    Regner, M.3
  • 19
    • 37449031125 scopus 로고    scopus 로고
    • Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
    • Huleatt J.W., Valerian N., Priyanka D., Yan H., Duane H., Andrea J., et al. Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 2008, 26:201-214.
    • (2008) Vaccine , vol.26 , pp. 201-214
    • Huleatt, J.W.1    Valerian, N.2    Priyanka, D.3    Yan, H.4    Duane, H.5    Andrea, J.6
  • 20
    • 2142810269 scopus 로고    scopus 로고
    • Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
    • Jegerlehner A., Schmitz N., Storni T., Bachmann M.F. Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. J. Immunol. 2004, 172:5598-5605.
    • (2004) J. Immunol. , vol.172 , pp. 5598-5605
    • Jegerlehner, A.1    Schmitz, N.2    Storni, T.3    Bachmann, M.F.4
  • 21
    • 8744315054 scopus 로고    scopus 로고
    • Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickens
    • Kishida N., Sakoda Y., Eto M., Sunaga Y., Kida H. Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickens. Arch. Virol. 2004, 149:2095-2104.
    • (2004) Arch. Virol. , vol.149 , pp. 2095-2104
    • Kishida, N.1    Sakoda, Y.2    Eto, M.3    Sunaga, Y.4    Kida, H.5
  • 22
    • 2942541216 scopus 로고    scopus 로고
    • Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken
    • Kong X., Hu Y., Rui R., Wang D., Li X. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int. Immuno. Pharmacol. 2004, 4:975-982.
    • (2004) Int. Immuno. Pharmacol. , vol.4 , pp. 975-982
    • Kong, X.1    Hu, Y.2    Rui, R.3    Wang, D.4    Li, X.5
  • 23
    • 70350325296 scopus 로고    scopus 로고
    • Vaccination of chickens with recombinant Salmonella expressing M2e and CD154 epitopes increases protection and decreases viral shedding after low pathogenic avian influenza challenge
    • Layton S., Kapczynski D.R., Higgins S., Higgins J., wolfenden A.D., et al. Vaccination of chickens with recombinant Salmonella expressing M2e and CD154 epitopes increases protection and decreases viral shedding after low pathogenic avian influenza challenge. Poult. Sci. 2009, 88:2244-2252.
    • (2009) Poult. Sci. , vol.88 , pp. 2244-2252
    • Layton, S.1    Kapczynski, D.R.2    Higgins, S.3    Higgins, J.4    Wolfenden, A.D.5
  • 24
    • 34247638619 scopus 로고    scopus 로고
    • Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection
    • Le Gall-Reculé G., Cherbonnel M., Pelotte N., Blanchard P., Morin Y., Jestin V. Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection. Avian Dis. 2007, 51:490-494.
    • (2007) Avian Dis. , vol.51 , pp. 490-494
    • Le Gall-Reculé, G.1    Cherbonnel, M.2    Pelotte, N.3    Blanchard, P.4    Morin, Y.5    Jestin, V.6
  • 25
    • 77951883726 scopus 로고    scopus 로고
    • Viral shedding and clinical illness in naturally acquired influenza virus infections
    • Lincoln L.H.L., Benjamin J.C., Vicky J.F., Chan K.H., Eric H.Y.L., et al. Viral shedding and clinical illness in naturally acquired influenza virus infections. J. Infect. Dis. 2010, 201:1509-1516.
    • (2010) J. Infect. Dis. , vol.201 , pp. 1509-1516
    • Lincoln, L.H.L.1    Benjamin, J.C.2    Vicky, J.F.3    Chan, K.H.4    Eric, H.Y.L.5
  • 26
    • 15244346249 scopus 로고    scopus 로고
    • Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design
    • Liu W., Zou P., Ding J., Lu Y., Chen Y.H. Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design. Microbes Infect. 2005, 7:171-177.
    • (2005) Microbes Infect. , vol.7 , pp. 171-177
    • Liu, W.1    Zou, P.2    Ding, J.3    Lu, Y.4    Chen, Y.H.5
  • 27
    • 77955555710 scopus 로고    scopus 로고
    • Genetic control of immune responses to influenza A matrix 2 protein (M2)
    • Misplon J.A., Lo C.Y., Gabbard J.D., Tompkins S.M., Epstein S.L. Genetic control of immune responses to influenza A matrix 2 protein (M2). Vaccine 2010, 28:5817-5827.
    • (2010) Vaccine , vol.28 , pp. 5817-5827
    • Misplon, J.A.1    Lo, C.Y.2    Gabbard, J.D.3    Tompkins, S.M.4    Epstein, S.L.5
  • 28
    • 25444501243 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for influenza
    • Moscona A. Neuraminidase inhibitors for influenza. N. Engl. J. Med. 2005, 353:1363-1373.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1363-1373
    • Moscona, A.1
  • 29
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application of proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application of proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 0038402706 scopus 로고    scopus 로고
    • Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2
    • Mozdzanowska K., Feng J., Eid M., Kragol G., Cudic M., Gerhard W., et al. Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2. Vaccine 2003, 21:2616-2626.
    • (2003) Vaccine , vol.21 , pp. 2616-2626
    • Mozdzanowska, K.1    Feng, J.2    Eid, M.3    Kragol, G.4    Cudic, M.5    Gerhard, W.6
  • 31
    • 0033079822 scopus 로고    scopus 로고
    • Treatment of influenza virus-infected SCID mice with non-neutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection
    • Mozdzanowska K., Maiese K., Furchner M., Gerhard W. Treatment of influenza virus-infected SCID mice with non-neutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection. Virology 1999, 254:138-146.
    • (1999) Virology , vol.254 , pp. 138-146
    • Mozdzanowska, K.1    Maiese, K.2    Furchner, M.3    Gerhard, W.4
  • 32
    • 0032874490 scopus 로고    scopus 로고
    • A universal influenza A vaccine based on the extracellular domain of the M2 protein
    • Neirynck S., Deroo T., Saelens X., Vanlandschoot P., Jou W.M., Fiers W. A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat. Med. 1999, 5:1157-1163.
    • (1999) Nat. Med. , vol.5 , pp. 1157-1163
    • Neirynck, S.1    Deroo, T.2    Saelens, X.3    Vanlandschoot, P.4    Jou, W.M.5    Fiers, W.6
  • 33
    • 33646050932 scopus 로고    scopus 로고
    • Protection against avian influenza H9N2 virus challenge by immunization with hemagglutinin or neuraminidase-expressing DNA in BALB/c mice
    • Qiu M., Fang F., Chen Y., Wang H., Chen Q., Chang H., Wang F., et al. Protection against avian influenza H9N2 virus challenge by immunization with hemagglutinin or neuraminidase-expressing DNA in BALB/c mice. Biochem. Biophys. Res. Commun. 2006, 343:1124-1131.
    • (2006) Biochem. Biophys. Res. Commun. , vol.343 , pp. 1124-1131
    • Qiu, M.1    Fang, F.2    Chen, Y.3    Wang, H.4    Chen, Q.5    Chang, H.6    Wang, F.7
  • 34
    • 33745158157 scopus 로고
    • Simple method for estimating fifty per cent endpoints
    • Reed L.J., Muench H.A. Simple method for estimating fifty per cent endpoints. Am. J. Hyg. 1938, 27:493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.A.2
  • 35
    • 0037392976 scopus 로고    scopus 로고
    • Antibody response to influenza infection of mice: different patterns for glycoprotein and nucleocapsid antigens
    • Sealy R., Surman S., Hurwitz J.L., Coleclough C. Antibody response to influenza infection of mice: different patterns for glycoprotein and nucleocapsid antigens. Immunology 2003, 108:431-439.
    • (2003) Immunology , vol.108 , pp. 431-439
    • Sealy, R.1    Surman, S.2    Hurwitz, J.L.3    Coleclough, C.4
  • 36
    • 0141857721 scopus 로고    scopus 로고
    • Avian influenza in the western Hemisphere including the Pacific Islands and Australia
    • Senne D.A. Avian influenza in the western Hemisphere including the Pacific Islands and Australia. Avian Dis. 2003, 47:798-805.
    • (2003) Avian Dis. , vol.47 , pp. 798-805
    • Senne, D.A.1
  • 37
    • 0028821987 scopus 로고
    • Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein
    • Slepushkin V.A., Katz J.M., Black R.A., Gamble W.C., Rota P.A., Cox N.J. Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein. Vaccine 1995, 13:1399-1402.
    • (1995) Vaccine , vol.13 , pp. 1399-1402
    • Slepushkin, V.A.1    Katz, J.M.2    Black, R.A.3    Gamble, W.C.4    Rota, P.A.5    Cox, N.J.6
  • 38
    • 79251575047 scopus 로고    scopus 로고
    • Influenza virus-like particles containing M2 induce broadly cross protective immunity
    • Song J.M., Wang B.Z., Park K.M., Van R.N., Quan F.S., Kim M.C., et al. Influenza virus-like particles containing M2 induce broadly cross protective immunity. PLoS One 2011, 6:e14538.
    • (2011) PLoS One , vol.6 , pp. e14538
    • Song, J.M.1    Wang, B.Z.2    Park, K.M.3    Van, R.N.4    Quan, F.S.5    Kim, M.C.6
  • 39
    • 78349283472 scopus 로고    scopus 로고
    • The pathogenesis of low pathogenicity H7 avian influenza viruses in chickens, ducks and turkeys
    • Spackman E., Gelb J., Preskenis L.A., Ladman B.S., Pope C.R., Pantin-Jackwood M.J., et al. The pathogenesis of low pathogenicity H7 avian influenza viruses in chickens, ducks and turkeys. Virol. J. 2010, 7:331.
    • (2010) Virol. J. , vol.7 , pp. 331
    • Spackman, E.1    Gelb, J.2    Preskenis, L.A.3    Ladman, B.S.4    Pope, C.R.5    Pantin-Jackwood, M.J.6
  • 41
    • 33947590474 scopus 로고    scopus 로고
    • Scientific barriers to developing vaccines against avian influenza viruses
    • Subbarao K., Joseph T. Scientific barriers to developing vaccines against avian influenza viruses. Nat. Rev. Immunol. 2007, 7:267-278.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 267-278
    • Subbarao, K.1    Joseph, T.2
  • 42
    • 84857659160 scopus 로고    scopus 로고
    • Evaluation of the protective efficacy of a commercial vaccine against different antigenic groups of H9N2 influenza viruses in chickens
    • Sun Y., Pu J., Fan L., Sun H., Wang J., Zhang Y., et al. Evaluation of the protective efficacy of a commercial vaccine against different antigenic groups of H9N2 influenza viruses in chickens. Vet. Microbiol. 2012, 156:193-199.
    • (2012) Vet. Microbiol. , vol.156 , pp. 193-199
    • Sun, Y.1    Pu, J.2    Fan, L.3    Sun, H.4    Wang, J.5    Zhang, Y.6
  • 43
    • 0041625528 scopus 로고    scopus 로고
    • Influenza
    • Iowa State University Press, Ames, IA, Y.M. Saif, H.J. Barnes, J.R. Glisson, A.M. Fadly, L.R. McDougald, D.E. Swayne (Eds.)
    • Swayne D.E., Halvorson D.A. Influenza. Diseases of Poultry 2003, 132-160. Iowa State University Press, Ames, IA. Y.M. Saif, H.J. Barnes, J.R. Glisson, A.M. Fadly, L.R. McDougald, D.E. Swayne (Eds.).Diseases of Poultry. Iowa State University Press, Ames, IA, pp. 132-160.
    • (2003) Diseases of Poultry , pp. 132-160
    • Swayne, D.E.1    Halvorson, D.A.2
  • 44
    • 34547912473 scopus 로고    scopus 로고
    • Hsp-based tumor vaccines: state-of-the-art and future directions
    • Takakura Y., Takemoto S., Nishikawa M. Hsp-based tumor vaccines: state-of-the-art and future directions. Curr. Opin. Mol. Ther. 2007, 9:385-391.
    • (2007) Curr. Opin. Mol. Ther. , vol.9 , pp. 385-391
    • Takakura, Y.1    Takemoto, S.2    Nishikawa, M.3
  • 45
    • 17644391384 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice
    • Takemoto S., Nishikawa M., Takakura Y. Pharmacokinetics and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice. Pharm. Res. 2005, 22:419-426.
    • (2005) Pharm. Res. , vol.22 , pp. 419-426
    • Takemoto, S.1    Nishikawa, M.2    Takakura, Y.3
  • 46
    • 2142750909 scopus 로고    scopus 로고
    • Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages
    • Tobian A.A.R., Canaday D.H., Boom W.H., Harding C.V. Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages. J. Immunol. 2004, 172:5277.
    • (2004) J. Immunol. , vol.172 , pp. 5277
    • Tobian, A.A.R.1    Canaday, D.H.2    Boom, W.H.3    Harding, C.V.4
  • 47
    • 33847348999 scopus 로고    scopus 로고
    • Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1
    • Tompkins S.M., Zhao Z.S., Lo C.Y., Misplon J.A., Liu T., et al. Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emerg. Infect. Dis. 2007, 13:426-435.
    • (2007) Emerg. Infect. Dis. , vol.13 , pp. 426-435
    • Tompkins, S.M.1    Zhao, Z.S.2    Lo, C.Y.3    Misplon, J.A.4    Liu, T.5
  • 48
    • 0024151944 scopus 로고
    • Structure and function of human and murine receptors for IgG
    • Unkeless J.C., Scigliano E., Freedman V.H. Structure and function of human and murine receptors for IgG. Annu. Rev. Immunol. 1988, 6:251-281.
    • (1988) Annu. Rev. Immunol. , vol.6 , pp. 251-281
    • Unkeless, J.C.1    Scigliano, E.2    Freedman, V.H.3
  • 49
    • 0035858117 scopus 로고    scopus 로고
    • Live attenuated vaccines against influenza; an historical review
    • Wareing M.D., Tannock G.A. Live attenuated vaccines against influenza; an historical review. Vaccine 2001, 19:3320-3330.
    • (2001) Vaccine , vol.19 , pp. 3320-3330
    • Wareing, M.D.1    Tannock, G.A.2
  • 50
    • 36749090029 scopus 로고    scopus 로고
    • Characterization of immunity induced by M2e of influenza virus
    • Wu F., Huang J.H., Yuan X.Y., Huang W.S., Chen Y.H. Characterization of immunity induced by M2e of influenza virus. Vaccine 2007, 25:8868-8873.
    • (2007) Vaccine , vol.25 , pp. 8868-8873
    • Wu, F.1    Huang, J.H.2    Yuan, X.Y.3    Huang, W.S.4    Chen, Y.H.5
  • 51
    • 67649479249 scopus 로고    scopus 로고
    • The co-administration of CpG-ODN influenced protective activity of influenza M2e vaccine
    • Wu F., Yuan X.Y., Li J., Chen Y.H. The co-administration of CpG-ODN influenced protective activity of influenza M2e vaccine. Vaccine 2009, 27:4320-4324.
    • (2009) Vaccine , vol.27 , pp. 4320-4324
    • Wu, F.1    Yuan, X.Y.2    Li, J.3    Chen, Y.H.4
  • 52
    • 84863863794 scopus 로고    scopus 로고
    • In vivo electroporation enhances immunogenicity and protection against influenza A virus challenge of an M2e-HSP70c DNA vaccine
    • Zabeh Jazi M.H., Dabaghian M., Tebianian M., Gharagozlou M.H., Ebrahimi S.M. In vivo electroporation enhances immunogenicity and protection against influenza A virus challenge of an M2e-HSP70c DNA vaccine. Virus Res. 2012, 167:219-225.
    • (2012) Virus Res. , vol.167 , pp. 219-225
    • Zabeh Jazi, M.H.1    Dabaghian, M.2    Tebianian, M.3    Gharagozlou, M.H.4    Ebrahimi, S.M.5
  • 53
    • 77957821697 scopus 로고    scopus 로고
    • Induction of the protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant
    • Zhao G., Du L., Xiao W., Sun S., Lin Y., Chen M., et al. Induction of the protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant. Vaccine 2010, 28:7233-7240.
    • (2010) Vaccine , vol.28 , pp. 7233-7240
    • Zhao, G.1    Du, L.2    Xiao, W.3    Sun, S.4    Lin, Y.5    Chen, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.