Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation

Kidney International

Volumn 86, Issue 5, 2014, Pages 1039-1048

  Kosmoliaptsis, Vasilios ^a   Gjorgjimajkoska, Olivera ^a   Sharples, Linda D ^b   Chaudhry, Afzal N ^c   Chatzizacharias, Nikolaos ^a   Peacock, Sarah ^c   Torpey, Nicholas ^c   Bolton, Eleanor M ^a   Taylor, Craig J ^c   Bradley, J Andrew ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

HLA; immunosuppression; matching; nephrectomy; re transplantation; sensitization

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA D ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; ALLOANTIBODY; BIOLOGICAL MARKER; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; AGED; ANTIBODY SCREENING; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; KIDNEY DONOR; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NEPHRECTOMY; ORGAN DONOR; RISK REDUCTION; SENSITIZATION; ADVERSE EFFECTS; BLOOD; CHILD; DONOR; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY TEST; IMMUNOLOGY; INFANT; MIDDLE AGED; NEWBORN; ODDS RATIO; PRESCHOOL CHILD; RECURRENT DISEASE; RISK FACTOR; TIME; TREATMENT FAILURE; YOUNG ADULT;

ADOLESCENT; ADULT; BIOMARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY TESTING; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-C ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INFANT, NEWBORN; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; ODDS RATIO; RECURRENCE; RISK FACTORS; TIME FACTORS; TISSUE DONORS; TREATMENT FAILURE; WAITING LISTS; YOUNG ADULT;

EID: 84908606674     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2014.106     Document Type: Article

References (30)

1. Opelz G, Dohler B. Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 2007; 84: 137-143
2. Fuggle SV, Allen JE, Johnson RJ, et al. Factors affecting graft and patient survival after live donor kidney transplantation in the UK. Transplantation 2010; 89: 694-701
3. Kobayashi E, Lord R, Green M, et al. Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection. Transplant Proc 1999; 31: 3409-3413
4. Taylor CJ, Welsh KI, Gray CM, et al. Clinical and socioeconomic benefits of serological HLA-DR matching for renal transplantation over three eras of immunosuppression regimens at a single unit. In: Terasaki PL, Cecka JM (Eds.) Clin Transpl 1993 UCLA Tissue Typing Laboratory, Los Angeles, California 1994: 233-241
5. Claas FH, Rahmel A, Doxiadis II. Enhanced kidney allocation to highly sensitized patients by the acceptable mismatch program. Transplantation 2009; 88: 447-452
6. Kosmoliaptsis V, Dafforn TR, Chaudhry AN, et al. High-resolution, threedimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes. Hum Immunol 2011; 72: 1049-1059
7. Claas FH, Doxiadis II. Management of the highly sensitized patient. Curr Opin Immunol 2009; 21: 569-572
8. Bostock IC, Alberu J, Arvizu A, et al. Probability of deceased donor kidney transplantation based on % PRA. Transpl Immunol 2013; 28: 154-158
9. Salvadori M, Bertoni E. Renal transplant allocation criteria, desensitization strategies and immunosuppressive therapy in retransplant renal patients. J Nephrol 2012; 25: 890-899
10. Sanfilippo F, Goeken N, Niblack G, et al. The effect of first cadaver renal transplant HLA-A, B match on sensitization levels and retransplant rates following graft failure. Transplantation 1987; 43: 240-244
11. Matas AJ, Frey DJ, Gillingham KJ, et al. The impact of HLA matching on graft survival and on sensitization after a failed transplant-evidence that failure of poorly matched renal transplants does not result in increased sensitization. Transplantation 1990; 50: 599-607
12. Scornik JC, Kriesche HU. Human leukocyte antigen sensitization after transplant loss: timing of antibody detection and implications for prevention. Hum Immunol 2011; 72: 398-401
13. Taylor CJ, Kosmoliaptsis V, Summers DM, et al. Back to the future: application of contemporary technology to long-standing questions about the clinical relevance of human leukocyte antigen-specific alloantibodies in renal transplantation. Hum Immunol 2009; 70: 563-568
14. Meier-Kriesche HU, Scornik JC, Susskind B, et al. A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patients. Transplantation 2009; 88: 23-29
15. Gralla J, Tong S, Wiseman AC. The impact of human leukocyte antigen mismatching on sensitization rates and subsequent retransplantation after first graft failure in pediatric renal transplant recipients. Transplantation 2013; 95: 1218-1224
16. Fuggle SV, Martin S. Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients. Transplantation 2008; 86: 384-390
17. Vaidya S. Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches. Transplantation 2008; 85: 1046-1050
18. Wu P, Jin J, Everly MJ, et al. Impact of alloantibody strength in crossmatch negative DSA positive kidney transplantation. Clin Biochem 2013; 46: 1389-1393
19. Susal C, Ovens J, Mahmoud K, et al. No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-Antigen testing: a Collaborative Transplant Study report. Transplantation 2011; 91: 883-887
20. Claas FH. HLA antibody testing: a tool to facilitate not to prevent organ transplantation. Int J Immunogenet 2008; 35: 275-277
21. Lobashevsky AL, Higgins NG, Rosner KM, et al. Analysis of anti-HLA antibodies in sensitized kidney transplant candidates subjected to desensitization with intravenous immunoglobulin and rituximab. Transplantation 2013; 96: 182-190
22. Augustine JJ, Woodside KJ, Padiyar A, et al. Independent of nephrectomy, weaning immunosuppression leads to late sensitization after kidney transplant failure. Transplantation 2012; 94: 738-743
23. Del Bello A, Congy N, Sallusto F, et al. Anti-human leukocyte antigen immunization after early allograft nephrectomy. Transplantation 2012; 93: 936-941
24. Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006; 67: 847-862
25. Dankers MK, Witvliet MD, Roelen DL, et al. The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens. Transplantation 2004; 77: 1236-1239
26. Kosmoliaptsis V, Bradley JA, Sharples LD, et al. Predicting the immunogenicity of human leukocyte antigen class I alloantigens using structural epitope analysis determined by HLAMatchmaker. Transplantation 2008; 85: 1817-1825
27. Kosmoliaptsis V, Chaudhry AN, Sharples LD, et al. Predicting HLA class I alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms. Transplantation 2009; 88: 791-798
28. Howell WM, Harmer A, Briggs D, et al. British Society for Histocompatibility &Immunogenetics and British Transplantation Society Guidelines for the detection and characterisation of clinically relevant antibodies in allotransplantation. Int J Immunogenet 2010; 37: 435-437
29. Everitt B. The Analysis of Contingency Tables. Chapman &Hall: London, 1977
30. Long S. Regression Models for Categorical and Limited Dependent Variables. SAGE Publications: Thousand Oaks, CA, 1997