Vitamin B12 deficiency

BMJ (Online)

Volumn 349, Issue , 2014, Pages

  Hunt, Alesia ^a   Harrington, Dominic ^a   Robinson, Susan ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CHLORPHENIRAMINE; COBAMAMIDE; CYANOCOBALAMIN; FERROUS SULFATE; FOLIC ACID; HAPTOCORRIN; HOMOCYSTEINE; HYDROCORTISONE; HYDROXOCOBALAMIN; INTRINSIC FACTOR; MECOBALAMIN; METHIONINE; METHYLMALONIC ACID; SUCCINYL COENZYME A; TRANSCOBALAMIN II; TRANSCOBALAMIN; VITAMIN B COMPLEX;

AGE DISTRIBUTION; ANAPHYLAXIS; CELL METABOLISM; CHILL; CLINICAL FEATURE; CYANOCOBALAMIN DEFICIENCY; DIZZINESS; DNA METABOLISM; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; FEVER; FOLIC ACID DEFICIENCY; FOOD INTAKE; HOT FLUSH; HUMAN; METHYLATION; NAUSEA; PATHOPHYSIOLOGY; PERNICIOUS ANEMIA; PREVALENCE; PRURITUS; RASH; REVIEW; BLOOD; METABOLISM; VITAMIN B 12 DEFICIENCY;

HOMOCYSTEINE; HUMANS; HYDROXOCOBALAMIN; METHYLMALONIC ACID; TRANSCOBALAMINS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; VITAMIN B COMPLEX;

EID: 84908611242     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.g5226     Document Type: Review

References (31)

1. Green R. Physiology, dietary sources, and requirements. In: Encyclopedia of human nutrition. Vol 4. Academic Press, 2013: 351-6.
2. 12 status: application in a mixed patient population. Clin Biochem 2014;47:82-6.
3. 12 deficiency. N Engl J Med 2013;368:149-60.
4. Devalia V, Hamilton M, Molloy A. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol 2014;166:496-513.
5. Harmening D. Megaloblastic anemia. In: Clinical haematology and fundamentals of haemostasis. 4th ed. F A Davis, 2002: 112-9.
6. Provan D, Singer C, Baglin T, Dokal I. Red cell disorders. In: Oxford handbook of clinical haematology. 3rd ed. Oxford University Press, 2010: 46-7.
7. Kaushansky K, Lichtman M, Beutler E, Kipp T, Seligshon U, Prchal J. Folate, cobalamin and megaloblastic anaemia. In: Williams haematology. 8th ed. McGraw Hill, 2010: 538-45.
8. 12) deficiency - investigation and management. Guidelines and protocols. 1 May 2013.
9. 12 underestimated neurological significance. Nutrients 2013;5:5031-45.
10. Allen L. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89(suppl):S693-6.
11. Pawlak R, Parrott S, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B12 deficiency among vegetarians? Nutr Rev 2013;71:110-7.
12. Gauchan D, Joshi N, Singh Gill A, Patel V, DeBari V, Guron G, et al. Does an elevated serum vitamin B(12) level mask actual vitamin B(12) deficiency in myeloproliferative disorders? Clin Lymphoma Myeloma Leuk 2012;12:269-73.
13. Quadros E. Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol 2010;148:195-204.
14. Lindenbaum J, Healton E, Savage D. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anaemia or macrocytosis. N Engl J Med 1988;318:1720-8.
15. 12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev 2007;21:113-30.
16. 12, holotranscobalamin. Clin Chem 2007;53:963-70.
17. 12 status in the elderly. Clin Chem 2011;57:856-63.
18. Sobczyńska-Malefora A, Harrington D, Voong K, Shearer M. Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B12 had been excluded. Adv Hematol 2014;465623.
19. 12 and pernicious anemia - the dawn of molecular medicine. N Engl J Med 370;8:773-6.
20. Vogiatzoglou A, Oulhaj A, Smith A, Nurk E, Drevon C, Ueland P, et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem 2009;55:2198-206.
21. Rasmussen K, Vyberg B, Pedersen K, Brochner-Mortense J. Methylmalonic acid in renal insufficiency - evidence of accumulation and implications for diagnosis of cobalamin deficiency. Clin Chem 1990;36:1523-4.
22. Galloway M, Hamilton M. Macrocytosis: pitfalls in testing and summary of guidance. BMJ 2007;335:884-6.
23. 12 and folate. Clinical Knowledge Summaries. www.cks.nice.org.uk.
24. Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008;112: 2214-21.
25. British Medical Association, Royal Pharmaceutical Society of Great Britain. British national formulary. www.medicinescomplete.com/mc/bnf/current/PHP5867-drugs-used-in-megaloblastic-anaemias.htm.
26. 12. BMJ 1968;3:102.
27. James J, Warin R. Sensitivity to cyanocobalamin and hydroxocobalamin. BMJ 1971;2:262.
28. 12 deficiency. Cochrane Database Syst Rev 2005;3:CD004655.
29. Finch C, Coleman D, Motulsky A, Donohue D, Reiff R. Erythrokinetics in pernicious anemia. Blood 1956;11:807-20.
30. Quadros E, Nakayama Y, Sequeira J. The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin. Blood 2009;113:186-92.
31. National Institutes of Health. Office of Dietary Supplements. US government, 2011. http://ods.od.nih.gov/pdf/factsheets/VitaminB12-HealthProfessional.pdf.