Detection of lung cancer through low-dose CT screening (NELSON): A prespecified analysis of screening test performance and interval cancers

The Lancet Oncology

Volumn 15, Issue 12, 2014, Pages 1342-1350

  Horeweg, Nanda ^a   Scholten, Ernst Th ^b   de Jong, Pim A ^c   van der Aalst, Carlijn M ^a   Weenink, Carla ^b   Lammers, Jan Willem J ^c   Nackaerts, Kristiaan ^d   Vliegenthart, Rozemarijn ^e   ten Haaf, Kevin ^a   Yousaf Khan, Uraujh A ^a   Heuvelmans, Marjolein A ^e   Thunnissen, Erik ^f   Oudkerk, Matthijs ^e   Mali, Willem ^c   de Koning, Harry J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Infection and Immunology   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER REGISTRY; CANCER SCREENING; CANCER STAGING; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FOLLOW UP; HUMAN; LOW ENERGY RADIATION; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PROTOCOL COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SMOKING; VOLUMETRY; EARLY DIAGNOSIS; LUNG; LUNG NEOPLASMS; PATHOLOGY; RADIOGRAPHY; RETROSPECTIVE STUDY;

AGED; EARLY DETECTION OF CANCER; FEMALE; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SMOKING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84908592946     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(14)70387-0     Document Type: Article

References (37)

1. Kaneko M, Eguchi K, Ohmatsu H, et al. Peripheral lung cancer: screening and detection with low-dose CT versus radiography. Radiology 1996, 201:798-802.
2. Sone S, Takashina S, Li F, et al. Mass screening for lung cancer with mobile spiral computed tomography scanner. Lancet 1998, 351:1242-1245.
3. Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet 1999, 354:99-105.
4. Pastorino U, Bellomi M, Landoni C, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003, 362:593-597.
5. Swensen SJ, Jett JR, Hartman TE, et al. CT screening for lung cancer: five-year prospective experience. Radiology 2005, 235:259-265.
6. Sone S, Li F, Yang ZG, et al. Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer 2001, 84:25-32.
7. Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011, 365:395-409.
8. de Koning HJ, Meza R, Plevritis SK, et al. Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force. Ann Intern Med 2013, 159:411-420.
9. Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB Screening for lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013, 143(5 suppl):e78S-e92S.
10. Humphrey LL, Deffebach M, Pappas M, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the US Preventive Services Task Force recommendation. Ann Intern Med 2013, 159:411-420.
11. Saghir Z, Dirksen A, Ashraf H, et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax 2012, 67:296-301.
12. Infante M, Chiesa G, Solomon D, et al. Surgical procedures in the DANTE trial; a randomized study of lung cancer early detection with spiral computed tomography: comparative analysis in the screening and the control arm. J Thorac Oncol 2011, 6:327-335.
13. Pastorino U, Rossi M, Rosato V, et al. Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur J Cancer Prev 2012, 21:308-315.
14. Church TR, Black WC, et al. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med 2013, 368:1980-1991. National Lung Screening Trial Research Team.
15. Aberle DR, DeMello S, Berg CD, et al. Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med 2013, 369:920-931.
16. Becker N, Motsch E, Gross ML, et al. Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round. J Cancer Res Clin Oncol 2012, 138:1475-1486.
17. Horeweg N, van der Aalst CM, Vliegenthart R, et al. Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial. Eur Respir J 2013, 42:1659-1667.
18. van Iersel CA, de Koning HJ, Draisma G, et al. Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON). Int J Cancer 2007, 120:868-874.
19. Bankier AA, Kressel HY Through the Looking Glass revisited: the need for more meaning and less drama in the reporting of dose and dose reduction in CT. Radiology 2012, 265:4-8.
20. Xu DM, Gietema H, de Koning H, et al. Nodule management protocol of the NELSON randomised lung cancer screening trial. Lung Cancer 2006, 54:177-184.
21. Ru Zhao Y, Xie X, de Koning HJ, Mali WP, Vliegenthart R, Oudkerk M NELSON lung cancer screening study. Cancer Imaging 2011, 11(Spec No A):S79-S84.
22. van Meerbeeck JP, Koning CC, Tjan-Heijnen VC, Boekema AG, Kaandorp CJ, Burgers JS Guideline on 'non-small cell lung carcinoma; staging and treatment'. Ned Tijdschr Geneeskd 2005, 149:72-77.
23. van 't Westeinde SC, Horeweg N, Vernhout RM, et al. The role of conventional bronchoscopy in the workup of suspicious CT scan screen-detected pulmonary nodules. Chest 2012, 142:377-384.
24. van't Westeinde SC, de Koning HJ, Thunnissen FB, et al. The role of the (18-fluorodeoxyglucose)-positron emission tomography scan in the Nederlands Leuvens Longkanker screenings Onderzoek lung cancer screening trial. J Thorac Oncol 2011, 6:1704-1712.
25. Nederland IKC The Dutch Cancer Registry (accessed Sept 2, 2014; in Dutch). http://www.cijfersoverkanker.nl/about-cancer-registry-37.html.
26. Horeweg N, van Klaveren RJ, Groen HJ, et al. Blinded and uniform cause of death verification in a lung cancer CT screening trial. Lung Cancer 2012, 77:522-525.
27. Goldstraw P, Crowley J, Chansky K, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007, 2:706-714.
28. Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC Pathology and genetics. Tumours of the lung, pleura, thymus and heart 2004, IARC Press, Geneva.
29. Lopes Pegna A, Picozzi G, Mascalchi M, et al. Design, recruitment and baseline results of the ITALUNG trial for lung cancer screening with low-dose CT. Lung Cancer 2009, 64:34-40.
30. van Klaveren RJ, Oudkerk M, Prokop M, et al. Management of lung nodules detected by volume CT scanning. N Engl J Med 2009, 361:2221-2229.
31. Xie X, Zhao Y, Snijder RA, et al. Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study. Eur Radiol 2013, 23:139-147.
32. Horeweg N, Nackaerts K, Oudkerk M, de Koning HJ Low-dose computed tomography screening for lung cancer: results of the first screening round. J Comp Eff Res 2013, 2:433-436.
33. Duffy SW, Field JK, Allgood PC, Seigneurin A Translation of research results to simple estimates of the likely effects of a lung cancer screening programme in the United Kingdom. Br J Cancer 2014, 110:1834-1840.
34. Scholten ET, Horeweg N, de Koning HJ, et al. Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening. Eur Radiol (in press).
35. Henschke CI, Yip R, Yankelevitz DF, Smith JP Definition of a positive test result in computed tomography screening for lung cancer: a cohort study. Ann Intern Med 2013, 158:246-252. International Early Lung Cancer Action Program Investigators.
36. Horeweg N, van der Aalst CM, Thunnissen E, et al. Characteristics of lung cancers detected by computer tomography screening in the randomized NELSON trial. Am J Respir Crit Care Med 2013, 187:848-854.
37. Pinsky PF, Church TR, Izmirlian G, Kramer BS The National Lung Screening Trial: results stratified by demographics, smoking history, and lung cancer histology. Cancer 2013, 119:3976-3983.