Lipoprotein(a) mass: A massively misunderstood metric

Journal of Clinical Lipidology

Volumn 8, Issue 6, 2014, Pages 550-553

  McConnell, Joseph P ^a   Guadagno, Philip A ^a   Dayspring, Thomas D ^b   Hoefner, Daniel M ^a   Thiselton, Dawn L ^a   Warnick, G Russell ^a   Harris, William S ^a  

^a Health Diagnostic Laboratory Inc   (United States)

^b Foundation for Health Information Technology   (United States)

Author keywords

Apolipoprotein(a); Laboratory methods; Lipoprotein(a); Lipoproteins; Particle number

Indexed keywords

CARBOHYDRATE; LIPID; LIPOPROTEIN A; PROTEIN; BIOLOGICAL MARKER; ISOPROTEIN;

CHEMICAL COMPOSITION; CLINICAL LABORATORY; DIAGNOSTIC PROCEDURE; HUMAN; MOLECULAR WEIGHT; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; RISK FACTOR; ANIMAL; BLOOD; CARDIOVASCULAR DISEASES; CHEMISTRY; METRIC SYSTEM; MOLECULAR DIAGNOSIS; PROGNOSIS; RISK; STANDARD; STANDARDS;

ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; HUMANS; LIPIDS; LIPOPROTEIN(A); METRIC SYSTEM; MOLECULAR DIAGNOSTIC TECHNIQUES; PROGNOSIS; PROTEIN ISOFORMS; REFERENCE STANDARDS; RISK;

EID: 84909598302     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2014.08.003     Document Type: Review

References (26)

1. J.J. Albers, A. Slee, K.D. O'Brien, and et al. Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: The AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglyceride and Impact on Global Health Outcomes) J Am Coll Cardiol 62 17 2013 1575 1579
2. T.A. Jacobson Lipoprotein(a), cardiovascular disease, and contemporary management Mayo Clin Proc 88 11 2013 1294 1311
3. C. Lackner, J.C. Cohen, and H.H. Hobbs Molecular definition of the extreme size polymorphism in apolipoprotein(a) Hum Mol Genet 2 7 1993 933 940
4. G. Utermann The mysteries of lipoprotein(a) [Review] Science 246 1989 904 910
5. J.J. Albers, and W.R. Hazzard Immunochemical quantification of human plasma Lp(a) lipoprotein Lipids 9 1 1974 15 26
6. G.M. Kostner, P. Avogaro, G. Cazzolato, E. Marth, G. Bittolo-Bon, and G.B. Qunici Lipoprotein Lp(a) and the risk for myocardial infarction Atherosclerosis 38 1-2 1981 51 61
7. J.J. Albers, S.M. Marcovina, and M.S. Lodge The unique lipoprotein(a): properties and immunochemical measurement Clin Chem 36 12 1990 2019 2026
8. K. Nakajima, J. Hinman, D. Pfaffinger, C. Edelstein, and A.M. Scanu Changes in plasma triglyceride levels shift lipoprotein(a) density in parallel with that of LDL independently of apolipoprotein(a) size Arterioscler Thromb Vasc Biol 21 7 2001 1238 1243
9. J. Rubin, F. Paultre, C.H. Tuck, and et al. Apolipoprotein [a] genotype influences isoform dominance pattern differently in African Americans and Caucasians J Lipid Res 43 2 2002 234 244
10. L.M. Baudhuin, S.J. Hartman, J.F. O'Brien, and et al. Electrophoretic measurement of lipoprotein(a) cholesterol in plasma with and without ultracentrifugation: comparison with an immunoturbidimetric lipoprotein(a) method Clin Biochem 37 6 2004 481 488
11. L.J. Seman, C. DeLuca, J.L. Jenner, and et al. Lipoprotein(a)-cholesterol and coronary heart disease in the Framingham Heart Study Clin Chem 45 7 1999 1039 1046
12. S.M. Marcovina, and M.L. Koschinsky Lipoprotein(a): Structure, Measurement, and Clinical Significance Edtion ed N. Rifai, G.R. Warnick, M.H. Dominiczak, Handbook of Lipoprotein Testing 2000 AACC Press Washington, DC 345 385
13. P.A. Guadagno, E. Summers, B. Stanovick, and et al. Validation of Lp(a) particle number analysis by quantitative Lipo-IFE J Clin Lipidol 7 3 2013 240 241
14. L.J. Seman, J.L. Jenner, J.R. McNamara, and E.J. Schaefer Quantification of lipoprotein(a) in plasma by assaying cholesterol in lectin-bound plasma fraction Clin Chem 40 3 1994 400 403
15. W.V. Brown, C.M. Ballantyne, P.H. Jones, and S. Marcovina Management of Lp(a) J Clin Lipidol 4 4 2010 240 247
16. C.Y. Yang, F.S. Lee, L. Chan, D.A. Sparrow, J.T. Sparrow, and A.M. Gotto Jr. Determination of the molecular mass of apolipoprotein B-100. A chemical approach Biochem J 239 3 1986 777 780
17. B.W. Shen, A.M. Scanu, and F.J. Kezdy Structure of human serum lipoproteins inferred from compositional analysis Proc Natl Acad Sci U S A 74 3 1977 837 841
18. S.M. Marcovina, J.J. Albers, B. Gabel, M.L. Koschinsky, and V.P. Gaur Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a) Clin Chem 41 2 1995 246 255
19. R.D. Ellefson, B.J. Jimenez, and R.C. Smith Pre-beta (or alpha 2) lipoprotein of high density in human blood Mayo Clin Proc 46 5 1971 328 332
20. E.J. Jeyarajah, W.C. Cromwell, and J.D. Otvos Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy Clin Lab Med 26 2006 847 870
21. W.C. Cromwell, J.D. Otvos, M.J. Keyes, and et al. LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management J Clin Lipidol 1 6 2007 583 592
22. S. Mora, R.J. Glynn, and P.M. Ridker High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy Circulation 128 11 2013 1189 1197
23. D.J. Rader, W. Cain, K. Ikewaki, and et al. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate J Clin Invest 93 6 1994 2758 2763
24. H. Dieplinger, and G. Utermann The seventh myth of lipoprotein(a): where and how is it assembled? Curr Opin Lipidol 10 3 1999 275 283
25. R. Clarke, J.F. Peden, J.C. Hopewell, and et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease N Engl J Med 361 26 2009 2518 2528
26. S. Erqou, A. Thompson, E. Di Angelantonio, and et al. Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants J Am Coll Cardiol 55 19 2010 2160 2167