Nanoparticles based on naturally-occurring biopolymers as versatile delivery platforms for delicate bioactive molecules: An application for ocular gene silencing

International Journal of Pharmaceutics

Volumn 477, Issue 1, 2014, Pages 12-20

  Parraga, Jenny E ^a   Zorzi, Giovanni K ^a,d   Diebold, Yolanda ^c   Seijo, Begoña ^a,b   Sanchez, Alejandro ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Santiago University Clinical Hospital   (Spain)

^c UNIVERSITY OF VALLADOLID   (Spain)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cationized gelatine; Nanoparticles; Polyanionic biopolymers; siRNAGene therapy; Spermine

Indexed keywords

CHONDROITIN SULFATE; DEXTRAN SULFATE; GELATIN; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HYALURONIC ACID; NANOPARTICLE; POLYAMINE; POLYSACCHARIDE; POLYSIALIC ACID; SMALL INTERFERING RNA; SPERMINE; BIOPOLYMER;

ARTICLE; CELL VIABILITY ASSAY; CONTROLLED STUDY; EVALUATION STUDY; GENE DELIVERY SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; MOLECULE; NONVIRAL GENE THERAPY; PARTICLE SIZE; ZETA POTENTIAL; ANIMAL; CHEMISTRY; CONJUNCTIVA; CORNEA; METABOLISM; RABBIT;

ANIMALS; BIOPOLYMERS; CONJUNCTIVA; CORNEA; GELATIN; GENE SILENCING; HUMANS; NANOPARTICLES; PARTICLE SIZE; RABBITS; RNA, SMALL INTERFERING; SPERMINE;

EID: 84908396404     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.09.049     Document Type: Article

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