Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis

Kidney International Supplements

Volumn 4, Issue 1, 2014, Pages 65-69

  Ostendorf, Tammo ^a   Boor, Peter ^a,b   Van Roeyen, Claudia R C ^a   Floege, Jürgen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Faculty of Natural Sciences   (Slovakia)

Author keywords

extracellular matrix; glomerulosclerosis; mesangial cell; mesenchymal cells; myofibroblast

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

FIBROGENESIS; GENE SILENCING; GLOMERULOPATHY; GLOMERULOSCLEROSIS; HEALTH; HUMAN; KIDNEY FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

EID: 84908501497     PISSN: 21571724     EISSN: 21571716     Source Type: Journal    
DOI: 10.1038/kisup.2014.12     Document Type: Short Survey

References (35)

1. Boor P, Ostendorf T, Floege J. Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 2010; 6: 643-656.
2. Boor P, Sebekova K, Ostendorf T et al. Treatment targets in renal fibrosis. Nephrol Dial Transplant 2007; 22: 3391-3407.
3. Ostendorf T, Eitner F, Floege J. The PDGF family in renal fibrosis. Pediatr Nephrol 2012; 27: 1041-1050.
4. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22: 1276-1312.
5. Jechlinger M, Sommer A, Moriggl R et al. Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 2006; 116: 1561-1570.
6. Floege J, Eitner F, Alpers CE. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol 2008; 19: 12-23.
7. Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev 2004; 15: 205-213.
8. Boor P, van Roeyen CR, Kunter U et al. PDGF-C mediates glomerular capillary repair. Am J Pathol 2010; 177: 58-69.
9. Eitner F, Ostendorf T, Van Roeyen C et al. Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney. J Am Soc Nephrol 2002; 13: 910-917.
10. Eitner F, Ostendorf T, Kretzler M et al. PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases. J Am Soc Nephrol 2003; 14: 1145-1153.
11. Changsirikulchai S, Hudkins KL, Goodpaster TA et al. Platelet-derived growth factor-D expression in developing and mature human kidneys. Kidney Int 2002; 62: 2043-2054.
12. Ostendorf T, van Roeyen CR, Peterson JD et al. A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis. J Am Soc Nephrol 2003; 14: 2237-2247.
13. Taneda S, Hudkins KL, Topouzis S et al. Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol 2003; 14: 2544-2555.
14. Triantafyllopoulou A, Franzke CW, Seshan SV et al. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci USA 2010; 107: 3012-3017.
15. Liu G, Changsirikulchai S, Hudkins KL et al. Identification of plateletderived growth factor D in human chronic allograft nephropathy. Hum Pathol 2008; 39: 393-402.
16. Boor P, Eitner F, Cohen CD et al. Patients with IgA nephropathy exhibit high systemic PDGF-DD levels. Nephrol Dial Transplant 2009; 24: 2755-2762.
17. van Roeyen CR, Ostendorf T, Floege J. The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors. Eur J Cell Biol 2012; 91: 542-551.
18. Raines EW, Lane TF, Iruela-Arispe ML et al. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci USA 1992; 89: 1281-1285.
19. Abrass CK, Hansen KM, Patton BL. Laminin alpha4-null mutant mice develop chronic kidney disease with persistent overexpression of platelet-derived growth factor. Am J Pathol 2010; 176: 839-849.
20. Chiara F, Bishayee S, Heldin CH et al. Autoinhibition of the plateletderived growth factor beta-receptor tyrosine kinase by its C-terminal tail. J Biol Chem 2004; 279: 19732-19738.
21. van Roeyen CR, Eitner F, Scholl T et al. CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation. Kidney Int 2008; 73: 86-94.
22. van Roeyen CR, Zok S, Pruessmeyer J et al. Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation. Kidney Int 2013; 83: 251-263.
23. van Roeyen CR, Boor P, Borkham-Kamphorst E et al. A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects. Am J Pathol 2012; 180: 1979-1990.
24. Tang WW, Ulich TR, Lacey DL et al. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol 1996; 148: 1169-1180.
25. Hudkins KL, Gilbertson DG, Carling M et al. Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy. J Am Soc Nephrol 2004; 15: 286-298.
26. van Roeyen CR, Eitner F, Boor P et al. Induction of progressive glomerulonephritis by podocyte-specific overexpression of plateletderived growth factor-D. Kidney Int 2011; 80: 1292-1305.
27. Boor P, Konieczny A, Villa L et al. PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis. Nephrol Dial Transplant 2007; 22: 1323-1331.
28. Kong D, Li Y, Wang Z et al. miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 2009; 27: 1712-1721.
29. Chen YT, Chang FC, Wu CF et al. Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int 80: 1170-1181.
30. Wang S, Wilkes MC, Leof EB et al. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J 2005; 19: 1-11.
31. Kishioka H, Fukuda N, Wen-Yang H et al. Effects of PDGF A-chain antisense oligodeoxynucleotides on growth of cardiovascular organs in stroke-prone spontaneously hypertensive rats. Am J Hypertens 2001; 14: 439-445.
32. Eitner F, Bucher E, van Roeyen C et al. PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis. J Am Soc Nephrol 2008; 19: 281-289.
33. Martin IV, Borkham-Kamphorst E, Zok S et al. Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis. Am J Pathol 2013; 182: 107-117.
34. Seikrit C, Henkel C, van Roeyen CR et al. Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant 2013; 28: 889-900.
35. Hawthorne T, Giot L, Blake L et al. A phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D. Int J Clin Pharmacol Ther 2008; 46: 236-244.