Effect of lung squamous cell carcinoma tumor microenvironment on the CD105+ endothelial cell proteome

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 4717-4729

  Zhuo, Huiqin ^a   Lyu, Zhi ^a   Su, Jing ^b   He, Jian ^b   Pei, Yihua ^a   Cheng, Xiao ^a   Zhou, Nuo ^b   Lu, Xiaoling ^b   Zhou, Sufang ^b   Zhao, Yongxiang ^b  

^a ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

iTRAQ; lung squamous cell carcinoma; paratumor endothelial cells; proteomics; tumor endothelial cells

Indexed keywords

CELL ADHESION MOLECULE; ENDOGLIN; NEUROPILIN 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PROTEOME;

ANGIOGENESIS; ANTIANGIOGENIC THERAPY; APOPTOSIS; ARTICLE; CELL MIGRATION; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE ONTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ION EXCHANGE CHROMATOGRAPHY; LUNG SQUAMOUS CELL CARCINOMA; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TUMOR MICROENVIRONMENT; UPREGULATION; BIOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LUNG TUMOR; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TANDEM MASS SPECTROMETRY;

ANTIGENS, CD; CARCINOMA, SQUAMOUS CELL; CHROMATOGRAPHY, ION EXCHANGE; CHROMATOGRAPHY, LIQUID; COMPUTATIONAL BIOLOGY; ENDOTHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; LUNG NEOPLASMS; PROTEOME; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TUMOR MICROENVIRONMENT;

EID: 84908889441     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5006229     Document Type: Article

References (40)

1. Chen, H. X.; Gore-Langton, R. E.; Cheson, B. D. Clinical trials referral resource: Current clinical trials of the anti-VEGF monoclonal antibody bevacizumab Oncology 2001, 15 (8) 1017, 1020-1023-1026
2. Shinkaruk, S.; Bayle, M.; Lain, G.; Deleris, G. Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy Curr. Med. Chem. Anticancer Agents 2003, 3 (2) 95-117
3. Santel, A.; Aleku, M.; Keil, O.; Endruschat, J.; Esche, V.; Durieux, B.; Loffler, K.; Fechtner, M.; Rohl, T.; Fisch, G.; Dames, S.; Arnold, W.; Giese, K.; Kippel, A.; Kaufmann, J. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy Gene Ther. 2006, 13 (18) 1360-1370
4. Liang, W.; Kujawski, M.; Wu, J.; Lu, J.; Herrmann, A.; Loera, S.; Yen, Y.; Lee, F.; Yu, H.; Wen, W.; Jove, R. Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment Clin. Cancer Res. 2010, 16 (3) 924-935
5. Lu, C.; Kamat, A. A.; Lin, Y. G.; Merritt, W. M.; Lander, C. N.; Kim, T. J.; Spannuth, W.; Arumugam, T.; Han, L. Y.; Jennings, N. B.; Logsdon, C.; Jaffe, R. B.; Coleman, R. L.; Sood, A. K. Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma Clin. Cancer Res. 2007, 13 (14) 4209-4217
6. St Croix, B.; Rago, C.; Velculescu, V.; Traverso, G.; Romans, K. E.; Montgomery, E.; Lal, A.; Riggins, G. J.; Lengauer, C.; Vogelstein, B.; Kinzler, K. W. Genes expressed in human tumor endothelium Science 2000, 289 (5482) 1197-1202
7. Xiong, Y. Q.; Sun, H. C.; Zhang, W.; Zhu, X. D.; Zhuang, P. Y.; Zhang, J. B.; Wang, L.; Wu, W. Z.; Qin, L. X.; Tang, Z. Y. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells Clin. Cancer Res. 2009, 15 (15) 4838-4846
8. Ria, R.; Todoerti, K.; Berardi, S.; Coluccia, A. M.; De Luisi, A.; Mattioli, M.; Ronchetti, D.; Morabito, F.; Guarini, A.; Petrucci, M. T.; Dammacco, F.; Ribatti, D.; Neri, A.; Vacca, A. Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma Clin. Cancer Res. 2009, 15 (17) 5369-5378
9. Ruoslahti, E.; Rajotte, D. An address system in the vasculature of normal tissues and tumors Annu. Rev. Immunol. 2000, 18, 813-827
10. Matsuda, K.; Ohga, N.; Hida, Y.; Muraki, C.; Tsuchiya, K.; Kurosu, T.; Akino, T.; Shih, S. C.; Totsuka, Y.; Klagsbrun, M.; Shindoh, M.; Hida, K. Isolated tumor endothelial cells maintain specific character during long-term culture Biochem. Biophys. Res. Commun. 2010, 394 (4) 947-954
11. Hu, H.; Ran, Y.; Zhang, Y.; Zhou, Z.; Harris, S. J.; Yu, L.; Sun, L.; Pan, J.; Liu, J.; Yang, Z. Antibody library-based tumor endothelial cells surface proteomic functional screen reveals migration-stimulating factor as an anti-angiogenic target Mol. Cell. Proteomics 2009, 8 (4) 816-826
12. Mathias, R. A.; Gopal, S. K.; Simpson, R. J. Contribution of cells undergoing epithelial-mesenchymal transition to the tumour microenvironment J. Proteomics 2013, 78, 545-557
13. Fonsatti, E.; Nicolay, H. J.; Altomonte, M.; Covre, A.; Maio, M. Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumors Cardiovasc. Res. 2010, 86 (1) 12-19
14. Durr, E.; Yu, J.; Krasinska, K. M.; Carver, L. A.; Yates, J. R.; Testa, J. E.; Oh, P.; Schnitzer, J. E. Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and cell culture Nat. Biotechnol. 2004, 22 (8) 985-992
15. Park, H. J.; Kim, B. G.; Lee, S. J.; Heo, S. H.; Kim, J. Y.; Kwon, T. H.; Lee, E. B.; Ryoo, H. M.; Cho, J. Y. Proteomic profiling of endothelial cells in human lung cancer J. Proteome Res. 2008, 7 (3) 1138-1150
16. Zhuo, H. Q.; Peng, Y.; Yao, Q.; Zhou, N.; Zhou, S. F.; He, J.; Fang, Y.; Li, X.; Jin, H. W.; Lu, X. L.; Zhao, Y. X. Tumor imaging and interferon-γ-inducible protein-10 gene transfer using a highly efficient transferrin-conjugated liposome system in mice Clin. Cancer Res. 2013, 19 (15) 4206-4217
17. Zhang, P. F.; Zeng, G. Q.; Hu, R.; Li, C.; Yi, H.; Li, M. Y.; Li, X. H.; Qu, J. Q.; Wan, X. X.; He, Q. Y.; Li, J. H.; Chen, Y.; Ye, X.; Li, J. Y.; Wang, Y. Y.; Feng, X. P.; Xiao, Z. Q. Identification of flotillin-1 as a novel biomarker for lymph node 3 metastasis and prognosis of lung adenocarcinoma by 4 quantitative plasma membrane proteome analysis J. Proteomics 2012, 77, 202-214
18. Ghosh, D.; Li, Z.; Tan, X. F.; Lim, T. K.; Mao, Y.; Lin, Q. iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis Mol. Cell. Proteomics 2013, 12 (7) 1865-1880
19. Ahn, J. M.; Sung, H. J.; Yoon, Y. H.; Kim, B. G.; Yang, W. S.; Lee, C.; Park, H. M.; Kim, B. J.; Kim, B. G.; Lee, S. Y.; An, H. J.; Cho, J. Y. Integrated glycoproteomics demonstrates fucosylated serum paraoxonase 1 alterations in small cell lung cancer Mol. Cell. Proteomics 2014, 13 (1) 30-48
20. Mundt, F.; Johansson, H.; Forshed, J.; Arslan, S.; Metintas, M.; Dobra, K.; Lehtio, J.; Hjerpe, A. Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesothelioma Mol. Cell Proteomics 2014, 13 (3) 701-715
21. Zhuo, H. Q.; Huang, L.; Huang, H. Q.; Cai, Z. W. Effects of chronic tramadol exposure on the zebrafish brain: A proteomic study J. Proteomics 2012, 75 (11) 3351-3364
22. Bussolati, B.; Deambrosis, I.; Russo, S.; Deregibus, M. C.; Camussi, G. Altered angiogenesis and survival in human tumor-derived endothelial cells FASEB J. 2003, 17 (9) 1159-1161
23. Hida, K.; Klagsbrun, M. A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities Cancer Res. 2005, 65 (7) 2507-2510
24. Kwon, M. S.; Park, C. S.; Choi, K.; Ahnn, J.; Kim, J. I.; Eom, S. H.; Kaufman, S. J.; Song, W. K. Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling Mol. Biol. Cell 2000, 11 (4) 1433-1443
25. Wessells, H.; Sullivan, C. J.; Tsubota, Y.; Engel, K. L.; Kim, B.; Olson, N. E.; Thorner, D.; Chitaley, K. Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function Physiol. Genomics 2009, 39 (2) 100-108
26. Fukushima, K.; Miyamoto, S.; Tsukimori, K.; Kobayashi, H.; Seki, H.; Takeda, S.; Kensuke, E.; Ohtani, K.; Shibuya, M.; Nakano, H. Tumor necrosis factor and vascular endothelial growth factor induce endothelial integrin repertories, regulating endovascular differentiation and apoptosis in a human extravillous trophoblast cell line Biol. Reprod. 2005, 73 (1) 172-179
27. Carison, T. R.; Hu, H.; Braren, R.; Kim, Y. H.; Wang, R. A. Cell-autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice Development 2008, 135 (12) 2193-2202
28. Hood, J. D.; Cheresh, D. A. Role of integrins in cell invasion and migration Nat. Rev. Cancer 2002, 2 (2) 91-100
29. Bouvard, D.; Pouwels, J.; De Franceschi, N.; Ivaska, J. Integrin inactivators: balancing cellular functions in vitro and in vivo Nat. Rev. Mol. Cell. Biol. 2013, 14 (7) 430-442
30. Chouaib, S.; Kieda, C.; Benlalam, H.; Noman, M. Z.; Mami-Chouaib, F.; Rüegg, C. Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells Crit. Rev. Immunol. 2010, 30 (6) 529-545
31. Jeon, S. M.; Chandel, N. S.; Hay, N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 2012, 485 (7400) 661-665
32. Hida, K.; Akiyama, K.; Ohga, N.; Maishi, N.; Hida, Y. Tumour endothelial cells acquire drug resistance in a tumour microenvironment J. Biochem. 2013, 153 (3) 243-249
33. Gerthoffer, W. T. Mechanisms of vascular smooth muscle cell migration Circ. Res. 2007, 100 (5) 607-621
34. Kamykowski, J.; Carlton, P.; Sehgal, S.; Storrie, B. Quantitative immunofluorescence mapping reveals little functional co-clustering of proteins within platelet {alpha}-granules Blood 2011, 118 (5) 1370-1373
35. Vuoriluoto, K.; Haugen, H.; Kiviluoto, S.; Mpindi, J. P.; Nevo, J.; Gjerdrum, C.; Tiron, C.; Lorens, J. B.; Ivaska, J. Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer Oncogene 2011, 30 (12) 1436-1448
36. Zeng, X.; Yang, P.; Chen, B.; Jin, X.; Liu, Y.; Zhao, X.; Liang, S. Quantitative secretome analysis reveals the interactions between epithelia and tumor cells by in vitro modulating colon cancer microenvironment J. Proteomics 2013, 89, 51-70
37. Ball, S. G.; Bayley, C.; Shuttleworth, C. A.; Kielty, C. M. Neuropilin-1 regulates platelet-derived growth factor receptor signaling in mesenchymal stem cells Biochem. J. 2010, 427 (1) 29-40
38. Chaudhary, B.; Khaled, Y. S.; Ammori, B. J.; Elkord, E. Neuropilin 1: function and therapeutic potential in cancer Cancer Immunol. Immunother. 2014, 63 (2) 81-99
39. Casazza, A.; Laoui, D.; Wenes, M.; Rizzolio, S.; Bassani, N.; Mambretti, M.; Deschoemaeker, S.; Van Ginderachter, J. A.; Tamagnone, L.; Mazzone, M. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity Cancer Cell 2013, 24 (6) 695-709
40. Steller, E. J.; Raats, D. A.; Koster, J.; Rutten, B.; Govaert, K. M.; Emmink, B. L.; Snoeren, N.; van Hooff, S. R.; Holstege, F. C.; Maas, C.; Borel Rinkes, I. H.; Kranenburg, O. PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells Neoplasia 2013, 15 (2) 204-217