In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury

Genetics and Molecular Research

Volumn 13, Issue 4, 2014, Pages 8740-8748

  Zang, X J ^a   An, S X ^a   Feng, Z ^a   Xia, Y P ^a   Song, Y ^a   Yu, Q ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Apoptotic protein; Ischemia reperfusion; NGAL; Tubular epithelial cells

Indexed keywords

CASPASE 3; CREATININE; FAS ANTIGEN; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITROGEN; PROTEIN BAX; PROTEIN BCL 2; UREA; ACUTE PHASE PROTEIN; LIPOCALIN; NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PROTEIN, RAT; ONCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FAS GENE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY ISCHEMIA; MALE; NICK END LABELING; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RENAL PROTECTION; REPERFUSION INJURY; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; EPITHELIUM CELL; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

RATTUS;

ACUTE-PHASE PROTEINS; ANIMALS; APOPTOSIS; EPITHELIAL CELLS; KIDNEY; LIPOCALINS; MALE; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84908297926     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2014.October.27.15     Document Type: Article

References (21)

1. Alcantara O, Kalidas M, Baltathakis I and Boldt DH (2001). Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron. Exp. Hematol. 29: 1060-1069.
2. Brunelle JK and Letai A (2009). Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci. 122: 437-441.
3. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, et al. (2010). The BCL-2 family reunion. Mol. Cell 37: 299-310.
4. Cui LY, Yang S and Zhang J (2011). Protective effects of neutrophil gelatinase-associated lipocalin on hypoxia/ reoxygenation injury of HK-2 cells. Transplant. Proc. 43: 3622-3627.
5. Dagher PC (2004). Apoptosis in ischemic renal injury: roles of GTP depletion and p53. Kidney Int. 66: 506-509.
6. El Sabbahy M and Vaidya VS (2011). Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdiscip. Rev. Syst. Biol. Med. 3: 606-618.
7. Gong L, Yu H, ZhuGe Y and Yu Q (2012). Neutrophil gelatinase-associated lipocalin protects renal tubular epithelial cell in ischemic/reperfusion injury rats via apoptosis-regulating proteins. Ren. Fail. 34: 777-783.
8. Kanbay M, Kasapoglu B and Perazella MA (2010). Acute tubular necrosis and pre-renal acute kidney injury: utility of urine microscopy in their evaluation - a systematic review. Int. Urol. Nephrol. 42: 425-433.
9. Krauss G (2005) Intracellular Signal Transduction: The Protein Cascades of the MAP Kinase Pathways. In: Biochemistry of Signal Transdution and Regulation. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 389-392.
10. Mishra J, Ma Q, Prada A, Mitsnefes M, et al. (2003). Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J. Am. Soc. Nephrol. 14: 2534-2543.
11. Mishra J, Mori K, Ma Q, Kelly C, et al. (2004). Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 15: 3073-3082.
12. Mori K, Lee HT, Rapoport D, Drexler IR, et al. (2005). Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 115: 610-621.
13. Pop C and Salvesen GS (2009). Human caspases: activation, specificity, and regulation. J. Biol. Chem. 284: 21777-21781.
14. Raff U, Schneider R, Gambaryan S, Seibold S, et al. (2005). L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats. Nephron Physiol. 101: 39-50.
15. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, et al. (2006). Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr. Opin. Nephrol. Hypertens. 15: 442-449.
16. Sun X, Ge R, Cai Z, Sun H, et al. (2009). Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J. Inorg. Biochem. 103: 1074-1081.
17. Sutton TA (2009). Alteration of microvascular permeability in acute kidney injury. Microvasc. Res. 77: 4-7.
18. Takemoto K, Nagai T, Miyawaki A and Miura M (2003). Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. J. Cell Biol. 160: 235-243.
19. Tourneur L and Chiocchia G (2010). FADD: a regulator of life and death. Trends Immunol. 31: 260-269.
20. Yang J, Goetz D, Li JY, Wang W, et al. (2002). An iron delivery pathway mediated by a lipocalin. Mol. Cell 10: 1045-1056.
21. Zhao C, Ozaeta P, Fishpaugh J, Rupprecht K, et al. (2010). Structural characterization of glycoprotein NGAL, an early predictive biomarker for acute kidney injury. Carbohydr. Res. 345: 2252-2261.