Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease

Alzheimer's and Dementia

Volumn 10, Issue 5, 2014, Pages S277-S283.e10

  Lalli, Matthew A ^a   Cox, Hannah C ^b   Arcila, Mary L ^a   Cadavid, Liliana ^c   Moreno, Sonia ^c   Garcia, Gloria ^c   Madrigal, Lucia ^c   Reiman, Eric M ^d   Arcos Burgos, Mauricio ^c,e   Bedoya, Gabriel ^c   Brunkow, Mary E ^b   Glusman, Gustavo ^b   Roach, Jared C ^b   Hood, Leroy ^b   Kosik, Kenneth S ^a   Lopera, Francisco ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^c UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^d BANNER ALZHEIMER S INSTITUTE   (United States)

^e AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Alzheimer's disease; population genetics; PSEN1; whole genome sequencing

Indexed keywords

PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

AFRICAN; ALLELE; ALZHEIMER DISEASE; AMERICAN INDIAN; ARTICLE; CHROMOSOME; COLOMBIA; CONTROLLED STUDY; DEMOGRAPHY; EUROPEAN; FEMALE; GENE MUTATION; GENOME; GEOGRAPHIC ORIGIN; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN EUROPEAN; CAUCASIAN; FOUNDER EFFECT; GENETIC PREDISPOSITION; GENETICS; INHERITANCE; MUTATION; ONSET AGE;

AGE OF ONSET; ALZHEIMER DISEASE; COLOMBIA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FOUNDER EFFECT; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INHERITANCE PATTERNS; MUTATION; PRESENILIN-1;

EID: 84908223294     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2013.09.005     Document Type: Article

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