L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway

Immunology

Volumn 143, Issue 2, 2014, Pages 184-192

  Yu, Hong Ren ^a   Kuo, Ho Chang ^a   Huang, Li Tung ^a   Chen, Chih Cheng ^a   Tain, You Lin ^a   Sheen, Jiunn Ming ^a   Tiao, Mao Meng ^a   Huang, Hsin Chun ^a   Yang, Kuender D ^b   Ou, Chia Yo ^a   Hsu, Te Yao ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b Department of Medical Research Show Chwan Memorial Hospital in Chang Bing   (Taiwan)

Author keywords

Arginase; Interleukin 2; l arginine; Lymphocyte proliferation; Neonate

Indexed keywords

ARGINASE; ARGINASE I, HUMAN; ARGININE; HU ANTIGEN; IL2 PROTEIN, HUMAN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ADULT; AGE; ARTICLE; BLOOD; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECT; ENZYMOLOGY; FEMALE; FETUS BLOOD; HUMAN; IMMUNOLOGY; L-ARGININE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; METABOLISM; NEUTROPHIL; NEWBORN; PREGNANCY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TIME; YOUNG ADULT;

ARGINASE; INTERLEUKIN-2; L-ARGININE; LYMPHOCYTE PROLIFERATION; NEONATE;

ADULT; AGE FACTORS; ARGINASE; ARGININE; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FETAL BLOOD; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; NEUTROPHILS; PREGNANCY; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; YOUNG ADULT;

EID: 84908214415     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12300     Document Type: Article

References (38)

1. Wu G, Bazer FW, Davis TA et al. Arginine metabolism and nutrition in growth, health and disease. Amino Acids 2009; 37:153-68.
2. Li P, Yin YL, Li D, Kim SW, Wu G. Amino acids and immune function. Br J Nutr 2007; 98:237-52.
3. Jenkinson CP, Grody WW, Cederbaum SD. Comparative properties of arginases. Comp Biochem Physiol B Biochem Mol Biol 1996; 114:107-32.
4. Munder M, Eichmann K, Moran JM, Centeno F, Soler G, Modolell M. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol 1999; 163:3771-7.
5. Munder M, Mollinedo F, Calafat J et al. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 2005; 105:2549-56.
6. Munder M. Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol 2009; 158:638-51.
7. Munder M, Schneider H, Luckner C et al. Suppression of T-cell functions by human granulocyte arginase. Blood 2006; 108:1627-34.
8. Singer K, Gottfried E, Kreutz M, Mackensen A. Suppression of T-cell responses by tumor metabolites. Cancer Immunol Immunother 2011; 60:425-31.
9. Oberlies J, Watzl C, Giese T et al. Regulation of NK cell function by human granulocyte arginase. J Immunol 2009; 182:5259-67.
10. Kropf P, Baud D, Marshall SE et al. Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol 2007; 37:935-45.
11. Yang KD, Hill HR. Immune responses to infectious diseases: an evolutionary perspective. Pediatr Infect Dis J 1996; 15:355-64.
12. Goldmann DA. Prevention and management of neonatal infections. Infect Dis Clin North Am 1989; 3:779-813.
13. Yu HR, Chang JC, Chen RF et al. Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression. J Leukoc Biol 2003; 74:952-8.
14. Hou PC, Yu HR, Kuo HC et al. Different modulating effects of adenosine on neonatal and adult polymorphonuclear leukocytes. ScientificWorldJournal 2012; 2012:387923.
15. Wu G, Jaeger LA, Bazer FW, Rhoads JM. Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications. J Nutr Biochem 2004; 15:442-51.
16. Yu HR, Kuo HC, Huang HC et al. Identification of immunodeficient molecules in neonatal mononuclear cells by proteomic differential displays. Proteomics 2011; 11:3491-500.
17. Han J, Liu YL, Fan W et al. Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs. Amino Acids 2009; 37:643-51.
18. Tan B, Li XG, Kong X et al. Dietary l-arginine supplementation enhances the immune status in early-weaned piglets. Amino Acids 2009; 37:323-31.
19. Yu HR, Chen RF, Hong KC et al. IL-12-independent Th1 polarization in human mononuclear cells infected with varicella-zoster virus. Eur J Immunol 2005; 35:3664-72.
20. Yu HR, Kuo HC, Huang HC et al. Glyceraldehyde-3-phosphate dehydrogenase is a reliable internal control in Western blot analysis of leukocyte subpopulations from children. Anal Biochem 2011; 413:24-9.
21. Tain YL, Hsieh CS, Chen CC, Sheen JM, Lee CT, Huang LT. Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation. J Pineal Res 2010; 48:212-21.
22. Yu HR, Huang HC, Kuo HC et al. IFN-α production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways. Cell Mol Immunol 2011; 8:181-8.
23. + erythroid cells compromise neonatal host defence against infection. Nature 2013; 504:158-62.
24. Rodriguez PC, Quiceno DG, Ochoa AC. l-Arginine availability regulates T-lymphocyte cell-cycle progression. Blood 2007; 109:1568-73.
25. Rodriguez PC, Hernandez CP, Morrow K et al. l-Arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression. J Immunol 2010; 185:5198-204.
26. Zea AH, Rodriguez PC, Atkins MB et al. Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 2005; 65:3044-8.
27. Bronte V, Kasic T, Gri G et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 2005; 201:1257-68.
28. Whiteside TL. Down-regulation of ζ-chain expression in T cells: a biomarker of prognosis in cancer? Cancer Immunol Immunother 2004; 53:865-78.
29. Rodriguez PC, Quiceno DG, Zabaleta J et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res 2004; 64:5839-49.
30. Zea AH, Culotta KS, Ali J et al. Decreased expression of CD3ζ and nuclear transcription factor κB in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment. J Infect Dis 2006; 194:1385-93.
31. Morris CR, Kato GJ, Poljakovic M et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA 2005; 294:81-90.
32. Hibbs JB Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for l-arginine deiminase and imino nitrogen oxidation to nitrite. Science 1987; 235:473-6.
33. Ochoa JB, Strange J, Kearney P, Gellin G, Endean E, Fitzpatrick E. Effects of l-arginine on the proliferation of T lymphocyte subpopulations. JPEN J Parenter Enteral Nutr 2001; 25:23-9.
34. Suchner U, Heyland DK, Peter K. Immune-modulatory actions of arginine in the critically ill. Br J Nutr 2002; 87(Suppl. 1):S121-32.
35. Marin VB, Rodriguez-Osiac L, Schlessinger L, Villegas J, Lopez M, Castillo-Duran C. Controlled study of enteral arginine supplementation in burned children: impact on immunologic and metabolic status. Nutrition 2006; 22:705-12.
36. Zea AH, Rodriguez PC, Culotta KS et al. l-Arginine modulates CD3ζ expression and T cell function in activated human T lymphocytes. Cell Immunol 2004; 232:21-31.
37. Cantrell DA, Smith KA. The interleukin-2 T-cell system: a new cell growth model. Science 1984; 224:1312-6.
38. Barksdale AR, Bernard AC, Maley ME et al. Regulation of arginase expression by T-helper II cytokines and isoproterenol. Surgery 2004; 135:527-35.