A new potassium ion current induced by stimulation of M2 cholinoreceptors in fish atrial myocytes

Journal of Experimental Biology

Volumn 217, Issue 10, 2014, Pages 1745-1751

  Abramochkin, Denis V ^a,b   Tapilina, Svetlana V ^a   Vornanen, Matti ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Acetylcholine; Atrial myocytes; Fish heart; IKACh; Ionic currents; Muscarinic receptors

Indexed keywords

CARASSIUS; CARASSIUS CARASSIUS; ONCORHYNCHUS MYKISS; TELEOSTEI;

2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; ATROPINE; CARBACHOL; CHOLINERGIC RECEPTOR STIMULATING AGENT; FISH PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; POTASSIUM; SODIUM CALCIUM EXCHANGE PROTEIN; THIOUREA;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CARP; CYTOLOGY; DRUG EFFECTS; HEART ATRIUM; HEART MUSCLE CELL; METABOLISM; PATCH CLAMP TECHNIQUE; RAINBOW TROUT;

ANIMALS; ATROPINE; CARBACHOL; CARPS; CHOLINERGIC AGONISTS; FISH PROTEINS; HEART ATRIA; MUSCARINIC ANTAGONISTS; MYOCYTES, CARDIAC; ONCORHYNCHUS MYKISS; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTOR, MUSCARINIC M2; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 84908382124     PISSN: 00220949     EISSN: 14779145     Source Type: Journal    
DOI: 10.1242/jeb.098509     Document Type: Article

References (25)

1. Abramochkin, D. V., Kuzmin, V. S., Sukhova, G. S. and Rosenshtraukh, L. V. (2010).Cholinergic modulation of activation sequence in the atrial myocardium of non-mammalian vertebrates. Comp. Biochem. Physiol. 155A, 231-236.
2. Abramochkin, D. V., Tapilina, S. V., Sukhova, G. S., Nikolsky, E. E. and Nu rullin, L. F. (2012). Functional M3 cholinoreceptors are present in pacemaker and working myocardium of murine heart. Pflugers Arch. 463, 523-529.
3. Boyett, M. R., Kodama, I., Honjo, H., Arai, A., Suzuki, R. and Toyama, J. (1995). Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node. Cardiovasc. Res. 29, 867-878.
4. Brodde, O. E. and Michel, M. C. (1999). Adrenergic and mus carinic receptors in the human heart. Pharmacol. Rev. 51, 651-690.
5. Dhein, S., van Koppen, C. J. and Brodde, O. E. (2001). Muscarinic receptors in the mammalian heart. Pharmacol. Res. 44, 161-182.
6. Doods, H. N., Mathy, M. J., Davidesko, D., van Charldorp, K. J., de Jonge, A. and van Zwieten, P. A. (1987). Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors. J. Pharmacol. Exp. Ther. 242, 257-262.
7. Giachetti, A., Micheletti, R. and Montagna, E. (1986). Cardioselective profile of AFDX 116, a muscarine M2 receptor antagonist. Life Sci. 38, 1663-1672.
8. Hartzell, H. C. (1988). Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems. Prog. Biophys. Mol. Biol. 52, 165-247.
9. Hassinen, M., Paajanen, V. and Vornanen, M. (2008). A novel inwardly rectifying K+ channel, Kir2.5, is upregulated under chronic cold stress in fish cardiac myocytes. J. Exp. Biol. 211, 2162-2171.
10. Hellgren, I., Mustafa, A., Riazi, M., Suliman, I., Sylvén, C. and Adem, A. (2000). Muscarinic M3 receptor subtype gene expression in the human heart. Cell. Mol. Life Sci. 57, 175-180.
11. Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I. and Kurachi, Y. (2010). Inwardly rectifying potassium channels: their structure, function , and physiological roles. Physiol. Rev. 90, 291-366.
12. Jaillon, O., Aury, J.-M., Brunet, F., Petit, J.-L., Stange-Thomann, N., Mauceli, E., Bouneau, L., Fischer, C., Ozouf-Costaz, C., Bernot, A. et al. (2004). Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature 431, 946-957.
13. Kakehata, S., Nakagawa, T., Takasaka, T. and Akaike, N. (1993). Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea. J. Physiol. 463, 227-244.
14. Kitazawa, T., Asakawa, K., Nakamura, T., Teraoka, H., Unno, T., Komori, S., Yamada, M. and Wess, J. (2009). M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. J. Pharmacol. Exp. Ther. 330, 487-493.
15. Langhein rich, U., Vacun, G. and Wagner, T. (2003). Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicol. Appl. Pharmacol. 193, 370-382.
16. Levy, M. N. (1971). Sympathetic-parasympathetic interactions in the heart. Circ. Res. 29, 437-445.
17. Milan, D. J., Peterson, T. A., Ruskin, J. N., Peterson, R. T. and MacRae, C. A. (2003). Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107, 1355-1358.
18. Navarro-Polanco R. A.,Aréchiga-Figueroa I. A.,Salazar-Fajardo P. D.,Benavides-Haro D. E.,Rodríguez-Elí as, J. C.,Sachse, F. B.,Tristani-Firouzi, M.,Sánchez-Chapula, J. A.,Moreno-Galindo, EG. 2013 Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K+ current (IKACh) by choline in feline atrial myocytes. J. Physiol. 591, 4273-4286.
19. Pönicke, K., Heinroth-Hoffmann, I. and Brodde, O.-E. (2003). Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats. Br. J. Pharmacol. 138, 156-160.
20. Sanders, L., Rakovic, S., Lowe, M., Mattick, P. A. and Terrar, D. A. (2006). Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. J. Physiol. 571, 639-649.
21. Vornanen, M. (1997). Sarcolemmal Ca influx through L-type Ca channels in ventricular myocytes of a teleost fish. Am. J. Physiol. 272, R1432-R1440.
22. Vornanen, M. and Tuomennoro, J. (1999). Effects of acute anoxia on heart function in crucian carp: importance of cholinergic and purinergic control. Am. J. Physiol. 277, R465-R475.
23. Wang, H., Shi, H., Lu, Y., Yang, B. and Wang, Z. (1999). Pilocarpine modulates the cellular electrical properties of mammalian hearts by activ ating a cardiac M3 receptor and a K+ current. Br. J. Pharmacol. 126, 1725-1734.
24. Wang, H., Lu, Y. and Wang, Z. (2007). Function of cardiac M3 receptors. Auton. Autacoid Pharmacol. 27, 1-11.
25. Xu, Y., Tuteja, D., Zhang, Z., Xu, D., Zhang, Y., Rodriguez, J., Nie, L., Tuxson, H. R., Young, J. N., Glatter, K. A. et al. (2003). Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts. J. Biol. Chem. 278, 49085-49094.