Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Hung, Li Man ^a   Huang, Jiung Pang ^a   Liao, Jiuan Miaw ^b   Yang, Meng Hsuan ^a   Li, Dai Er ^a   Day, Yuan Ji ^c   Huang, Shiang Suo ^b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Diabetes; Insulin; Ischemic stroke; Nitric oxide; Peroxynitrite; Superoxide

Indexed keywords

GLUCOSE; INSULIN ZINC SUSPENSION; NITRIC OXIDE; PEROXYNITRITE; SUPEROXIDE; ANTIDIABETIC AGENT; INSULIN; PEROXYNITROUS ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CARBON DIOXIDE TENSION; BLOOD OXYGEN TENSION; BLOOD PH; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL MIGRATION; CELL TRANSMIGRATION; CONTROLLED STUDY; CREMASTER MUSCLE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOINSULINEMIA; INSULIN BLOOD LEVEL; LEFT HEMISPHERE; LEUKOCYTE ADHERENCE; MALE; MUSCLE STRENGTH; NEUROLOGIC DISEASE; NONHUMAN; RAT; REPERFUSION INJURY; RIGHT HEMISPHERE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; VENULE; WEIGHT REDUCTION; ACUTE DISEASE; ANIMAL; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; LONG EVANS RAT; METABOLISM; PATHOLOGY; STROKE;

ACUTE DISEASE; ANIMALS; BRAIN ISCHEMIA; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INSULIN; MALE; NITRIC OXIDE; PEROXYNITROUS ACID; RATS; RATS, LONG-EVANS; STROKE; SUPEROXIDES;

EID: 84908217308     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-014-0092-0     Document Type: Article

References (33)

1. Olmez I, Ozyurt H: Reactive oxygen species and ischemic cerebrovascular disease. Neurochem Int 2012, 60: 208-212.
2. Malinski T, Bailey F, Zhang ZG, Chopp M: Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 1993, 13:355-358.
3. Fabian RH, Kent TA: Superoxide anion protection during reperfusion is reduced by an antineutrophil antibody after prolonged cerebral ischemia. Free Radic Biol Med 1999, 26:355-361.
4. Maritim AC, Sanders RA, Watkins JB 3rd: Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003, 17:24-38.
5. Calver A, Collier J, Valiance P: Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 1992, 90:2548-2554.
6. Shiekh GA, Ayub T, Khan SN, Dar R, Andrabi KI: Reduced nitrate level in individuals with hypertension and diabetes. J Cardiovasc Dis Res 2011, 2:172-176.
7. Astaneie F, Afshari M, Mojtahedi A, Mostafalou S, Zamani MJ, Larijani B, Abdollahi M: Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res 2005, 36:376-381.
8. Ferlito S, Gallina M: Nitrite plasma levels in type 1 and 2 diabetics with and without complications. Panminerva Med 1998, 40:304-308.
9. LeMay DR, Gehua L, Zelenock GB, D'Alecy LG: Insulin administration protects neurologic function in cerebral ischemia in rats. Stroke 1988, 19:1411-1419.
10. Warner DS, Gionet TX, Todd MM, McAllister AM: Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats. Stroke 1992, 23:1775-1780.
11. Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001, 50:537-546.
12. Huang SS, Tsai SK, Chih CL, Chiang LY, Hsieh HM, Teng CM, Tsai MC: Neuroprotective effect of hexasulfobutylated C60 on rats subjected to focal cerebral ischemia. Free Radic Biol Med 2001, 30:643-649.
13. Tsai SK, Hung LM, Fu YT, Cheng H, Nien MW, Liu HY, Zhang FB, Huang SS: Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. J Vasc Surg 2007, 46:346-353.
14. Bergmeyer HU, Bernt E: Lactate dehydrogenase. UV-assay with Pyruvate and NADH. In Methods of Enzymatic Analysis, Volume 2. New York: Academic Press; 1974:574-579.
15. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H: Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
16. Huang JP, Huang SS, Deng JY, Day YJ, Hung LM: Insulin and resveratrol act synergistically preventing cardiac dysfunction in diabetes but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. Free Radic Biol Me 2010, 49:1710-1721.
17. Chang CC, Yang MH, Tung HC, Chang CY, Tsai YL, Huang JP, Yen TH, Hung LM: Resveratrol exhibits differential protective effects on fast- and slow-twitch muscles in streptozotocin-induced diabetic rats. J Diabetes 2014, 6:60-67.
18. Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR: Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. Biochem Pharmacol 2013, 85:367-375.
19. Boybeyi Ö, Yazici ̄, Ünlü G, Aslan MK, Soyer T: Intravital microscopic evaluation of cremasteric microcirculation in experimental testicular torsion. J Pediatr Urol 2013, 9:40-44.
20. Huang SS, Wei FC, Hung LM: Ischemic preconditioning attenuates postischemic leukocyte-endothelial cell interactions: role of nitric oxide and protein kinase C. Cir J 2006, 70:1070-1075.
21. Bonnardel-Phu E, Vicaut E: Reactive oxygen species and acute modulation of albumin microvascular leakage in the microcirculation of diabetic rats in vivo. J Vasc Res 2000, 37:32-38.
22. Pettersson US, Christoffersson G, Massena S, Ahl D, Jansson L, Henriksnäs J: Increased recruitment but impaired function of leukocytes during inflammation in mouse models of type 1 and type 2 diabetes. PLoS One 2011, 6:e22480.
23. Folli F, Corradi D, Fanti P, Davalli A, Paez A, Giaccari A, Perego C, Muscogiuri G: The role of oxidative stress in the pathogenesis of type 2 diabetesmellitus micro-and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 2011, 7:313-324.
24. Atkinson MA, Maclaren NK: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994, 331:1428.
25. Stevens RB, Sutherland DE, Ansite JD, Saxena M, Rossini TJ, Levay-Young BK, Hering BJ, Mills CD: Insulin down-regulates the inducible nitric oxide synthase pathway: nitric oxide as cause and effect of diabetes? J Immunol 1997, 159:5329-5335.
26. Kitayama J, Faraci FM, Gunnett CA, Heistad DD: Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke 2006, 37: 2129-2133.
27. Afanas'ev I: Signaling of reactive oxygen and nitrogen species in Diabetes mellitus. Oxid Med Cell Longev 2010, 3:361-373.
28. Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007, 87:315-424.
29. Pacher P, Szabo C: Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am J Pathol 2008, 173:2-13.
30. Creager MA, Lüscher TF, Cosentino F, Beckman JA: Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003, 108:1527-1532.
31. Wu G, Meininger CJ: Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. Am J Physiol 1995, 269:H1312-H1318.
32. Huang SS, Lu YJ, Huang JP, Wu YT, Day YJ, Hung LM: The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. J Vasc Surg 2014, 59:483-491.
33. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T: Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001, 88:E14-E22.