메뉴 건너뛰기




Volumn 99, Issue 11, 2014, Pages 1738-1745

ANTI-CD22 90y-epratuzumab tetraxetan combined with anti-cd20 veltuzumab: A phase I study in patients with relapsed/refractory, aggressive non-hodgkin lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

EPRATUZUMAB TETRAXETAN YTTRIUM Y 90; FLUORODEOXYGLUCOSE F 18; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VELTUZUMAB; ANTINEOPLASTIC AGENT; EPRATUZUMAB; INDIUM; MONOCLONAL ANTIBODY; YTTRIUM;

EID: 84908410053     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.112110     Document Type: Article
Times cited : (26)

References (41)
  • 1
    • 49349095724 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma
    • Cheson BD, Leonard JP. Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma. N Engl J Med. 2008;359(6):613-26.
    • (2008) N Engl J Med , vol.359 , Issue.6 , pp. 613-626
    • Cheson, B.D.1    Leonard, J.P.2
  • 2
    • 77953507105 scopus 로고    scopus 로고
    • The future of CD20 monoclonal antibody therapy in B-cell malignancies
    • Czuczman MS, Gregory SA. The future of CD20 monoclonal antibody therapy in B-cell malignancies. Leuk Lymphoma. 2010;51 (6):983-94.
    • (2010) Leuk Lymphoma , vol.51 , Issue.6 , pp. 983-994
    • Czuczman, M.S.1    Gregory, S.A.2
  • 4
    • 78651376557 scopus 로고    scopus 로고
    • New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies
    • Robak T, Robak E. New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies. BioDrugs. 2011;25 (1):13-25.
    • (2011) BioDrugs , vol.25 , Issue.1 , pp. 13-25
    • Robak, T.1    Robak, E.2
  • 5
    • 84867236304 scopus 로고    scopus 로고
    • Novel CD20 monoclonal antibodies for lymphoma 90Y-epratuzumab tetraxetan plus veltuzumab in NHL therapy
    • Cang S, Mukhi N, Wang K, Liu D. Novel CD20 monoclonal antibodies for lymphoma 90Y-epratuzumab tetraxetan plus veltuzumab in NHL therapy. J Hematol Oncol. 2012; 5:64. doi: 10.1186/1756-8722-5-64
    • (2012) J Hematol Oncol , vol.5 , pp. 64
    • Cang, S.1    Mukhi, N.2    Wang, K.3    Liu, D.4
  • 6
    • 55949090288 scopus 로고    scopus 로고
    • Evidence mounts for the efficacy of radioimmunotherapy for B-cell lym-phomas
    • Press OW. Evidence mounts for the efficacy of radioimmunotherapy for B-cell lym-phomas. J Clin Oncol. 2008;26(32):5147-50.
    • (2008) J Clin Oncol , vol.26 , Issue.32 , pp. 5147-5150
    • Press, O.W.1
  • 7
    • 77954102491 scopus 로고    scopus 로고
    • Radioimmunotherapy for the treatment of non-Hodgkin lymphoma: Current status and future applications
    • Ahmed S, Winter JN, Gordon LI, Evens AM. Radioimmunotherapy for the treatment of non-Hodgkin lymphoma: current status and future applications. Leuk Lymphoma. 2010; 51(7):1163-77.
    • (2010) Leuk Lymphoma , vol.51 , Issue.7 , pp. 1163-1177
    • Ahmed, S.1    Winter, J.N.2    Gordon, L.I.3    Evens, A.M.4
  • 9
    • 84864504946 scopus 로고    scopus 로고
    • Radioimmunotherapy for B-cell non-hodgkin lymphomas
    • Tomblyn M. Radioimmunotherapy for B-cell non-hodgkin lymphomas. Cancer Control. 2012;19(3):196-203.
    • (2012) Cancer Control , vol.19 , Issue.3 , pp. 196-203
    • Tomblyn, M.1
  • 11
    • 4143137116 scopus 로고    scopus 로고
    • Differential expression of CD22 in indolent and aggressive non-Hodgkin’s lymphoma (NHL): Implications for targeted therapy
    • Cessano A, Gayko, U, Braman C, Kapushoc H, Fields SZ, Perkins SL. Differential expression of CD22 in indolent and aggressive non-Hodgkin’s lymphoma (NHL): implications for targeted therapy. Blood. 2002;100 (Suppl):350a.
    • (2002) Blood , vol.100 , pp. 350a
    • Cessano, A.1    Gayko, U.2    Braman, C.3    Kapushoc, H.4    Fields, S.Z.5    Perkins, S.L.6
  • 12
    • 33750699969 scopus 로고    scopus 로고
    • Epratuzumab in the therapy of oncological and immunological diseases
    • Goldenberg DM. Epratuzumab in the therapy of oncological and immunological diseases. Expert Rev Anticancer Ther. 2006;6 (10):1341-53.
    • (2006) Expert Rev Anticancer Ther , vol.6 , Issue.10 , pp. 1341-1353
    • Goldenberg, D.M.1
  • 13
    • 0042413843 scopus 로고    scopus 로고
    • Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lym-phoma
    • Leonard JP, Coleman M, Ketas JC, Chadburn A, Ely S, Furman RR, et al. Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lym-phoma. J Clin Oncol. 2003;21(16):3051-9.
    • (2003) J Clin Oncol , vol.21 , Issue.16 , pp. 3051-3059
    • Leonard, J.P.1    Coleman, M.2    Ketas, J.C.3    Chadburn, A.4    Ely, S.5    Furman, R.R.6
  • 14
    • 4143123338 scopus 로고    scopus 로고
    • Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lym-phoma: Phase I/II clinical trial results
    • Leonard JP, Coleman M, Ketas JC, Chadburn A, Furman R, Schuster MW, et al. Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lym-phoma: phase I/II clinical trial results. Clin Cancer Res. 2004;10(16):5327-34.
    • (2004) Clin Cancer Res , vol.10 , Issue.16 , pp. 5327-5334
    • Leonard, J.P.1    Coleman, M.2    Ketas, J.C.3    Chadburn, A.4    Furman, R.5    Schuster, M.W.6
  • 15
    • 0028349727 scopus 로고
    • Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2
    • Shih LB, Lu HH, Xuan H, Goldenberg DM. Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2. Int J Cancer. 1994;56(4):538-45.
    • (1994) Int J Cancer , vol.56 , Issue.4 , pp. 538-545
    • Shih, L.B.1    Lu, H.H.2    Xuan, H.3    Goldenberg, D.M.4
  • 16
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from ritux-imab
    • Carnahan J, Stein R, Qu Z, Hess K, Cesano A, Hansen HJ, et al. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from ritux-imab. Mol Immunol. 2007;44(6):1331-41.
    • (2007) Mol Immunol , vol.44 , Issue.6 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3    Hess, K.4    Cesano, A.5    Hansen, H.J.6
  • 17
    • 8544267259 scopus 로고    scopus 로고
    • Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22
    • Sharkey RM, Behr TM, Mattes MJ, Stein R, Griffiths GL, Shih LB, et al. Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22. Cancer Immunol Immunother. 1997;44(3):179-88.
    • (1997) Cancer Immunol Immunother , vol.44 , Issue.3 , pp. 179-188
    • Sharkey, R.M.1    Behr, T.M.2    Mattes, M.J.3    Stein, R.4    Griffiths, G.L.5    Shih, L.B.6
  • 18
    • 0037207880 scopus 로고    scopus 로고
    • Goldenberg DM. 90Y-DOTA-hLL2: An agent for radioimmunotherapy of non-Hodgkin's lymphoma
    • Griffiths GL, Govindan SV, Sharkey RM, Fisher DR, Goldenberg DM. 90Y-DOTA-hLL2: an agent for radioimmunotherapy of non-Hodgkin's lymphoma. J Nucl Med. 2003;44(1):77-84.
    • (2003) J Nucl Med , vol.44 , Issue.1 , pp. 77-84
    • Griffiths, G.L.1    Govindan, S.V.2    Sharkey, R.M.3    Fisher, D.R.4
  • 19
    • 1342307630 scopus 로고    scopus 로고
    • Radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-DOTA humanized anti-CD22 IgG (90Y-epratuzumab): Do tumor targeting and dosimetry predict therapeutic response?
    • Sharkey RM, Brenner A, Burton J, Hajjar G, Toder SP, Alavi A, et al. Radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-DOTA humanized anti-CD22 IgG (90Y-epratuzumab): do tumor targeting and dosimetry predict therapeutic response? J Nucl Med. 2003;44 (12):2000-18.
    • (2003) J Nucl Med , vol.44 , Issue.12 , pp. 2000-2018
    • Sharkey, R.M.1    Brenner, A.2    Burton, J.3    Hajjar, G.4    Toder, S.P.5    Alavi, A.6
  • 20
    • 22344437047 scopus 로고    scopus 로고
    • Dose-fractionated radioimmunotherapy in non-Hodgkin's lymphoma using DOTA-conjugated, 90Y-radiolabeled, humanized anti-CD22 monoclonal antibody, epratuzumab
    • Lindén O, Hindorf C, Cavallin-Ståhl E, Wegener WA, Goldenberg DM, Horne H, et al. Dose-fractionated radioimmunotherapy in non-Hodgkin's lymphoma using DOTA-conjugated, 90Y-radiolabeled, humanized anti-CD22 monoclonal antibody, epratuzumab. Clin Cancer Res. 2005;11(14): 5215-22.
    • (2005) Clin Cancer Res , vol.11 , Issue.14 , pp. 5215-5222
    • Lindén, O.1    Hindorf, C.2    Cavallin-Ståhl, E.3    Wegener, W.A.4    Goldenberg, D.M.5    Horne, H.6
  • 21
    • 0037083345 scopus 로고    scopus 로고
    • Rationales, evidence, and design considerations for fractionated radioimmunotherapy
    • DeNardo GL, Schlom J, Buchsbaum DJ, Meredith RF, O'Donoghue JA, Sgouros G, et al. Rationales, evidence, and design considerations for fractionated radioimmunotherapy. Cancer. 2002;94(4 Suppl):1332-48.
    • (2002) Cancer , vol.94 , Issue.4 , pp. 1332-1348
    • Denardo, G.L.1    Schlom, J.2    Buchsbaum, D.J.3    Meredith, R.F.4    O'donoghue, J.A.5    Sgouros, G.6
  • 22
    • 77957272703 scopus 로고    scopus 로고
    • High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: Results of a multicenter, phase I/II study in non-Hodgkin's lymphoma
    • Morschhauser F, Kraeber-Bodéré F, Wegener WA, Harousseau JL, Petillon MO, Huglo D, et al. High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: results of a multicenter, phase I/II study in non-Hodgkin's lymphoma. J Clin Oncol. 2010;28(23):3709-16.
    • (2010) J Clin Oncol , vol.28 , Issue.23 , pp. 3709-3716
    • Morschhauser, F.1    Kraeber-Bodéré, F.2    Wegener, W.A.3    Harousseau, J.L.4    Petillon, M.O.5    Huglo, D.6
  • 24
    • 0027484445 scopus 로고
    • Radiolabeledantibody therapy of B-cell lymphoma with autologous bone marrow support
    • Press OW, Eary JF, Appelbaum FR, Martin PJ, Badger CC, Nelp WB, et al. Radiolabeledantibody therapy of B-cell lymphoma with autologous bone marrow support. N Engl J Med. 1993;329(17):1219-24.
    • (1993) N Engl J Med , vol.329 , Issue.17 , pp. 1219-1224
    • Press, O.W.1    Eary, J.F.2    Appelbaum, F.R.3    Martin, P.J.4    Badger, C.C.5    Nelp, W.B.6
  • 25
    • 9044254117 scopus 로고    scopus 로고
    • Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma
    • Knox SJ, Goris ML, Trisler K, Negrin R, Davis T, Liles TM, et al. Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. Clin Cancer Res. 1996;2(3):457-70.
    • (1996) Clin Cancer Res , vol.2 , Issue.3 , pp. 457-470
    • Knox, S.J.1    Goris, M.L.2    Trisler, K.3    Negrin, R.4    Davis, T.5    Liles, T.M.6
  • 26
    • 61849136656 scopus 로고    scopus 로고
    • Phase ½ study of fractionated (131)I-rituximab in low-grade B-cell lymphoma: The effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapy
    • Illidge TM, Bayne M, Brown NS, Chilton S, Cragg MS, Glennie MJ, et al. Phase ½ study of fractionated (131)I-rituximab in low-grade B-cell lymphoma: the effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapy. Blood. 2009;113(7):1412-21.
    • (2009) Blood , vol.113 , Issue.7 , pp. 1412-1421
    • Illidge, T.M.1    Bayne, M.2    Brown, N.S.3    Chilton, S.4    Cragg, M.S.5    Glennie, M.J.6
  • 27
    • 50949103161 scopus 로고    scopus 로고
    • Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45 Ab
    • Gopal AK, Press OW, Wilbur SM, Maloney DG, Pagel JM. Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45 Ab. Blood. 2008;112(3):830-5.
    • (2008) Blood , vol.112 , Issue.3 , pp. 830-835
    • Gopal, A.K.1    Press, O.W.2    Wilbur, S.M.3    Maloney, D.G.4    Pagel, J.M.5
  • 28
    • 65449177689 scopus 로고    scopus 로고
    • A re-examination of radioimmunotherapy in the treatment of non-Hodgkin lymphoma: Prospects for dual-targeted antibody/ radioantibody therapy
    • Sharkey RM, Press OW, Goldenberg DM. A re-examination of radioimmunotherapy in the treatment of non-Hodgkin lymphoma: prospects for dual-targeted antibody/ radioantibody therapy. Blood. 2009;113 (17):3891-5.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3891-3895
    • Sharkey, R.M.1    Press, O.W.2    Goldenberg, D.M.3
  • 29
    • 60849089338 scopus 로고    scopus 로고
    • Properties and structure-function relationship of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
    • Goldenberg DM, Rossi EA, Stein R, Cardillo TM, Czuczman S, Hernandez-Ilizaliturri FJ. Properties and structure-function relationship of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood. 2009;113(5):1062-70.
    • (2009) Blood , vol.113 , Issue.5 , pp. 1062-1070
    • Goldenberg, D.M.1    Rossi, E.A.2    Stein, R.3    Cardillo, T.M.4    Czuczman, S.5    Hernandez-Ilizaliturri, F.J.6
  • 30
    • 77951829072 scopus 로고    scopus 로고
    • Veltuzumab (humanized anti-CD20 monoclonal antibody): Characterization, current clinical results, and future prospects
    • Goldenberg DM, Morschhauser F, Wegener WA. Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects. Leuk Lymphoma. 2010;51(5):747-55.
    • (2010) Leuk Lymphoma , vol.51 , Issue.5 , pp. 747-755
    • Goldenberg, D.M.1    Morschhauser, F.2    Wegener, W.A.3
  • 31
    • 70249106098 scopus 로고    scopus 로고
    • Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results
    • Morschhauser F, Leonard JP, Fayad L, Coiffier B, Petillon MO, Coleman M, et al. Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol. 2009;27(20):3346-53.
    • (2009) J Clin Oncol , vol.27 , Issue.20 , pp. 3346-3353
    • Morschhauser, F.1    Leonard, J.P.2    Fayad, L.3    Coiffier, B.4    Petillon, M.O.5    Coleman, M.6
  • 32
    • 79953883456 scopus 로고    scopus 로고
    • Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma
    • Negrea GO, Elstrom R, Allen SL, Rai KR, Abbasi RM, Farber CM, et al. Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma. Haematologica. 2011;96(4):567-73.
    • (2011) Haematologica , vol.96 , Issue.4 , pp. 567-573
    • Negrea, G.O.1    Elstrom, R.2    Allen, S.L.3    Rai, K.R.4    Abbasi, R.M.5    Farber, C.M.6
  • 33
    • 58149161750 scopus 로고    scopus 로고
    • Therapy of advanced B-lymphoma xenografts with a combination of 90Y-anti-CD22 IgG (epratuzumab) and unlabeled anti-CD20 IgG (veltuzumab)
    • Mattes MJ, Sharkey RM, Karacay H, Czuczman MS, Goldenberg DM. Therapy of advanced B-lymphoma xenografts with a combination of 90Y-anti-CD22 IgG (epratuzumab) and unlabeled anti-CD20 IgG (veltuzumab). Clin Cancer Res. 2008;14 (19):6154-60.
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 6154-6160
    • Mattes, M.J.1    Sharkey, R.M.2    Karacay, H.3    Czuczman, M.S.4    Goldenberg, D.M.5
  • 34
    • 0001757904 scopus 로고    scopus 로고
    • Classification of non-Hodgkin’s lymphomas
    • Knowles DM, ed., 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins;  001
    • Harris NL, Ferry JA. Classification of non-Hodgkin’s lymphomas. In: Knowles DM, ed. Neoplastic Hematopathology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins;  001. p. 691-753.
    • Neoplastic Hematopathology , pp. 691-753
    • Harris, N.L.1    Ferry, J.A.2
  • 35
    • 0027444652 scopus 로고
    • A predictive model for aggressive non-Hodgkin's lymphoma
    • The International Non-Hodgkin's Lymphoma Prognostic Factors Project
    • The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med. 1993; 329(14):987-94.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 987-994
  • 38
    • 0027537029 scopus 로고
    • Bone marrow dosimetry for radioimmunotherapy: Theoretical considerations
    • Sgouros G. Bone marrow dosimetry for radioimmunotherapy: theoretical considerations. J Nucl Med. 1993;34(4):689-94.
    • (1993) J Nucl Med , vol.34 , Issue.4 , pp. 689-694
    • Sgouros, G.1
  • 39
    • 84908398215 scopus 로고    scopus 로고
    • Consolidation anti-CD22 fractionated radioimmunotherapy (RIT) with 90Y-epratuzumab tetraxetan following R-CHOP in elderly diffuse large B-cell lymphoma (DLBCL) patients
    • Kraeber-Bodéré F, Pallardy A, Soubeyran P, Bodet-Milin C, Garin E, Vuillez J-P, et al. Consolidation anti-CD22 fractionated radioimmunotherapy (RIT) with 90Y-epratuzumab tetraxetan following R-CHOP in elderly diffuse large B-cell lymphoma (DLBCL) patients. J Nucl Med. 2013;54(2 suppl):179.
    • (2013) J Nucl Med , vol.54 , Issue.2 , pp. 179
    • Kraeber-Bodéré, F.1    Pallardy, A.2    Soubeyran, P.3    Bodet-Milin, C.4    Garin, E.5    Vuillez, J.-P.6
  • 40
    • 34347397783 scopus 로고    scopus 로고
    • Efficacy and safety of yttrium-90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem-cell transplantation
    • Morschhauser F, Illidge T, Huglo D, Martinelli G, Paganelli G, Zinzani PL, et al. Efficacy and safety of yttrium-90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem-cell transplantation. Blood. 2007;110(1):54-8.
    • (2007) Blood , vol.110 , Issue.1 , pp. 54-58
    • Morschhauser, F.1    Illidge, T.2    Huglo, D.3    Martinelli, G.4    Paganelli, G.5    Zinzani, P.L.6
  • 41
    • 70449727887 scopus 로고    scopus 로고
    • Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma
    • Wang M, Oki Y, Pro B, Romaguera JE, Rodriguez MA, Samaniego F, et al. Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009; 27(31):5213-8.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5213-5218
    • Wang, M.1    Oki, Y.2    Pro, B.3    Romaguera, J.E.4    Rodriguez, M.A.5    Samaniego, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.