Optimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterization

International Journal of Pharmaceutics

Volumn 477, Issue 1, 2014, Pages 39-46

  El Dahmy, Rania Moataz ^a   Elsayed, Ibrahim ^b,c   Elshafeey, Ahmed Hassen ^b,d   Gawad, Nabaweya Abdelaziz Abd El ^a   El Gazayerly, Omaima Naim ^b  

^a 6th of October   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c GULF MEDICAL UNIVERSITY   (United Arab Emirates)

^d UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Lyophilization; Mean residence time; Micelles; Pluronic; Sterilization; Vinpocetine; Vivo

Indexed keywords

POLOXAMER; VINPOCETINE; ANTIHYPERTENSIVE AGENT; DRUG CARRIER; MICELLE; NANOPARTICLE; POLYMER; VINCA ALKALOID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; FREEZE DRYING; IN VITRO STUDY; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICELLE; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; POLYMERIZATION; PROCESS OPTIMIZATION; RABBIT; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG RELEASE; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PROCEDURES;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG LIBERATION; FREEZE DRYING; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MICELLES; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POLYMERS; RABBITS; VINCA ALKALOIDS;

EID: 84908463471     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.10.003     Document Type: Article

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