Diversity-oriented synthesis-facilitated medicinal chemistry: Toward the development of novel antimalarial agents

Journal of Medicinal Chemistry

Volumn 57, Issue 20, 2014, Pages 8496-8502

  Comer, Eamon ^a   Beaudoin, Jennifer A ^a   Kato, Nobutaka ^a   Fitzgerald, Mark E ^a   Heidebrecht, Richard W ^a   Lee, Maurice Dupont ^a   Masi, Daniela ^a   Mercier, Marion ^a   Mulrooney, Carol ^a   Muncipinto, Giovanni ^a   Rowley, Ann ^a   Crespo Llado, Keila ^d   Serrano, Adelfa E ^d   Lukens, Amanda K ^a,e   Wiegand, Roger C ^a   Wirth, Dyann F ^a,e   Palmer, Michelle A ^a   Foley, Michael A ^a   Munoz, Benito ^a   Scherer, Christina A ^a   Duvall, Jeremy R ^a   Schreiber, Stuart L ^a,b,c   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; ATOVAQUONE; CHLOROQUINE; ANTIMALARIAL AGENT; ERG1 POTASSIUM CHANNEL; MACROCYCLIC LACTAM; POTASSIUM CHANNEL HERG;

ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIVERSITY ORIENTED SYNTHESIS; DRUG SOLUBILITY; DRUG STABILITY; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RING CLOSING METATHESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SOLUBILITY;

ANTIMALARIALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CHEMISTRY, PHARMACEUTICAL; ETHER-A-GO-GO POTASSIUM CHANNELS; LACTAMS, MACROCYCLIC; PLASMODIUM FALCIPARUM; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908388868     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500994n     Document Type: Article

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