Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: Synthesis, anti-invasive and anti-angiogenic properties

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 88-97

  Wang, Lihui ^a   Chen, Guoliang ^a   Lu, Xiuhong ^a   Wang, Shuang ^a   Han, Shanghe ^a   Li, Yi ^a   Ping, Guanfang ^a   Jiang, Xiaorui ^a   Li, Huahuan ^a   Yang, Jingyu ^a   Wu, Chunfu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Cancer; Chalcone; Hypoxia inducible factor 1; Invasion

Indexed keywords

1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) 3 (2 HYDROXY 3 METHOXYPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) 3 (2 METHOXYPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) 3 (3 METHOXYPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) 3 (3TRIFLUOROMETHYLPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMEN 6 YL) 3 (3 HYDROXY 4 METHOXYPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMEN 6 YL) 3 (4 TRIFLUOROMETHYLPHENYL) PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMEN 6 YL) 3 NAPHTHALEN 2 YL PROPENONE; 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMEN 6 YL) 3 PYRIDIN 3 YL PROPENONE; 1 (8 HYDROXY 2,2 DIMETHYL 2H CHROMEN 7 YL) ETHANONE; 1 [4 (1,1 DIMETHYL PROP 2 YNYLOXY) 2 HYDROXY PHENYL] ETHANONE; 3 (2,3 DIMETHOXYPHENYL) 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) PROPENONE; 3 (3 FLUORO PHENYL) 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) PROPENONE; 3 (4 FLUORO PHENYL) 1 (5 HYDROXY 2,2 DIMETHYL 2H CHROMAN 6 YL) PROPENONE; 3 CHLORO 3 METHYL BUT 1 YNE; ANGIOGENESIS INHIBITOR; CD31 ANTIGEN; CHALCONE DERIVATIVE; GELATINASE A; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT; CHALCONE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ACUTE TOXICITY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANTI INVASIVE PROPERTY; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL SURFACE; CELL VIABILITY; CHLORINATION; CONTROLLED STUDY; DEGENERATION; DOWN REGULATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ELECTROPHILICITY; EXTRACELLULAR MATRIX; HEART DISEASE; HUMAN; HUMAN CELL; HYPOXIA; IN VIVO STUDY; MALE; METASTASIS; MOUSE; MTT ASSAY; NONHUMAN; NUCLEOPHILICITY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR GROWTH; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL MOTION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL MOVEMENT; CELL PROLIFERATION; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84908405890     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.10.036     Document Type: Article

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