Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: A randomized clinical study

Medical Science Monitor

Volumn 20, Issue , 2014, Pages 2183-2188

  Skarlovnik, Ajda ^a   Janić, Miodrag ^a   Lunder, Mojca ^a   Turk, Martina ^a   Šabovič, Mišo ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Hydroxymethylglutaryl CoA reductases; Myalgia; NAD dependent; Ubiquinone

Indexed keywords

ATORVASTATIN; FLUINDOSTATIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PLACEBO; ROSUVASTATIN; SIMVASTATIN; UBIDECARENONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; UBIQUINONE;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD ANALYSIS; BRIEF PAIN INVENTORY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DAILY LIFE ACTIVITY; DOUBLE BLIND PROCEDURE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; MALE; MUSCLE FATIGUE; MUSCLE WEAKNESS; MYALGIA; PAIN INTERFERENCE SCORE; PAIN SEVERITY SCORE; POWER ANALYSIS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TRIACYLGLYCEROL BLOOD LEVEL; ANALOGS AND DERIVATIVES; BLOOD; CHEMICALLY INDUCED; DIET SUPPLEMENTATION; MIDDLE AGED; MUSCLE; PAIN MEASUREMENT; PATHOLOGY;

ACTIVITIES OF DAILY LIVING; ADULT; AGED; DIETARY SUPPLEMENTS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MUSCLES; MYALGIA; PAIN MEASUREMENT; PLACEBOS; UBIQUINONE;

EID: 84908667304     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.890777     Document Type: Article

References (14)

1. Naci, H, Brugts, JJ, Fleurence, R et al: Comparative benefts of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials. Eur J Prev Cardiol, 2013; 20(4): 641–57
2. Taylor, F, Hufman, MD, Macedo, AF et al: Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev, 2013; 1: CD00481
3. Bruckert, E, Hayem, G, Dejager, S et al: Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients – the PRIMO study. Cardiovasc Drugs Ther, 2005; 19(6): 403–14
4. Jackevicius, CA, Mamdani, M, Tu, JV: Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA, 2002; 288; 462–67
5. Pasternak, RC, Smith, SC Jr, Bairey-Merz, CN et al: ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins. Stroke, 2002; 33: 2337–41
6. Young, JM, Florkowski, CM, Molyneux, SL et al: Efect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Am J Cardiol, 2007; 100: 1400–3
7. Harper, CR, Jacobson, TA: The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr Opin Lipidol, 2007; 18: 401–8
8. Wyman, M, Leonard, M, Morledge, T: Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleve Clin J Med, 2010; 77: 435–42
9. Marcof, L, Thompson, PD: The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol, 2007; 49: 2231–37
10. Potgieter, M, Pretorius, E, Pepper, MS: Primary and secondary coenzyme Q10 defciency: the role of therapeutic supplementation. Nutr Rev, 2013; 71: 180–88
11. Caso, G, Kelly, P, McNurlan, MA, Lawson, WE: Efect of coenzyme q10 on myo-pathic symptoms in patients treated with statins. Am J Cardiol, 2007; 99: 1409–12
12. Bookstaver, DA, Burkhalter, NA, Hatzigeorgiou, C: Efect of coenzyme Q10 supplementation on statin-induced myalgias. Am J Cardiol, 2012; 110: 526–29
13. Fedacko, J, Pella, D, Fedackova, P et al: Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol, 2013; 91: 165–70
14. Mancini, GB, Tashakkor, AY, Baker, S et al: Diagnosis, prevention, and management of statin adverse efects and intolerance: Canadian Working Group Consensus update. Can J Cardiol, 2013; 29: 1553–68