Remotely activated Mechanotransduction via magnetic nanoparticles promotes mineralization synergistically with bone morphogenetic protein 2: Applications for Injectable cell therapy

Stem Cells Translational Medicine

Volumn 3, Issue 11, 2014, Pages 1363-1375

  Henstock, James R ^a   Rotherham, Michael ^a   Rashidi, Hassan ^b   Shakesheff, Kevin M ^b   El Haj, Alicia J ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Bone marrow stromal cells; Cellular therapy; Clinical translation; Differentiation; Mesenchymal stem cells; Tissue regeneration; Transduction

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; MAGNETIC NANOPARTICLE; POTASSIUM CHANNEL; BMP2 PROTEIN, HUMAN; NANOPARTICLE; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; BIOREACTOR; BONE DENSITY; BONE MINERALIZATION; CELL THERAPY; CHICK; CONTROLLED STUDY; DRUG POTENTIATION; ENCAPSULATION; ENCHONDRAL OSSIFICATION; EPIPHYSIS; FEMUR; HISTOLOGY; HUMAN; HUMAN CELL; HYDROGEL; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MICROINJECTION; NONHUMAN; STEM CELL CULTURE; TISSUE ENGINEERING; ANIMAL; CHEMISTRY; CHICK EMBRYO; CHICKEN; DRUG EFFECTS; MAGNETIC FIELD; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; XENOGRAFT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CHICK EMBRYO; CHICKENS; FEMUR; HETEROGRAFTS; HUMANS; MAGNETIC FIELDS; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; NANOPARTICLES; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84908374740     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0017     Document Type: Article

References (34)

1. Simon JA, Ricci JL, Di Cesare PE. Bioresorbable fracture fixation in orthopedics: A comprehensive review. Part I. Basic science and preclinical studies. Am J Orthop 1997;26:665-671.
2. Kim IS, Song YM, Cho TH et al. Synergistic action of static stretching and BMP-2 stimulation in the osteoblast differentiation of C2C12 myoblasts. J Biomech 2009;42:2721-2727.
3. Kopf J, Petersen A, Duda GN et al. BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway. BMC Biol 2012;10:37.
4. Griffin XL, Costello I, Costa ML. The role of low intensity pulsed ultrasound therapy in the management of acute fractures: A systematic review. J Trauma 2008;65:1446-1452.
5. Frias C, Reis J, Capela e Silva F et al. Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. J Biomech 2010; 43:1061-1066.
6. Walker NA, Denegar CR, Preische J. Lowintensity pulsed ultrasound and pulsed electromagnetic fieldin the treatmentof tibial fractures: A systematic review. J Athl Train 2007;42:530-535.
7. Wimpenny I, Markides H, El Haj AJ. Orthopaedic applications of nanoparticlebased stem cell therapies. Stem Cell Res Ther 2012;3:13.
8. Kanczler JM, Sura HS, Magnay J et al. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng Part A 2010;16:3241-3250.
9. Hughes S, Dobson J, El Haj AJ. Magnetic targeting of mechanosensors in bone cells for tissue engineering applications. J Biomech 2007; 40(suppl 1):S96-S104.
10. Hughes S, Magnay J, Foreman M et al. Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. J Cell Physiol 2006;206:738-748.
11. Hughes S, McBain S, Dobson J et al. Selective activation of mechanosensitive ion channels usingmagneticparticles. JRSoc Interface 2008;5: 855-863.
12. Cartmell SH, Dobson J, Verschueren SB et al. Development of magnetic particle techniques for long-termculture of bone cells with intermittent mechanical activation. IEEE Trans Nanobioscience 2002;1:92-97.
13. Henstock JR, Rotherham M, Rose JB et al. Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro. Bone 2013;53:468-477.
14. Kanczler JM, Smith EL, Roberts CA et al. A novel approach for studying the temporal modulation of embryonic skeletal development using organotypic bone cultures and microcomputed tomography. Tissue Eng Part C Methods 2012;18:747-760.
15. Smith EL, Kanczler JM, Roberts CA et al. Developmental cues for bone formation from parathyroid hormone and parathyroid hormone-related protein in an ex vivo organotypic culture system of embryonic chick femora. Tissue Eng Part C Methods 2012;18:984-994.
16. Hamburger V, Hamilton HL. A series of normal stages in the development of the chick embryo. J Morphol 1951;88:49-92.
17. Barbetta A, Bedini R, Pecci R et al. Role of x-ray microtomography in tissue engineering. Ann Ist Super Sanita 2012;48:10-18.
18. Kirby GTS, White LJ, Rahman CV et al. PLGA-based microparticles for the sustained release of BMP-2. Polymers 2011;3:571-586.
19. Saif J, Schwarz TM, Chau DY et al. Combination of injectable multiple growth factorreleasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization. Arterioscler Thromb Vasc Biol 2010; 30:1897-1904.
20. Kanczler JM, Ginty PJ, White L et al. The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 2010;31: 1242-1250.
21. Nowlan NC, Sharpe J, Roddy KA et al. Mechanobiology of embryonic skeletal development: Insights from animal models. Birth Defects Res C Embryo Today 2010;90:203-213.
22. Mullender M, El Haj AJ, Yang Y et al. Mechanotransduction of bone cells in vitro: Mechanobiology of bone tissue. Med Biol Eng Comput 2004;42:14-21.
23. Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 1995;57: 344-358.
24. Kearney EM, Farrell E, Prendergast PJ et al. Tensile strain as a regulator of mesenchymal stem cell osteogenesis. Ann Biomed Eng 2010;38:1767-1779.
25. Ozcivici E, Luu YK, Adler B et al. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol 2010;6:50-59.
26. Hamill OP, Martinac B. Molecular basis of mechanotransduction in living cells. Physiol Rev 2001;81:685-740.
27. MacQueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface 2013;10:179.
28. McKay WF, Peckham SM, Badura JM. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int Orthop 2007;31:729-734.
29. Schwarz C, Wulsten D, Ellinghaus A et al. Mechanical load modulates the stimulatory effect of BMP2 in a rat nonunion model. Tissue Eng Part A 2013;19:247-254.
30. Rhee ST, Buchman SR. Colocalization of c-Src (pp60src) and bone morphogenetic protein 2/4 expression during mandibular distraction osteogenesis: Invivoevidenceof their rolewithin an integrin-mediatedmechanotransduction pathway. Ann Plast Surg 2005;55:207-215.
31. Markides H, Kehoe O, Morris RH et al. Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells: A rheumatoid arthritis mouse model. Stem Cell Res Ther 2013; 4:126.
32. Gong C, Qi T, Wei X et al. Thermosensitive polymeric hydrogels as drug delivery systems. Curr Med Chem 2013;20:79-94.
33. Johnson TD, Christman KL. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opin Drug Deliv 2013;10:59-72.
34. Lin Z, Cao S, Chen X et al. Thermoresponsive hydrogels from phosphorylated ABA triblock copolymers: A potential scaffold for bone tissue engineering. Biomacromolecules 2013;14:2206-2214.