Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE

Journal of Organic Chemistry

Volumn 79, Issue 20, 2014, Pages 9444-9450

  Veleti, Sri Kumar ^a   Lindenberger, Jared J ^a   Thanna, Sandeep ^a   Ronning, Donald R ^a   Sucheck, Steven J ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH;

CHEMICAL EQUATIONS; CONVERGENT SYNTHESIS; ENZYMATIC MECHANISMS; MYCOBACTERIUM TUBERCULOSIS; NATURAL SELECTION; REDUCTIVE AMINATION; STREPTOMYCES COELICOLOR; TRANSITION-STATE INHIBITORS;

BIOCHEMISTRY;

1,2,3,4,6 PENTA O ACETYL GLUCOPYRANOSE; 1,2;4,5 DI O ISOPROPYLIDENE BETA FRUCTOPYRANOSE; 2,3,4,6 TETRA O BENZYL 1 (5 AZIDO 3 O BENZYL 5 DEOXY BETA FRUCTOPYRANOSE) ALPHA GLUCOPYRANOSIDE; 2,5 DIDEOXY 3 O ALPHA GLUCOPYRANOSYL 2,5 IMINO MANNITOL; 3 O BENZYL 1,2 O ISOPROPYLIDENE BETA FRUCTOPYRANOSE; 3 O BENZYL 1,2:4,5 O ISOPROPYLIDENE BETA FRUCTOPYRANOSE; 4 METHYLPHENYL 1 THIO BETA GLUCOPYRANOSIDE; 4 METHYLPHENYL 2,3,4,6 TETRA O ACETYL BETA THIOGLUCOPYRANOSIDE; 4 O BENZOYL 3 O BENZYL 1,2 O ISOPROPYLIDENE BETA FRUCTOPYRANO; 5 AZIDO 3 O BENZYL 5 DEOXY 1,2 O ISOPROPYLIDENE BETA FRUCTOPYRANOSE; 5 AZIDO 4 O BENZOYL 3 O BENZYL 5 DEOXY 1,2, O ISOPROPYLIDENE BETA FRUCTOPYRANOSE; 5 O BENZOYL 3 O BENZYL 1,2 O ISOPROPYLIDENE BETA FRUCTOPYRANO; CARBON TETRACHLORIDE; DISACCHARIDE; ENZYME VARIANT; MALTOSYL TRANSFERASE; MYCOBACTERIUM TUBERCULOSIS GLGE; P METHYLPHENYL 2,3,4,6 TETRA O BENZYL 1 THIO BETA GLUCOPYRANOSIDE; PURINE NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINE DERIVATIVE; TRANSFERASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; 2,5-DIDEOXY-3-O-ALPHA-D-GLUCOPYRANOSYL-2,5-IMINO-D-MANNITOL; BACTERIAL PROTEIN; ENZYME INHIBITOR; GLUCAN; GLUCOSYLTRANSFERASE; MALTOSE 1-PHOSPHATE; MALTOSYLTRANSFERASE; SUGAR PHOSPHATE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; COLUMN CHROMATOGRAPHY; DRUG DESIGN; DRUG SYNTHESIS; EXTENSIVELY DRUG RESISTANT TUBERCULOSIS; MEDICATION COMPLIANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES COELICOLOR; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; SYNTHESIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DISACCHARIDES; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; GLUCANS; GLUCOSYLTRANSFERASES; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; SUGAR PHOSPHATES;

EID: 84908251249     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo501481r     Document Type: Article

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