A decade of discovery in cancer genomics

Nature Reviews Clinical Oncology

Volumn 11, Issue 11, 2014, Pages 632-634

  Offit, Kenneth ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CANCER GENETICS; CANCER SCREENING; CANCER SUSCEPTIBILITY; CANCER SUSCEPTIBILITY SYNDROME; FAMILIAL CANCER; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETIC VARIABILITY; GENOMICS; HUMAN; INCIDENTAL FINDING; INFORMED CONSENT; NEXT GENERATION SEQUENCING; OVARY CANCER; SALPINGOOOPHORECTOMY; SEQUENCE ANALYSIS; SHORT SURVEY; SINGLE NUCLEOTIDE POLYMORPHISM; SYNDROME; TUMOR SUPPRESSOR GENE; ANIMAL; CARCINOGENESIS; GENETICS; HUMAN GENOME; NEOPLASM METASTASIS; NEOPLASMS; TRENDS;

ANIMALS; CARCINOGENESIS; GENOME, HUMAN; GENOMICS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 84908506580     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2014.170     Document Type: Short Survey

References (10)

1. Couch, F. J., Nathanson, K. L. & Offit, K. Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343, 1466-1470 (2014).
2. Domchek, S. M. et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 304, 967-975 (2010).
3. Easton, D. F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087-1093 (2007).
4. Stadler, K., Schrader, K. A., Vijai, J., Robson, M. E. & Offit, K. Cancer genomics and inherited risk. J. Clin. Oncol. 32, 687-698 (2014).
5. Gaudet, M. M. et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 9, e1003173 (2013).
6. Walsh, T. et al. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc. Natl Acad. Sci. USA 108, 18032-18037 (2011).
7. Jones, S. et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324, 217 (2009).
8. Testa, J. R. et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat. Genet. 43, 1022-1025 (2011).
9. Shah, S. et al. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat. Genet. 45, 1226-1231 (2013).
10. Bombard, Y., Robson, M. & Offit, K. Revealing the incidentalome when targeting the tumor genome. JAMA 310, 795-796 (2013).