Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation

Biochemical and Biophysical Research Communications

Volumn 453, Issue 1, 2014, Pages 49-56

  Huang, Da ^a,b   Du, Xiaohong ^a,c   Yuan, Rongfa ^a,b   Chen, Leifeng ^a,b   Liu, Tiande ^a,b   Wen, Chongyu ^a,b   Huang, Mingwen ^a   Li, Ming ^a,b   Hao, Liang ^c   Shao, Jianghua ^a,b,c  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Province Engineering Research Center of Hepatobiliary Disease   (China)

^c Jiangxi Province Key Laboratory of Molecular Medicine   (China)

Author keywords

Hepatocellular carcinoma; Invasion; Metastasis; MMP2; Rock2; Ubiquitination

Indexed keywords

GELATINASE A; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 2; RHO KINASE; UNCLASSIFIED DRUG; MMP2 PROTEIN, HUMAN; ROCK2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER TISSUE; CARCINOMA CELL; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEGRADATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LUNG METASTASIS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; ENZYMOLOGY; GENETICS; HEPG2 CELL LINE; LIVER TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN DEGRADATION; SECONDARY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; PROTEOLYSIS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; UBIQUITINATION; UP-REGULATION;

EID: 84908321844     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.061     Document Type: Article

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