Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice

Brain

Volumn 137, Issue 10, 2014, Pages 2670-2679

  Yonekawa, Takahiro ^a,b   Malicdan, May Christine V ^c   Cho, Anna ^a   Hayashi, Yukiko K ^a,d,e   Nonaka, Ikuya ^a   Mine, Toshiki ^f   Yamamoto, Takeshi ^f   Nishino, Ichizo ^a,b,d   Noguchi, Satoru ^a,d  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^e TOKYO MEDICAL UNIVERSITY   (Japan)

^f Japan Tabacco Inc   (Japan)

Author keywords

Amyloid inclusion; Distal myopathy with rimmed vacuoles (DMRV) hereditary inclusion body myopathy (hIBM); GNE myopathy; Hyposialylation; Sialyllactose

Indexed keywords

6' SIALYLLACTOSE; 6'-SIALYLLACTOSE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); CREATINE KINASE; DRUG DERIVATIVE; HEXOSAMINE; LACTOSE; N ACETYLMANNOSAMINE; N ACETYLNEURAMINIC ACID; N-ACETYLMANNOSAMINE; PEPTIDE FRAGMENT; SIALYLLACTOSE;

AGING; AMYLOID INCLUSION; ANIMAL; ARTICLE; BODY WEIGHT; CELL CULTURE; DISEASE MODEL; DISTAL MYOPATHY; DISTAL MYOPATHY WITH RIMMED VACUOLES (DMRV)/HEREDITARY INCLUSION BODY MYOPATHY (HIBM); DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; GNE MYOPATHY; HYPOSIALYLATION; METABOLISM; MOUSE; MUSCLE CONTRACTION; MUTATION; MYOBLAST; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; SKELETAL MUSCLE;

AMYLOID INCLUSION; DISTAL MYOPATHY WITH RIMMED VACUOLES (DMRV)/HEREDITARY INCLUSION BODY MYOPATHY (HIBM); GNE MYOPATHY; HYPOSIALYLATION; SIALYLLACTOSE;

AGING; AMYLOID BETA-PEPTIDES; ANIMALS; BODY WEIGHT; CELLS, CULTURED; CREATINE KINASE; DISEASE MODELS, ANIMAL; DISTAL MYOPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEXOSAMINES; LACTOSE; MICE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUTATION; MYOBLASTS; N-ACETYLNEURAMINIC ACID; PEPTIDE FRAGMENTS; PHENOTYPE;

EID: 84908388654     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu210     Document Type: Article

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