Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis

Clinical and Translational Immunology

Volumn 2, Issue 11, 2013, Pages

  Farrokhi, Vahid ^a   Nemati, Reza ^a   Nichols, Frank C ^b   Yao, Xudong ^a   Anstadt, Emily ^c   Fujiwara, Mai ^c   Grady, James ^c   Wakefield, Daniel ^c   Castro, Wanda ^c   Donaldson, James ^c   Clark, Robert B ^c  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF DENTAL MEDICINE   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

autoimmunity; biomarker; commensal bacteria; microbiome; multiple sclerosis; TLR2

Indexed keywords

EID: 84908336646     PISSN: None     EISSN: 20500068     Source Type: Journal    
DOI: 10.1038/cti.2013.11     Document Type: Article

References (19)

1. Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008; 453: 620–625.
2. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008; 455: 1109–1113.
3. Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 2008; 173: 1714–1723.
4. Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci USA 2011; 108: 11548–11553.
5. Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X et al. Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands. Infect Immun 2013; 81: 3479–3489.
6. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911–917.
7. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2011; 108 (Suppl 1): 4615–4622.
8. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010; 32: 815–827.
9. Chappert P, Bouladoux N, Naik S, Schwartz RH. Specific gut commensal flora locally alters T cell tuning to endogenous ligands. Immunity 2013; 38: 1198–1210.
10. Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R et al. Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-beta. Immunity 2013; 38: 1187–1197.
11. Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 2010; 107: 12204–12209.
12. Atarashi K, Tanoue T, Umesaki Y, Honda K. Regulation of Th17 cell differentiation by intestinal commensal bacteria. Benef Microbes 2010; 1: 327–334.
13. Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4: 337–349.
14. Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly Y et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569–573.
15. Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol 2006; 177: 7505–7509.
16. Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 2010; 16: 228–231.
17. Abt M.C, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg G et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 2012; 37: 158–170.
18. Perkins DJ, Polumuri SK, Pennini ME, Lai W, Xie P, Vogel SN. Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production. PLoS Pathogen 2013; 9: e1003479.
19. Nichols FC, Riep B, Mun J, Morton MD, Bojarski MT, Dewhirst FE et al. Structures and biological activity of phosphorylated dihydroceramides of Porphyromonas gingivalis. J Lipid Res 2004; 45: 2317–2330.