Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages E4596-E4605

  Xue, Bo ^a   Leyrat, Cedric ^b   Grimes, Jonathan M ^b,c   Robinson, Robert C ^a,d  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b Division of Structural Biology   (United Kingdom)

^c DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Crystallography; Fluorescence; Molecular dynamics; Protein complex; Thermodynamics

Indexed keywords

ACTIN; G ACTIN; PROFILIN; THYMOSIN BETA4; THYMOSIN; THYMOSIN BETA(4);

ACTIN FILAMENT; ACTIN POLYMERIZATION; ALLOSTERISM; ANISOTROPY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NUCLEOTIDE BINDING SITE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE; SIMULATION; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CHEMISTRY; FLUORESCENCE POLARIZATION; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; POLYMERIZATION; RABBIT; X RAY CRYSTALLOGRAPHY;

ACTIN CYTOSKELETON; ACTINS; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE POLARIZATION; HUMANS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; POLYMERIZATION; PRINCIPAL COMPONENT ANALYSIS; PROFILINS; RABBITS; THYMOSIN;

EID: 84908274470     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412271111     Document Type: Article

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