Dopamine beta-hydroxylase gene modulates individuals' empathic ability

Social Cognitive and Affective Neuroscience

Volumn 9, Issue 9, 2013, Pages 1341-1345

  Gong, Pingyuan ^a,b   Liu, Jinting ^a   Li, She ^b   Zhou, Xiaolin ^a  

^a PEKING UNIVERSITY   (China)

^b HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

1021C T; DBH; Dopamine beta hydroxylase; Empathy; Polymorphism

Indexed keywords

DOPAMINE BETA MONOOXYGENASE;

ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; EMPATHY; ETHNOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; INDIVIDUALITY; MALE; PSYCHOLOGIC TEST; YOUNG ADULT;

ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; DOPAMINE BETA-HYDROXYLASE; EMPATHY; FEMALE; GENOTYPE; HUMANS; INDIVIDUALITY; MALE; POLYMORPHISM, GENETIC; PSYCHOLOGICAL TESTS; YOUNG ADULT;

EID: 84908452371     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nst122     Document Type: Article

References (43)

1. Adams, R.B., Rule, N.O., Franklin, R.G., et al. (2010). Cross-cultural reading the mind in the eyes: an fMRI investigation. Journal of Cognitive Neuroscience, 22, 97-108.
2. Baron-Cohen, S., Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34, 163-75.
3. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., Plumb, I. (2001). The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 42, 241-51.
4. Batson, C.D. (2008). These things called empathy: eight related but distinct phenomena. In: Decety, J., Lckes, W., editors. The Social Neuroscience of Empathy. Cambridge, MA: The MIT Press, pp. 3-15.
5. Bassett, A.S., Caluseriu, O., Weksberg, R., Young, D.A., Chow, E.W.C. (2007). Catechol-Omethyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome. Biological Psychiatry, 61, 1135-40.
6. Bernhardt, B.C., Singer, T. (2012). The neural basis of empathy. Annual Review of Neuroscience, 35, 1-23.
7. Craig, S.P., Buckle, V.J., Lamouroux, A., Mallet, J., Craig, I.W. (1988). Localization of the human dopamine beta hydroxylase (DBH) gene to chromosome 9q34. Cytogenetics and Cell Genetics, 48, 48-50.
8. Cubells, J.F., Kranzler, H.R., McCance-Katz, E., et al. (2000). A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia. Molecular Psychiatry, 5, 56-63.
9. Dapretto, M., Davies, M.S., Pfeifer, J.H., et al. (2006). Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9, 28-30.
10. Davis, M.H. (1980). A multidimensional approach to individual differences in empathy. JSAS: Catalog of Selected Documents in Psychology, 10, 85.
11. Davis, M.H. (1983). Measuring individual differences in empathy: evidence for a multidimensional approach. Journal of Personality and Social Psychology, 44, 113-26.
12. de Lamballerie, X., Chapel, F., Vignoli, C., Zandotti, C. (1994). Improved current methods for amplification of DNA from routinely processed liver tissue by PCR. Journal of Clinical Pathology, 47, 466-7.
13. Domes, G., Heinrichs, M., Michel, A., Berger, C., Herpertz, S.C. (2007). Oxytocin improves "mind-reading" in humans. Biological Psychiatry, 61, 731-3.
14. Duchenne, G.B., Cuthbertson, R.A., editors. (1990). The Mechanisms of Human Facial Expression or an Electrophysiological Analysis of the Expression of the Emotions. New York: Cambridge University Press.
15. Dziobek, I., Rogers, K., Fleck, S., et al. (2008). Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). Journal of Autism and Developmental Disorders, 38, 464-73.
16. Harmer, C.J., O'Sullivan, U., Favaron, E., et al. (2009). Effect of acute antidepressant administration on negative affective bias in depressed patients. The American Journal of Psychiatry, 166, 1178-84.
17. Jack, R.E., Garrod, O.G.B., Yu, H., Caldara, R., Schyns, P.G. (2012). Facial expressions of emotion are not culturally universal. Proceedings of the National Academy of Sciences of the United States of America, 109, 7241-4.
18. Kim, H.S., Sherman, D.K., Mojaverian, T., et al. (2011). Gene-culture interaction: oxytocin receptor polymorphism (OXTR) and emotion regulation. Social Psychological and Personality Science, 2, 665-72.
19. Kim, H.S., Sherman, D.K., Sasaki, J.Y., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences of the United States of America, 107, 15717-21.
20. Knafo, A., Zahn-Waxler, C., Van Hulle, C., Robinson, J.L., Rhee, S.H. (2008). The developmental origins of a disposition toward empathy: genetic and environmental contributions. Emotion, 8, 737-52.
21. Kobayashi, K., Kurosawa, Y., Fujita, K., Nagatsu, T. (1989). Human dopamine beta-hydroxylase gene: two mRNA types having different 3'-terminal regions are produced through alternative polyadenylation. Nucleic Acids Research, 17, 1089-102.
22. Kucharska-Pietura, K., Tylec, A., Czernikiewicz, A., Mortimer, A. (2012). Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs. Medical Science Monitor, 18, CR44-49.
23. Lake, C.R., Ziegler, M.G., Murphy, D.L. (1977). Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism. Archives of General Psychiatry, 34, 553-6.
24. Marino, M.D., Bourdélat-Parks, B.N., Cameron Liles, L., Weinshenker, D. (2005). Genetic reduction of noradrenergic function alters social memory and reduces aggression in mice. Behavioural Brain Research, 161, 197-203.
25. Mehrabian, A., Young, A.L., Sato, S. (1988). Emotional empathy and associated individual differences. Current Psychology, 7, 221-240.
26. Narme, P., Mouras, H., Roussel, M., Duru, C., Krystkowiak, P., Godefroy, O. (2013). Emotional and cognitive social processes are impaired in Parkinson's disease and are related to behavioral disorders. Neuropsychology, 27, 182-92.
27. O'Brien, E., Konrath, S.H., Grühn, D., Hagen, A.L. (2013). Empathic concern and perspective taking: linear and quadratic effects of age across the adult life span. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 68, 168-75.
28. Oxenstierna, G., Edman, G., Iselius, L., Oreland, L., Ross, S.B., Sedvall, G. (1986). Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals-a genetic study. Journal of Psychiatric Research, 20, 19-29.
29. Rankin, K.P., Gorno-Tempini, M.L., Allison, S.C., et al. (2006). Structural anatomy of empathy in neurodegenerative disease. Brain, 129, 2945-56.
30. Reuter, M., Frenzel, C., Walter, N.T., Markett, S., Montag, C. (2011). Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism. Social Cognitive and Affective Neuroscience, 6, 662-8.
31. Robertson, D., Goldberg, M.R., Onrot, J., et al. (1986). Isolated failure of autonomic noradrenergic neurotransmission. Evidence for impaired beta-hydroxylation of dopamine. The New England Journal of Medicine, 314, 1494-7.
32. Robinson, P.D., Schutz, C.K., Macciardi, F., White, B.N., Holden, J.J. (2001). Genetically determined low maternal serum dopamine beta-hydroxylase levels and the etiology of autism spectrum disorders. American Journal of Medical Genetics, 100, 30-6.
33. Rodrigues, S.M., Saslow, L.R., Garcia, N., John, O.P., Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences of the United States of America, 106, 21437-41.
34. Shamay-Tsoory, S.G. (2008). Empathic processing: its cognitive and affective dimensions and neuroanatomical basis. In: Decety, J., Lckes, W., editors. The Social Neuroscience of Empathy. Cambridge, MA: The MIT Press, pp. 215-32.
35. Shamay-Tsoory, S.G., Shur, S., Harari, H., Levkovitz, Y. (2007). Neurocognitive basis of impaired empathy in schizophrenia. Neuropsychology, 21, 431-8.
36. Smith, M.J., Horan, W.P., Karpouzian, T.M., Abram, S.V., Cobia, D.J., Csernansky, J.G. (2012). Self-reported empathy deficits are uniquely associated with poor functioning in schizophrenia. Schizophrenia Research, 137, 196-202.
37. Thomas, S.A., Palmiter, R.D. (1997). Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Cell, 91, 583-92.
38. Thomas, S.A., Marck, B.T., Palmiter, R.D., Matsumoto, A.M. (1998). Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. Journal of Neurochemistry, 70, 2468-76.
39. Tse, W.S., Bond, A.J. (2003). Reboxetine promotes social bonding in healthy volunteers. Journal of Psychopharmacology, 17, 189-95.
40. Tsuruya, N., Kobayakawa, M., Kawamura, M. (2011). Is "reading mind in the eyes" impaired in Parkinson's disease? Parkinsonism and Related Disorders, 17, 246-8.
41. van Honk, J., Schutter, D.J., Bos, P.A., Kruijt, A.-W., Lentjes, E.G., Baron-Cohen, S. (2011). Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio. Proceedings of the National Academy of Sciences of the United States of America, 108, 3448-52.
42. Vellante, M., Baron-Cohen, S., Melis, M., et al. (2012). The "Reading the Mind in the Eyes" test: systematic review of psychometric properties and a validation study in Italy. Cognitive Neuropsychiatry, 2012, 1-29.
43. Zabetian, C.P., Anderson, G.M., Buxbaum, S.G., et al. (2001). A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. American Journal of Human Genetics, 68, 515-22.