Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung

Pediatric Research

Volumn 76, Issue 5, 2014, Pages 441-447

  Schmidt, Augusto F ^a   Kannan, Paranthaman S ^a   Kemp, Matthew W ^b   Kramer, Boris W ^c   Newnham, John P ^b   Jobe, Alan H ^a   Kallapur, Suhas G ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; BETA DEFENSIN 1; BETA DEFENSIN 2; DAMAGE ASSOCIATED MOLECULAR PATTERN; DODECAPEPTIDE; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTOFERRIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID ANTIMICROBIAL PEPTIDE 29; PEPTIDE; PEPTIDES AND PROTEINS; POLYPEPTIDE ANTIBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; AUTACOID; CYTOKINE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHORIOAMNIONITIS; CONTROLLED STUDY; FEMALE; FETUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG ALVEOLUS CELL; MALE; NONHUMAN; PNEUMONIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AMNION FLUID; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; LUNG; METABOLISM; PREGNANCY; PREMATURITY; SHEEP; TIME FACTOR;

AMNIOTIC FLUID; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CHORIOAMNIONITIS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GESTATIONAL AGE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; PREGNANCY; PREMATURE BIRTH; RNA, MESSENGER; SHEEP; TIME FACTORS;

EID: 84908564313     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.113     Document Type: Article

References (40)

1. Kemp MW, Kannan PS, Saito M, et al. Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep. PLoS One 2013;8:e63355.
2. Lahra MM, Beeby PJ, Jeffery HE. Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study. Pediatrics 2009;123:1314-9.
3. Viscardi RM, Muhumuza CK, Rodriguez A, et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Res 2004;55:1009-17.
4. Hartling L, Liang Y, Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2012;97:F8-F17.
5. Willet KE, Kramer BW, Kallapur SG, et al. Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung. Am J Physiol Lung Cell Mol Physiol 2002;282:L411-20.
6. Kallapur SG, Nitsos I, Moss TJ, et al. Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs. Am J Physiol Lung Cell Mol Physiol 2005;288:L966-74.
7. Kallapur SG, Nitsos I, Moss TJ, et al. IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide. Am J Respir Crit Care Med 2009;179:955-61.
8. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140:805-20.
9. Hillman NH, Moss TJ, Nitsos I, et al. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res 2008;63: 388-93.
10. Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010;10:826-37.
11. Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol 2009;30:131-41.
12. Doss M, White MR, Tecle T, Hartshorn KL. Human defensins and LL-37 in mucosal immunity. J Leukoc Biol 2010;87:79-92.
13. Meyerholz DK, Kawashima K, Gallup JM, Grubor B, Ackermann MR. Expression of select immune genes (surfactant proteins A and D, sheep beta defensin 1, and toll-like receptor 4) by respiratory epithelia is developmentally regulated in the preterm neonatal lamb. Dev Comp Immunol 2006;30:1060-9.
14. Meyerholz DK, Gallup JM, Grubor BM, et al. Developmental expression and distribution of sheep beta-defensin-2. Dev Comp Immunol 2004;28:171-8.
15. Menard S, Forster V, Lotz M, et al. Developmental switch of intestinal antimicrobial peptide expression. J Exp Med 2008;205:183-93.
16. Kuypers E, Wolfs TG, Collins JJ, et al. Intraamniotic lipopolysaccharide exposure changes cell populations and structure of the ovine fetal thymus. Reprod Sci 2013;20:946-56.
17. Kramer BW, Kramer S, Ikegami M, Jobe AH. Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol 2002;283:L452-9.
18. Singh PK, Jia HP, Wiles K, et al. Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci USA 1998;95:14961-6.
19. Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun 2000;68:113-9.
20. Grubor B, Gallup JM, Meyerholz DK, et al. Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clin Diagn Lab Immunol 2004;11:599-607.
21. Ackermann MR, Gallup JM, Zabner J, et al. Differential expression of sheep beta-defensin-1 and-2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microb Pathog 2004;37:21-7.
22. Tjabringa GS, Rabe KF, Hiemstra PS. The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung. Pulm Pharmacol Ther 2005;18:321-7.
23. Travis SM, Anderson NN, Forsyth WR, et al. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun 2000;68:2748-55.
24. Morioka Y, Yamasaki K, Leung D, Gallo RL. Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis. J Immunol 2008;181:3915-22.
25. Mookherjee N, Brown KL, Bowdish DM, et al. Modulation of the TLRmediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol 2006;176:2455-64.
26. Baroni A, Donnarumma G, Paoletti I, et al. Antimicrobial human betadefensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells. Peptides 2009;30:267-72.
27. Aarbiou J, Ertmann M, van Wetering S, et al. Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol 2002;72:167-74.
28. van Wetering S, Tjabringa GS, Hiemstra PS. Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells. J Leukoc Biol 2005;77:444-50.
29. Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 2003;111:1665-72.
30. Tjabringa GS, Aarbiou J, Ninaber DK, et al. The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 2003;171:6690-6.
31. Kallapur SG, Bachurski CJ, Le Cras TD, Joshi SN, Ikegami M, Jobe AH. Vascular changes after intra-amniotic endotoxin in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol 2004;287:L1178-85.
32. Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011;117:3720-32.
33. Rider P, Carmi Y, Guttman O, et al. IL-1á and IL-1â recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol 2011;187:4835-43.
34. Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature 2002;417:552-5.
35. Kruzel ML, Harari Y, Mailman D, Actor JK, Zimecki M. Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice. Clin Exp Immunol 2002;130:25-31.
36. Hillman NH, Kallapur SG, Pillow JJ, et al. Airway injury from initiating ventilation in preterm sheep. Pediatr Res 2010;67:60-5.
37. Wheeler DS, Wong HR. Heat shock response and acute lung injury. Free Radic Biol Med 2007;42:1-14.
38. Shah TA, Hillman NH, Nitsos I, et al. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res 2010;68:210-5.
39. Kallapur SG, Willet KE, Jobe AH, Ikegami M, Bachurski CJ. Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs. Am J Physiol Lung Cell Mol Physiol 2001;280:L527-36.
40. Kallapur SG, Kramer BW, Nitsos I, et al. Pulmonary and systemic inflammatory responses to intra-amniotic IL-1 in fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011;301:L285-95