High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization

International Journal of Pharmaceutics

Volumn 477, Issue 1-2, 2014, Pages 361-368

  Kastner, Elisabeth ^a   Kaur, Randip ^a   Lowry, Deborah ^a   Moghaddam, Behfar ^a   Wilkinson, Alexander ^a   Perrie, Yvonne ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Design of experiment; DNA delivery; High throughput manufacturing; Liposomes; Microfluidics

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; DIOLEOYLPHOSPHATIDYLCHOLINE; LIPOSOME; SOLVENT; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; 1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; DNA; DRUG CARRIER; MONOUNSATURATED FATTY ACID; PHOSPHATIDYLETHANOLAMINE; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MANUFACTURE; FLOW RATE RATIO; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MATHEMATICAL MODEL; MICROFLUIDICS; NONHUMAN; PARTICLE SIZE; SYNTHESIS; TOTAL FLOW RATE; VOLUMETRY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETIC TRANSFECTION; GENETICS; MULTIVARIATE ANALYSIS; PHARMACEUTICS; PROCEDURES; STATISTICS AND NUMERICAL DATA;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DRUG CARRIERS; FATTY ACIDS, MONOUNSATURATED; HIGH-THROUGHPUT SCREENING ASSAYS; LIPOSOMES; MICROFLUIDICS; MULTIVARIATE ANALYSIS; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; QUATERNARY AMMONIUM COMPOUNDS; TECHNOLOGY, PHARMACEUTICAL; TRANSFECTION;

EID: 84908439571     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.10.030     Document Type: Article

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