The consequences of a lab escape of a potential pandemic pathogen

Frontiers in Public Health

Volumn 2, Issue AUG, 2014, Pages

  Klotz, Lynn C ^a   Sylvester, Edward J ^b  

^a Center for Arms Control and Non Proliferation   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Gain of function; H5N1; H7N9; Lab acquired infection; Potential pandemic pathogen

Indexed keywords

EID: 84908407500     PISSN: None     EISSN: 22962565     Source Type: Journal    
DOI: 10.3389/fpubh.2014.00116     Document Type: Article

References (22)

1. Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, et al. Gain- of-function experiments on H7N9. Science (2013) 341:612-3. doi:10.1126/science.1243325
2. Fouchier RA, Kawaoka Y, Cardona C, Compans RW, Fouchier RA, García-Sastre A, et al. Avian flu: gain-of-function experiments on H7N9. Nature (2013) 500:150-1. doi:10.1038/500150a
3. Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, et al. Airborne transmis- sion of influenza A/H5N1 virus between ferrets. Science (2012) 336:1534-41. doi:10.1126/science. 1213362
4. Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature (2012) 486:420-8. doi:10.1038/nature10831
5. Zhang Y, Zhang Q, Kong H, Jiang Y, Gao Y, Deng G, et al. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet. Science (2013) 340:1459-63. doi:10.1126/science.1229455
6. Sutton TC, Finch C, Shao H, Angel M, Chen H, Capua I, et al. Airborne transmission of highly pathogenic H7N1 influenza in ferrets. J Virol (2014) 88:6623-35. doi:10.1128/JVI.02765-13
7. Klotz LC. The Human Fatality and Economic Burden of a Man-made Influenza Pandemic: A Risk Assessment. The Center for Arms Control & Non- Proliferation (2014). Available from: http://arms controlcenter.org/The_Human_Fatality_Burden_ of_Gain_of_Function_Flu_Research_v1-5-14.pdf or http://bio-security.org/wp-content/uploads/2014/01/Human-Fatality-Economic-Burden-of- Gain-of-Function-Flu-Research-v1-5-14.pdf
8. Klotz L, Sylvester S. Opinion: The Fatality Burden. (2013). Available from: http://www.the- scientist.com/articles.view/articleNo/38651/title/Opinion-The-Fatality-Burden/
9. Merler S, Ajelli M, Fumanelli L, Vespignani A. Con-taining the accidental lab escape of potential pan- demic influenza viruses. BMCMed (2013) 11:252. doi:10.1186/1741-7015-11-252
10. Lipsitch M, Cohen T, Cooper B, Robins JM, Ma S, James L, et al. Transmission dynamics and control of severe acute respiratory syndrome. Science (2003) 300:1966-70. doi:10.1126/science. 1086616
11. Henkel RD, Miller T, Weyant RS. Monitoring select agent theft, loss and release reports in the United States 2004-2010. Appl Biosafety (2012) 17:171-80. Available from: http://www.absa.org/abj/abj/121704FAHenkel.pdf
12. Specific Incidences of Lab-Acquired SARS-CoV Infections. Centers forDisease Control and Preven- tion (2005). Available from: http://www.cdc.gov/sars/lab/biosafety.html
13. Klotz LC. Sharpening Our Intuition on Man-made Pandemics. Breeding BioSecurity Blog (2012). Available from: http://bio-security.org/wp- content/uploads/2012/05/SharpeningOurIntuition 0515.pdf
14. Evaluation of the Updated Site-Specific Risk Assess- ment for the National Bio- and Agro-Defense Facil- ity inManhattan, Kansas. The National Academies Press (2012). Available from: http://www.nap.edu/catalog.php?record_id=13418
15. Report on the Potential Exposure to Anthrax. Cen- ters for Disease Control and Prevention (2014). Available from: http://www.cdc.gov/od/science/integrity/docs/Final_Anthrax_Report.pdf
16. Review of CDC Anthrax Lab Incident. Energy & Commerce Committee, United States House of Rep- resentatives. (2014). Available from: http://energy commerce.house.gov/hearing/review-cdc-anthrax -lab-incident#video
17. Wain-Hobson S. Response to Letter by the Euro- pean Society for Virology on "Gain-of-Function" Influenza Research. The Foundation for Vaccine Research (2013). Available from: http://www. nature.com/polopoly_fs/7.14586!/file/vaccine%20 foundation%20letter.pdf
18. Circulating Avian Influenza Viruses Closely Related to the 1918 Virus Have Pandemic Potential. Euro- pean Centre for Disease Prevention and Control. (2014). Available from: http://ecdc.europa.eu/en/activities/sciadvice/_layouts/forms/Review_Disp Form.aspx?List=a3216f4c-f040-4f51-9f77-a96046 dbfd72&ID=765
19. Cambridge Working Group Consensus Statement on the Creation of Potential Pandemic Pathogens (PPPs). Available from: http://www.cambridgeworkinggroup.org/
20. Furmanski M. Lab Escapes and "Self-fulfilling prophecy" Epidemics. Center for Arms Control and Nonproliferation (2014). Available from: http://armscontrolcenter.org/Escaped_Viruses-final_2-17-14.pdf
21. Furmanski M. Threatened pandemics and lab escapes: self-fulfilling prophecies. Bull Atom Sci (2014). Available from: http://thebulletin.org/threatened-pandemics-and-laboratory-escapes- self-fulfilling-prophecies7016
22. Klotz LC, Sylvester EJ. The unacceptable risks of a man-made pandemic. Bull Atom Sci (2012). Available from: http://thebulletin.org/unacceptable-risks-man-made-pandemic