The road to toxin-targeted therapeutic antibodies

mBio

Volumn 5, Issue 4, 2014, Pages

  Kozel, Thomas R ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN HEAVY CHAIN; NEUTRALIZING ANTIBODY; BACTERIUM ANTIBODY; ENTEROTOXIN;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL VIRULENCE; BINDING AFFINITY; EFFECTOR CELL; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; PASSIVE IMMUNIZATION; SEPSIS; SHOCK; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; ANIMAL; BACTEREMIA; FEMALE; GENE REARRANGEMENT; HUMAN; IMMUNOLOGY;

ANIMALS; ANTIBODIES, BACTERIAL; BACTEREMIA; ENTEROTOXINS; FEMALE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; SEPSIS; STAPHYLOCOCCUS AUREUS;

EID: 84908251047     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01477-14     Document Type: Article

References (10)

1. Porter RR. 1959. The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain. Biochem. J. 73:119-126.
2. Edelman GM, Cunningham BA, Gall WE, Gottlieb PD, Rutishauser U, Waxdal MJ. 1969. The covalent structure of an entire gamma G immunoglobulin molecule. Proc. Natl. Acad. Sci. U. S. A. 63:78-85. http://dx.doi.org/10.1073/pnas.63.1.78.
3. Nimmerjahn F, Ravetch JV. 2006. Fc_receptors: old friends and new family members. Immunity 24:19-28. http://dx.doi.org/10.1016/j.immuni.2005.11.010.
4. Tudor D, Yu H, Maupetit J, Drillet AS, Bouceba T, Schwartz-Cornil I, Lopalco L, Tuffery P, Bomsel M. 2012. Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. Proc. Natl. Acad. Sci. U. S. A. 109:12680-12685. http://dx.doi.org/10.1073/pnas.1200024109.
5. Dam TK, Torres M, Brewer CF, Casadevall A. 2008. Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand. J. Biol. Chem. 283:31366-31370. http://dx.doi.org/10.1074/jbc.M806473200.
6. Hovenden M, Hubbard MA, Aucoin DP, Thorkildson P, Reed DE, Welch WH, Lyons CR, Lovchik JA, Kozel TR. 2013. IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis. PLoS Pathog. 9(4):e1003306. http://dx.doi.org/10.1371/journal.ppat.1003306.
7. Hubbard MA, Thorkildson P, Kozel TR, Aucoin DP. 2013. Constant domains influence binding of mouse-human chimeric antibodies to the capsular polypeptide of Bacillus anthracis. Virulence 4:483-488. http://dx.doi.org/10.4161/viru.25711.
8. Abboud N, Chow SK, Saylor C, Janda A, Ravetch JV, Scharff MD, Casadevall A. 2010. A requirement for Fc_R in antibody-mediated bacterial toxin neutralization. J. Exp. Med. 207:2395-2405. http://dx.doi.org/10.1084/jem.20100995.
9. Varshney AK, Wang X, Aguilar JL, Scharff MD, Fries BC. 2014. Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. mBio 5(3):e01007-e01014. http://dx.doi.org/10.1128/mBio.01007-14.
10. Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC. 2011. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. J. Biol. Chem. 286:9737-9747. http://dx.doi.org/10.1074/jbc.M110.212407.