Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation

Cancer Letters

Volumn 355, Issue 2, 2014, Pages 210-216

  Lee, Sora ^a   Craig, Brian T ^a   Romain, Carmelle V ^a   Qiao, Jingbo ^a   Chung, Dai H ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT2; CDC42; N myc; Neuroblastoma; Transformation; Twist

Indexed keywords

MYC PROTEIN; PROTEIN CDC42; PROTEIN KINASE B BETA; TRANSCRIPTION FACTOR TWIST; MYCN PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUROBLASTOMA CELL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; CELL TRANSFORMATION; GENETICS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL LINE;

CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; NEUROBLASTOMA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 84908214686     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.08.033     Document Type: Article

References (28)

1. Modak S., Cheung N.K. Neuroblastoma: therapeutic strategies for a clinical enigma. Cancer Treat. Rev 2010, 36:307-317.
2. Maris J.M., Hogarty M.D., Bagatell R., Cohn S.L. Neuroblastoma. Lancet 2007, 369:2106-2120.
3. van Noesel M.M., Versteeg R. Pediatric neuroblastomas: genetic and epigenetic 'danse macabre'. Gene 2004, 325:1-15.
4. Rathinam R., Berrier A., Alahari S.K. Role of Rho GTPases and their regulators in cancer progression. Front. Biosci. (Landmark Ed) 2011, 16:2561-2571.
5. Tang Y., Olufemi L., Wang M.T., Nie D. Role of Rho GTPases in breast cancer. Front. Biosci 2008, 13:759-776.
6. Leve F., Morgado-Diaz J.A. Rho GTPase signaling in the development of colorectal cancer. J. Cell. Biochem 2012, 113:2549-2559.
7. Stengel K., Zheng Y. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell. Signal 2011, 23:1415-1423.
8. Tucci M.G., Lucarini G., Brancorsini D., Zizzi A., Pugnaloni A., Giacchetti A., et al. Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma. Br. J. Dermatol 2007, 157:1212-1216.
9. Ma J., Xue Y., Liu W., Yue C., Bi F., Xu J., et al. Role of activated rac1/cdc42 in mediating endothelial cell proliferation and tumor angiogenesis in breast cancer. PLoS ONE 2013, 8. e66275.
10. Liu M., Lang N., Qiu M., Xu F., Li Q., Tang Q., et al. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int. J. Cancer 2011, 128:1269-1279.
11. Higuchi M., Masuyama N., Fukui Y., Suzuki A., Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr. Biol 2001, 11:1958-1962.
12. Arboleda M.J., Lyons J.F., Kabbinavar F.F., Bray M.R., Snow B.E., Ayala R., et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003, 63:196-206.
13. Qiao J., Lee S., Paul P., Qiao L., Taylor C.J., Schlegel C., et al. AKT2 regulates metastatic potential in neuroblastoma. PLoS ONE 2013, 8. e56382.
14. Cheng G.Z., Zhang W., Wang L.H. Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Res 2008, 68:957-960.
15. Chen Z.F., Behringer R.R. Twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev 1995, 9:686-699.
16. Eckert M.A., Lwin T.M., Chang A.T., Kim J., Danis E., Ohno-Machado L., et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011, 19:372-386.
17. Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
18. Valsesia-Wittmann S., Magdeleine M., Dupasquier S., Garin E., Jallas A.C., Combaret V., et al. Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells. Cancer Cell 2004, 6:625-630.
19. Kang J.H., Rychahou P.G., Ishola T.A., Qiao J., Evers B.M., Chung D.H. MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Biochem. Biophys. Res. Commun 2006, 351:192-197.
20. Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.F., Biedler J.L., et al. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 2004, 6:838-845.
21. Ponten J. Spontaneous and virus induced transformation in cell culture. Virol. Monogr 1971, 8:1-253.
22. Brodeur G.M., Seeger R.C., Schwab M., Varmus H.E., Bishop J.M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984, 224:1121-1124.
23. Valentijn L.J., Koppen A., van Asperen R., Root H.A., Haneveld F., Versteeg R. Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes. Cancer Res 2005, 65:3136-3145.
24. Hoek K., Rimm D.L., Williams K.R., Zhao H., Ariyan S., Lin A., et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res 2004, 64:5270-5282.
25. Kwok W.K., Ling M.T., Lee T.W., Lau T.C., Zhou C., Zhang X., et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 2005, 65:5153-5162.
26. Qiu R.G., Abo A., McCormick F., Symons M. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol 1997, 17:3449-3458.
27. Tolias K.F., Cantley L.C., Carpenter C.L. Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem 1995, 270:17656-17659.
28. Keely P.J., Westwick J.K., Whitehead I.P., Der C.J., Parise L.V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 1997, 390:632-636.