In vitro and in vivo antidiabetic and antiglycation properties of apium graveolens in type 1 and 2 diabetic rats

International Journal of Pharmacology

Volumn 10, Issue 7, 2014, Pages 368-379

  Gutierrez, Rosa Martha Perez ^a   Juarez, Vicente Aguiniga ^a   Sauceda, Jahel Valdes ^a   Sosa, Irasema Anaya ^b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Anti diabetic; Apium graveolens; Hepatoprotective; Insulin resistance; Lipid peroxidation; Renalprotective

Indexed keywords

ALKALINE PHOSPHATASE; AMINOGUANIDINE; BILIRUBIN; BOVINE SERUM ALBUMIN; CELERY EXTRACT; GLYCOSYLATED HEMOGLOBIN; METHYLGLYOXAL; PLANT EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; BLOOD ANALYSIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOD INTAKE; GLYCATION; GLYCOGEN ANALYSIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TOLERANCE TEST; LIPID PEROXIDATION; MALE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; RAT;

EID: 84908375936     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2014.368.379     Document Type: Article

References (32)

1. Ay bar, M.J., A.N. Sanchez Riera, A. Grau and S. S. Sanchez, 2001. Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats. J. Ethnopharmacol., 74: 125-132.
2. Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254.
3. Brownlee, M., 1995. The pathological implications of protein glycation. Clin. Invest. Med., 18: 275-281.
4. Fraga, C.G., B.E. Leibovitz and A.L. Tappel, 1988. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: Characterization and comparison with homogenates and microsomes. Free Radical Biol. Med., 4: 155-161.
5. Holst, J.J., 2007. The physiology of glucagon-like peptide Phys. Rev., 87: 1409-1439.
6. Hosseinzadeh, H., M. Ramezani and A. Danaei, 2002. Antihyperglycaemic effect and acute toxicity of Securigera securidaca L. seed extracts in mice. Phytother. Res., 16: 745-747.
7. Iyer, D. and U.K. Patil, 2011. Effect of chloroform and aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in rats. J. Complementary Integr. Med., Vol. 8. 10.2202/1553-3840.1529
8. Jelodar, G., M. Maleki and S. Sirus, 2007. Effect of fumitory, celery and lemon on blood glucose and histopathology of pancreas of alloxan diabetic rats. J. Applied Anim. Res., 31: 101-104.
9. Jung, K. and M. Pergande, 1985. Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria. FEBS Lett., 183: 167-169.
10. Kasetti, R.B., M.D. Rajasekhar, V.K. Kondeti, S.S. Fatima and E.G.T. Kumar etal., 2010. Antihyperglycemic and antihyperlipidemic activities of methanol: Water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem. Toxicol., 48: 1078-1084.
11. Khalifah, R.G., J.W. Baynes and B.G. Hudson, 1999. Amadorins: Novel post-Amadori inhibitors of advanced glycation reactions. Biochem. Biophys. Res. Commun, 257: 251-258.
12. Latha, R.C.R. and P. Daisy, 2011. Insulin-secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. in streptozotocin-induced diabetic rats. Chem. Biol. Interact., 189: 112-118.
13. Mandal, S., B. Hazra, R. Sarkar, S. Biswas and N. Mandal, Assessment of the antioxidant and reactive oxygen species scavenging activity of methanolic extract of Caesalpinia crista leaf. Evidence-Based Complementary Alter. Med. 10.1093/ecam/nep072
14. Matkovics, B., M. Kotorman, I.S. Varga, D.Q. Hai and Varga, 1998. Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiologica Hungarica, 85: 29-38.
15. Matsuura, N., T. Aradate, E. Sasaki, H. Kojima and M. Ohara, J. Hasegawa and M. Ubukata, 2002. Screening system for the Maillard reaction inhibitor from natural product extracts. J. Health Sci., 48: 520-526.
16. Momose, T., Y. Yano and K. Ohashi, 1963. Organic analysis. XLIV. A new deproteinizing agent for determination of blood sugar. Chem. Pharm. Bull., 11: 968-972.
17. Nakayama, H., T. Mitsuhashi, S. Kuwajima, S. Aoki, Y. Kuroda, T. Itoh and S. Nakagawa, 1993. Immunochemical detection of advanced glycation end products in lens ciystallins from streptozocin- induced diabetic rat. Diabetes, 42: 345-350.
18. Nikki, K.E., 2001. Free radical in the 1990s from in vitro to in vivo. Free Radical Res., 33: 693-704.
19. Pari, L. and M.A. Satheesh, 2004. Antidiabetic activity of Boerhaavia diffusa L.: Effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91: 109-113.
20. Park, S.E., M.H. Cho, J.K. Lim, J.S. Kim, J.H. Kim, D.Y. Kwon and C.S. Park, 2007. A new colorimetric method for determining the isomerization activity of sucrose isomerase. Biosci. Biotechnol. Biochem., 71: 583-586.
21. Patel, D.K., R. Kumar, S.K. Prasad, K. Sairam and S. Hemalatha, 2011. Anti diabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pacific J. Trop. Biomed., 1: 316-322.
22. Pepato, M.T., R.H. Migliorini, A.L. Goldberg and C. Kettelhut, 1996. Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats. Am. J. Physiol., 271: E340-E347.
23. Pociot, F., J.I. Reimers and H.U. Andersen, 1993. Nicotinamide-biological actions and therapeutic potential in diabetes prevention. Diabetologia, 36: 574-576.
24. Rahbar, S. and J.L. Figarola, 2003. Novel inhibitors of advanced glycation endproducts. Arch. Biochem. Biophys., 419: 63-79.
25. Sharma, M., M.W. Siddique, A.M. Shamim, S. Gyanesh and K.K. Pillai, 2011. Evaluation of anti diabetic and antioxidant effects of seabuckthom (.Hippophaerhamnoides L.) in streptozotocin- nicotinamide induced diabetic rats. Open Conf. Proceed. J., 2: 53-58.
26. Sowbhagya, H.B., 2014. Chemistry, technology and nutraceutical functions of celery (Apium graveolens L.): An overview. Crit. Rev. Food Sci. Nutr., 54: 389-398.
27. Tahara, A., A. Matsuyama-Yokono, R. Nakano, Y. Someya and M. Shibasaki, 2008. Hypoglycaemic effects of antidiabetic drugs in streptozotocin- nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats. Basic Clin. Pharmacol. Toxicol., 103: 560-568.
28. Uchiyama, M. and M. Mihara, 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem., 86: 271-278.
29. Voziyan, P.A., T.O. Metz, J.W. Baynes and B.G. Hudson, 2002. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J. Biol. Chem., 277: 3397-3403.
30. White house, M.W., D.E. Butters, M.L. Clark and K.D. Ranisford, 2001. NSAID gastropathy: Prevention by celeiy seed extracts in disease- stressed rats. Inflammopharamacology, 9: 201-209.
31. Zhou, J.Y., S.W. Zhou, S.Y. Zeng, J.Y. Zhou, M.J. Jiang and Y. He, 2012. Hypoglycemic and hypolipidemic effects of ethanolic extract of Mirabilis jalapa L. root on normal and diabetic mice. Evidence-Based Complementaiy Altern. Med., 10.1155/2012/257374.
32. Zhou, K., F. Zhao, Z. Liu, Y. Zhuang, L. Chen and F. Qiu, 2009. Triterpenoids and flavonoids from celeiy (Apium graveolens). J. Nat. Prod., 72: 1563-1567.