Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling

Cancer Letters

Volumn 353, Issue 2, 2014, Pages 194-200

  Kim, Jun Kyum ^a   Jin, Xiong ^a   Sohn, Young Woo ^a   Jin, Xun ^a   Jeon, Hee Young ^a   Kim, Eun Jung ^a   Ham, Seok Won ^a   Jeon, Hye Min ^a   Chang, So Young ^a   Oh, Se Yeong ^a   Yin, Jinlong ^b   Kim, Sung Hak ^a,c   Park, Jong Bae ^b   Nakano, Ichiro ^c,d   Kim, Hyunggee ^a  

^a Korea University   (South Korea)

^b Hematologic Oncology Clinic   (South Korea)

^c OHIO STATE UNIVERSITY   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Astrocyte; Glioblastoma; RANKL signaling; Tumor invasive microenvironment

Indexed keywords

CYTOKINE; FIBROBLAST GROWTH FACTOR; MESSENGER RNA; ONCOSTATIN M; OSTEOCLAST DIFFERENTIATION FACTOR; SCATTER FACTOR; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TNFSF11 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INVASION; CONTROLLED STUDY; CYTOKINE RELEASE; GLIOBLASTOMA; GLIOMA; GLIOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BRAIN TUMOR; CANCER TRANSPLANTATION; CELL MOTION; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; RANKL SIGNALING; TUMOR CELL LINE; TUMOR-INVASIVE MICROENVIRONMENT;

ASTROCYTE; GLIOBLASTOMA; RANKL SIGNALING; TUMOR-INVASIVE MICROENVIRONMENT;

ANIMALS; ASTROCYTES; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CYTOKINES; GLIOBLASTOMA; HUMANS; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NF-KAPPA B; RANK LIGAND; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 84908668451     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.07.034     Document Type: Article

References (23)

1. Wen P.Y., Kesari S. Malignant gliomas in adults. N. Engl. J. Med 2008, 359:492-507.
2. Giese A., Bjerkvig R., Berens M.E., Westphal M. Cost of migration: invasion of malignant gliomas and implications for treatment. J. Clin. Oncol 2003, 21:1624-1636.
3. Jin X., Jeon H.Y., Joo K.M., Kim J.K., Jin J., Kim S.H., et al. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res 2011, 71:3066-3075.
4. Loser K., Mehling A., Loeser S., Apelt J., Kuhn A., Grabbe S., et al. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat. Med 2006, 12:1372-1379.
5. Hanada R., Hanada T., Sigl V., Schramek D., Penninger J.M. RANKL/RANK-beyond bones. J. Mol. Med. (Berl) 2011, 89:647-656.
6. Hsu H., Lacey D.L., Dunstan C.R., Solovyev I., Colombero A., Timms E., et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl Acad. Sci. U.S.A. 1999, 96:3540-3545.
7. Hanada R., Leibbrandt A., Hanada T., Kitaoka S., Furuyashiki T., Fujihara H., et al. Central control of fever and female body temperature by RANKL/RANK. Nature 2009, 462:505-509.
8. Jones D.H., Nakashima T., Sanchez O.H., Kozieradzki I., Komarova S.V., Sarosi I., et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature 2006, 440:692-696.
9. Hoelzinger D.B., Demuth T., Berens M.E. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J. Natl. Cancer Inst 2007, 99:1583-1593.
10. Morga E., Mouad-Amazzal L., Felten P., Heurtaux T., Moro M., Michelucci A., et al. Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways. Glia 2009, 57:1741-1753.
11. Lin S.T., Wang Y., Xue Y., Feng D.C., Xu Y., Xu L.Y. Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF-kappaB signaling pathway. Mol. Cell. Biochem 2008, 315:41-49.
12. Aeschlimann D., Evans B.A. The vital osteoclast: how is it regulated?. Cell Death Differ 2004, 11:S5-S7.
13. Nagayasu T., Miyata S., Hayashi N., Takano R., Kariya Y., Kamei K. Heparin structures in FGF-2-dependent morphological transformation of astrocytes. J. Biomed. Mater. Res. A 2005, 74:374-380.
14. Ridet J.L., Malhotra S.K., Privat A., Gage F.H. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 1997, 20:570-577.
15. Grosche J., Matyash V., Moller T., Verkhratsky A., Reichenbach A., Kettenmann H. Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat. Neurosci 1999, 2:139-143.
16. Sofroniew M.V. Reactive astrocytes in neural repair and protection. Neuroscientist 2005, 11:400-407.
17. Lin Q., Balasubramanian K., Fan D., Kim S.J., Guo L., Wang H., et al. Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia 2010, 12:748-754.
18. Fitzgerald D.P., Palmieri D., Hua E., Hargrave E., Herring J.M., Qian Y., et al. Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization. Clin. Exp. Metastasis 2008, 25:799-810.
19. Seike T., Fujita K., Yamakawa Y., Kido M.A., Takiguchi S., Teramoto N., et al. Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin. Exp. Metastasis 2011, 28:13-25.
20. Seoane J. Escaping from the TGFbeta anti-proliferative control. Carcinogenesis 2006, 27:2148-2156.
21. Sasaki A., Naganuma H., Satoh E., Nagasaka M., Isoe S., Nakano S., et al. Secretion of transforming growth factor-beta 1 and -beta 2 by malignant glioma cells. Neurol. Med. Chir. (Tokyo) 1995, 35:423-430.
22. Nakano A., Tani E., Miyazaki K., Yamamoto Y., Furuyama J. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. J. Neurosurg 1995, 83:298-307.
23. Wick W., Platten M., Weller M. Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J. Neurooncol 2001, 53:177-185.