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Volumn 34, Issue 10, 2014, Pages 1061-1076

Cangrelor: A novel intravenous antiplatelet agent with a questionable future

Author keywords

acute coronary syndrome; AR C69931MX; cangrelor; clopidogrel; P2Y12 inhibitor; percutaneous coronary intervention; prasugrel; ticagrelor

Indexed keywords

CANGRELOR; CLOPIDOGREL; CREATINE KINASE MB; PLACEBO; PRASUGREL; TICAGRELOR; ADENOSINE PHOSPHATE; ANTITHROMBOCYTIC AGENT; PURINERGIC P2Y RECEPTOR ANTAGONIST;

EID: 84908235509     PISSN: 02770008     EISSN: 18759114     Source Type: Journal    
DOI: 10.1002/phar.1471     Document Type: Article
Times cited : (19)

References (45)
  • 1
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2013 update: A report from the American Heart Association
    • et al.
    • Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 2013; 127: e6-245.
    • (2013) Circulation , vol.127 , pp. e6-e245
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3
  • 2
    • 84855992555 scopus 로고    scopus 로고
    • 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
    • et al.
    • Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol 2011; 58: e44-122.
    • (2011) J Am Coll Cardiol , vol.58 , pp. e44-e122
    • Levine, G.N.1    Bates, E.R.2    Blankenship, J.C.3
  • 3
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous intervention: The PCI-CURE study
    • et al.
    • Mehta SR, Yusuf S, Peters RJG, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous intervention: the PCI-CURE study. Lancet 2001; 358: 527-33.
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.G.3
  • 4
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • et al.
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-15.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 5
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • et al.
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-57.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 6
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • et al.
    • Yusuf S, Zhao F, Meta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Meta, S.R.3
  • 8
    • 84908239327 scopus 로고    scopus 로고
    • Eli Lilly and Company Indianapolis, IN
    • Eli Lilly and Company. Effient (prasugrel) package insert. Indianapolis, IN; 2013.
    • (2013) Effient (Prasugrel) Package Insert
  • 9
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes
    • et al.
    • Montalescot G, Sideris G, Meuleman C, et al. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes. J Am Coll Cardiol 2006; 48: 931-8.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 931-938
    • Montalescot, G.1    Sideris, G.2    Meuleman, C.3
  • 10
    • 84873530056 scopus 로고    scopus 로고
    • Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarction
    • et al.
    • Alexopoulos D, Xanthopoulou I, Gkizas V, et al. Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv 2012; 5: 797-804.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 797-804
    • Alexopoulos, D.1    Xanthopoulou, I.2    Gkizas, V.3
  • 11
    • 78649374317 scopus 로고    scopus 로고
    • Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest
    • Bjelland TW, Hjertner O, Klepstad P, Kaisen K, Dale O, Haugen BO,. Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest. Resuscitation 2010; 81: 1627-31.
    • (2010) Resuscitation , vol.81 , pp. 1627-1631
    • Bjelland, T.W.1    Hjertner, O.2    Klepstad, P.3    Kaisen, K.4    Dale, O.5    Haugen, B.O.6
  • 12
    • 84873410107 scopus 로고    scopus 로고
    • Hypothermia in acute coronary syndrome: Brain salvage versus stent thrombosis?
    • et al.
    • Penela D, Magaldi M, Fontanals J, et al. Hypothermia in acute coronary syndrome: brain salvage versus stent thrombosis? J Am Coll Cardio 2013; 61: 686-7.
    • (2013) J Am Coll Cardio , vol.61 , pp. 686-687
    • Penela, D.1    Magaldi, M.2    Fontanals, J.3
  • 13
    • 83155173970 scopus 로고    scopus 로고
    • 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • et al.
    • Hillis LD, Smith PK, Anderson JL, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2011; 124: e652-735.
    • (2011) Circulation , vol.124 , pp. e652-e735
    • Hillis, L.D.1    Smith, P.K.2    Anderson, J.L.3
  • 18
    • 0035085132 scopus 로고    scopus 로고
    • 2T receptor antagonist AR-C69931MX assessing safety, tolerability, and activity in patients with acute coronary syndromes
    • 2T receptor antagonist AR-C69931MX assessing safety, tolerability, and activity in patients with acute coronary syndromes. Thromb Haemost 2001; 85: 401-7.
    • (2001) Thromb Haemost , vol.85 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 20
    • 84908254164 scopus 로고    scopus 로고
    • Chrono-log Corporation. Havertown, PA Accumetrics, Inc. San Diego, CA. Available from. Accessed February 27, 2014
    • Chrono-log Corporation. Havertown, PA. VerifyNow PRU Test. Accumetrics, Inc. San Diego, CA. Available from http://www.chronolog.com. Accessed February 27, 2014.
    • VerifyNow PRU Test
  • 21
    • 84908254164 scopus 로고    scopus 로고
    • Accumetrics, Inc. San Diego, CA. Available from. Accessed February 27, 2014
    • VerifyNow PRU Test. Accumetrics, Inc. San Diego, CA. Available from http://www.accumetrics.com/products/verifynow-prutest. Accessed February 27, 2014.
    • VerifyNow PRU Test
  • 22
    • 84856023997 scopus 로고    scopus 로고
    • Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: A randomized controlled trial
    • et al.
    • Angiolillo DJ, Firstenberg MS, Price MJ, et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. JAMA 2012; 307: 265-74.
    • (2012) JAMA , vol.307 , pp. 265-274
    • Angiolillo, D.J.1    Firstenberg, M.S.2    Price, M.J.3
  • 24
    • 0036015034 scopus 로고    scopus 로고
    • Safety profile and tolerability of intravenous ARC69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction
    • Jacobsson F, Swahn E, Wallentin L, Ellborg M,. Safety profile and tolerability of intravenous ARC69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction. Clin Ther 2002; 24: 752-65.
    • (2002) Clin Ther , vol.24 , pp. 752-765
    • Jacobsson, F.1    Swahn, E.2    Wallentin, L.3    Ellborg, M.4
  • 25
    • 38649113576 scopus 로고    scopus 로고
    • Transitioning patients from cangrelor to clopidogrel: Pharmacodynamic evidence of a competitive effect
    • Steinhubl SR, Oh JJ, Oestreich JH, Ferraris S, Charnigo R, Akers WS,. Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect. Thromb Res 2008; 121: 527-34.
    • (2008) Thromb Res , vol.121 , pp. 527-534
    • Steinhubl, S.R.1    Oh, J.J.2    Oestreich, J.H.3    Ferraris, S.4    Charnigo, R.5    Akers, W.S.6
  • 27
    • 71849087338 scopus 로고    scopus 로고
    • Platelet inhibition with cangrelor in patients undergoing PCI
    • et al.
    • Harrington RA, Stone GW, McNulty S, et al. Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med 2009; 361: 2318-29.
    • (2009) N Engl J Med , vol.361 , pp. 2318-2329
    • Harrington, R.A.1    Stone, G.W.2    McNulty, S.3
  • 28
    • 34247558672 scopus 로고    scopus 로고
    • Clinical endpoints in coronary stent trials: A case for standardized definitions
    • et al.
    • Cutlip DE, Windecker S, Mehran R, et al. Clinical endpoints in coronary stent trials: a case for standardized definitions. Circulation 2007; 115: 2344-51.
    • (2007) Circulation , vol.115 , pp. 2344-2351
    • Cutlip, D.E.1    Windecker, S.2    Mehran, R.3
  • 29
    • 33751221316 scopus 로고    scopus 로고
    • Bivalirudin for patients with acute coronary syndromes
    • et al.
    • Stone GW, McLaurin BT, Cox DA, et al. Bivalirudin for patients with acute coronary syndromes. N Engl J Med 2006; 355: 2203-16.
    • (2006) N Engl J Med , vol.355 , pp. 2203-2216
    • Stone, G.W.1    McLaurin, B.T.2    Cox, D.A.3
  • 30
    • 0027240597 scopus 로고
    • An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction
    • The GUSTO Investigators.
    • The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993; 329: 673-82.
    • (1993) N Engl J Med , vol.329 , pp. 673-682
  • 31
    • 0023258694 scopus 로고
    • Thrombolysis in Myocardial Infarction (TIMI) trial, phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge
    • et al.
    • Chesebro JH, Knatterud G, Roberts R, et al. Thrombolysis in Myocardial Infarction (TIMI) trial, phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation 1987; 76: 142-54.
    • (1987) Circulation , vol.76 , pp. 142-154
    • Chesebro, J.H.1    Knatterud, G.2    Roberts, R.3
  • 32
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with cangrelor during PCI
    • et al.
    • Bhatt DL, Lincoff AM, Gibson CM, et al. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med 2009; 361: 2330-41.
    • (2009) N Engl J Med , vol.361 , pp. 2330-2341
    • Bhatt, D.L.1    Lincoff, A.M.2    Gibson, C.M.3
  • 33
    • 84875779761 scopus 로고    scopus 로고
    • Effect of platelet inhibition with cangrelor during PCI on ischemic events
    • et al.
    • Bhatt DL, Stone GW, Mahaffey KW, et al. Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med 2013; 368: 1303-13.
    • (2013) N Engl J Med , vol.368 , pp. 1303-1313
    • Bhatt, D.L.1    Stone, G.W.2    Mahaffey, K.W.3
  • 34
    • 84908237211 scopus 로고    scopus 로고
    • Bristol-Myers Squibb/Sanofi Pharmaceutical Partnership. NJ: Bridgewater.
    • Bristol-Myers Squibb/Sanofi Pharmaceutical Partnership. Plavix (clopidogrel) package insert. NJ: Bridgewater, 2013.
    • (2013) Plavix (Clopidogrel) Package Insert
  • 35
    • 84867793423 scopus 로고    scopus 로고
    • 2012 Update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations
    • et al.
    • Ferraris VA, Saha SP, Oestrich JH, et al. 2012 Update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations. Ann Thorac Surg 2012; 94: 1761-81.
    • (2012) Ann Thorac Surg , vol.94 , pp. 1761-1781
    • Ferraris, V.A.1    Saha, S.P.2    Oestrich, J.H.3
  • 36
    • 79959550517 scopus 로고    scopus 로고
    • Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium
    • et al.
    • Mehran R, Rao SV, Bhatt DL, et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 2011; 123: 2736-47.
    • (2011) Circulation , vol.123 , pp. 2736-2747
    • Mehran, R.1    Rao, S.V.2    Bhatt, D.L.3
  • 37
    • 84877997976 scopus 로고    scopus 로고
    • Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery
    • et al.
    • Firstenberg MS, Dyke CM, Angiolillo DJ, et al. Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery. Heart Surg Forum 2013; 16: E60-9.
    • (2013) Heart Surg Forum , vol.16 , pp. E60-E69
    • Firstenberg, M.S.1    Dyke, C.M.2    Angiolillo, D.J.3
  • 41
    • 84908222791 scopus 로고    scopus 로고
    • The Medicines Company to discuss the cangrelor update Accessed May 7, 2014
    • The Medicines Company to discuss the cangrelor update. Conference call May 1, 2014, at 0830 EST. Available from www.themedicinescompany.com. Accessed May 7, 2014.
    • Conference Call May 1, 2014, at 0830 EST
  • 42
    • 84884485648 scopus 로고    scopus 로고
    • Prognostic value of access and non-access sites bleeding after percutaneous coronary intervention
    • et al.
    • Ndrepepa G, Neumann FJ, Richardt G, et al. Prognostic value of access and non-access sites bleeding after percutaneous coronary intervention. Circ Cardiovasc Interv 2013; 6: 354-61.
    • (2013) Circ Cardiovasc Interv , vol.6 , pp. 354-361
    • Ndrepepa, G.1    Neumann, F.J.2    Richardt, G.3
  • 43
    • 84875213993 scopus 로고    scopus 로고
    • Red blood cell transfusion and mortality among patients hospitalized for acute coronary syndromes: A systematic review
    • Garfinkle M, Lawler PR, Filion KB, Eisenberg MJ,. Red blood cell transfusion and mortality among patients hospitalized for acute coronary syndromes: a systematic review. Int J Cardio 2013; 164: 151-7.
    • (2013) Int J Cardio , vol.164 , pp. 151-157
    • Garfinkle, M.1    Lawler, P.R.2    Filion, K.B.3    Eisenberg, M.J.4
  • 44
    • 84883624073 scopus 로고    scopus 로고
    • Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes: An analysis from the prospective, randomized PLATO trial
    • et al.
    • Steg PG, Harrington RA, Emanuelsson H, et al. Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes: an analysis from the prospective, randomized PLATO trial. Circulation 2013; 128: 1055-65.
    • (2013) Circulation , vol.128 , pp. 1055-1065
    • Steg, P.G.1    Harrington, R.A.2    Emanuelsson, H.3
  • 45
    • 80052741598 scopus 로고    scopus 로고
    • Efficacy and safety of intensive antiplatelet therapy with prasugrel from TRITON-TIMI 38 in a core clinical cohort defined by worldwide regulatory agencies
    • et al.
    • Wiviott SD, Desai N, Murphy SA, et al. Efficacy and safety of intensive antiplatelet therapy with prasugrel from TRITON-TIMI 38 in a core clinical cohort defined by worldwide regulatory agencies. Am J Cardiol 2011; 108: 905-11.
    • (2011) Am J Cardiol , vol.108 , pp. 905-911
    • Wiviott, S.D.1    Desai, N.2    Murphy, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.