Synthesis and pharmacological evaluation of 5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine derivatives as platelet aggregation inhibitors

Journal of Saudi Chemical Society

Volumn 18, Issue 5, 2014, Pages 513-519

  Challa, Nageswar Rao ^a,b   Mamidisetty, Balaji ^a   Ghanta, Mahesh Reddy ^c   Padi, Pratap Reddy ^c  

^a Srini Pharmaceuticals Ltd   (India)

^b OSMANIA UNIVERSITY   (India)

^c Macleod's Pharmaceuticals Ltd   (India)

Author keywords

Antithrombotic activity; Bioisostere; In vitro; In vivo; Platelet aggregation; Tetrazole

Indexed keywords

EID: 84908617222     PISSN: 13196103     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jscs.2011.10.016     Document Type: Article

References (18)

1. Anderson D.W., Campbell M.M., Malik M. Tetrahedron Lett. 1990, 31:1755.
2. Bernstein P.R., Vacek E.P. Synthesis 1987, 1133.
3. Born G.V.R. Nature (London) 1962, 194:927-929.
4. Christophe B., Holger B., Heiner S., Elisabeth D.C. J. Med. Chem. 2004, 47:5972-5983.
5. Christophersen, P., Dahl, B.H., 2000. WO Patent 0024707.
6. Dickstein K., Timmermans P.B.M.W.M., Segal R. Expert Opin. Investig. Drugs 1998, 7:1897.
7. Esanu, Andre, 1987. US Patent 4681888.
8. Green B.G., Toney J.H., Kozarich J.W., Grant S.K. Arch. Biochem. Biophys. 2000, 375:355.
9. Hiruyoki, K., Fumitoshi, A., Atsuhiro, S., Tomio, K., Teruhiko, I., Shigeyoshi, N., Yasunori, T., 1994. US Patent 5288726.
10. Katano K., Shitara E., Shimizu M., Sasai K., Miura T., Isomura Y., Kawagochi M., Ohuchi S., Tsuruoka T. Bioorg. Med. Chem. Lett. 1996, 6(21):2601-2606.
11. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Adv. Drug. Del. Rev. 2001, 46:3-26.
12. Nageswar R.C., Mahesh R.G., Pratap R.P. Lett. Org. Chem. 2011, 8(6):412-415.
13. Singh H., Chawla A., Kapoor V., Paul D., Malkorta R. Prog. Med. Chem. 1980, 17:151.
14. Smith R.D., Sweet C.S., Goldberg A., Timmermans P.B.M.W.M. Drugs Today 1996, 32:1.
15. Smith R.G., Cheng K., Schoen W.R., Pong S.S., Hickey G., Jacks T., Butler B., Chan W.W.S., Chaung L.Y.P., Judith F., Taylor J., Wyvratt M.J., Fisher M.H. Science 1993, 260:1640.
16. Srivastava B.K., Solanki M., Mishra B., Soni R., Jayadav S., Valani D., Jain M., Patel P.R. Bioorg. Med. Chem. Lett. 2007, 17(7):1924-1929.
17. Toney J.H., Fitzgerald P.M.D., Grover-Sharma N., Olson S.H., May W.J., Sundelof J.G., Vanderwall D.E., Cleary K.A., Grant S.K., Wu J.K., Kozarich J.W., Pompliano D.L., Hammond G.G. Chem. Biol. 1998, 5:185.
18. Toney J.H., Cleary K.A., Hammond G.G., Yuan X., May W.J., Hutchins S.M., Ashton W.T., Vanderwall D.E. Bioorg. Med. Chem. Lett. 1999, 9:2741.