Colchicine suppresses atrial fibrillation in failing heart

International Journal of Cardiology

Volumn 176, Issue 3, 2014, Pages 651-660

  Singhal, Rahul ^a   Chang, Shih Lin ^a,b   Chong, Eric ^a   Hsiao, Ya Wen ^a   Liu, Shuen Hsin ^c   Tsai, Yung Nan ^a   Hsu, Chiao Po ^a,b   Lin, Yenn Jiang ^a,b   Lo, Li Wei ^a,b   Ha, Trung Le ^a   Chen, Yao Chang ^d   Chen, Yi Jen ^e,f,g   Chiou, Chuen Wang ^b,f,g   Chen, Shih Ann ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Atrial fibrillation; Colchicine; Heart failure; PI3K AKT eNOS; Taxol

Indexed keywords

COLCHICINE; COLLAGEN; ION CHANNEL; MESSENGER RNA; PACLITAXEL; PROTEIN;

ACTION POTENTIAL; ANIMAL; ATRIAL FIBRILLATION; DISEASE MODEL; DRUG EFFECTS; HEART FAILURE; METABOLISM; POLYMERASE CHAIN REACTION; PROCEDURES; RABBIT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTION POTENTIALS; ANIMALS; ATRIAL FIBRILLATION; BLOTTING, WESTERN; COLCHICINE; COLLAGEN; DISEASE MODELS, ANIMAL; HEART FAILURE; ION CHANNELS; PACLITAXEL; POLYMERASE CHAIN REACTION; PROTEINS; RABBITS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84908205244     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.07.069     Document Type: Article

References (40)

1. W.B. Kannel, P.A. Wolf, E.J. Benjamin, and D. Levy Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates Am J Cardiol 82 1998 2N 9N
2. 2 + channel abnormalities: cause, consequence, or innocent bystander? Circ Res 85 1999 473 476
3. M.C. Wijffels, C.J. Kirchhof, R. Dorland, and M.A. Allessie Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats Circulation 92 1995 1954 1968
4. S. Peng, A.E. Lacerda, G.E. Kirsch, A.M. Brown, and A. Bruening-Wright The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes J Pharmacol Toxicol Methods 61 2010 277 286
5. G. Hart Cellular electrophysiology in cardiac hypertrophy and failure Cardiovasc Res 28 1994 933 946
6. E.C. Keung Calcium current is increased in isolated adult myocytes from hypertrophied rat myocardium Circ Res 64 1989 753 763
7. S. Nattel, A. Maguy, S. Le Bouter, and Y.H. Yeh Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation Physiol Rev 87 2007 425 456
8. S.L. Chang, Y.C. Chen, and Y.H. Yeh Heart failure enhanced pulmonary vein arrhythmogenesis and dysregulated sodium and calcium homeostasis with increased calcium sparks J Cardiovasc Electrophysiol 22 2011 1378 1386
9. D. Li, S. Fareh, T.K. Leung, and S. Nattel Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort Circulation 100 1999 87 95
10. M.F. Swartz, G.W. Fink, and C.J. Lutz Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery Heart Rhythm 6 2009 1415 1422
11. K. Tanaka, S. Zlochiver, and K.L. Vikstrom Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure Circ Res 101 2007 839 847
12. J.R. McMullen, F. Amirahmadi, and E.A. Woodcock Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy Proc Natl Acad Sci U S A 104 2007 612 617
13. L. Pretorius, X.J. Du, and E.A. Woodcock Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation Am J Pathol 175 2009 998 1009
14. G. Nuki Colchicine: its mechanism of action and efficacy in crystal-induced inflammation Curr Rheumatol Rep 10 2008 218 227
15. M. Imazio, A. Brucato, and P. Ferrazzi Colchicine reduces postoperative atrial fibrillation: results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy Circulation 124 2011 2290 2295
16. S.L. Chang, Y.C. Chen, and C.P. Hsu Electrophysiological characteristics of complex fractionated electrograms and high frequency activity in atrial fibrillation Int J Cardiol 168 2013 2289 2299
17. S.L. Chang, Y.C. Chen, and C.P. Hsu Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart Int J Cardiol 168 2013 4019 4026
18. K.K. Parker, L.K. Taylor, J.B. Atkinson, D.E. Hansen, and J.P. Wikswo The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias Eur J Pharmacol 417 2001 131 140
19. Z. Lu, C.Y. Wu, and Y.P. Jiang Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome Sci Transl Med 4 2012 131ra50
20. T. Shioi, P.M. Kang, and P.S. Douglas The conserved phosphoinositide 3-kinase pathway determines heart size in mice EMBO J 19 2000 2537 2548
21. T. Shioi, J.R. McMullen, and P.M. Kang Akt/protein kinase B promotes organ growth in transgenic mice Mol Cell Biol 22 2002 2799 2809
22. H. Ouadid, B. Albat, and J. Nargeot Calcium currents in diseased human cardiac cells J Cardiovasc Pharmacol 25 1995 282 291
23. S. Nattel, and M.A. Quantz Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms Cardiovasc Res 22 1988 808 817
24. D.M. Roden Taking the "idio" out of "idiosyncratic": predicting torsades de pointes Pacing Clin Electrophysiol 21 1998 1029 1034
25. H. Tsutsui, K. Ishihara, and Gt Cooper Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium Science 260 1993 682 687
26. H. Tagawa, N. Wang, T. Narishige, D.E. Ingber, M.R. Zile, and Gt Cooper Cytoskeletal mechanics in pressure-overload cardiac hypertrophy Circ Res 80 1997 281 289
27. A. Galli, and L.J. DeFelice Inactivation of l-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol Biophys J 67 1994 2296 2304
28. K. Saji, Y. Fukumoto, J. Suzuki, S. Fukui, J. Nawata, and H. Shimokawa Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in rats Tohoku J Exp Med 213 2007 139 148
29. S. Verheule, E. Wilson, Tt Everett, S. Shanbhag, C. Golden, and J. Olgin Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation Circulation 107 2003 2615 2622
30. J.N. Weiss, P.S. Chen, Z. Qu, H.S. Karagueuzian, S.F. Lin, and A. Garfinkel Electrical restitution and cardiac fibrillation J Cardiovasc Electrophysiol 13 2002 292 295
31. T.J. Wu, S.F. Lin, J.N. Weiss, C.T. Ting, and P.S. Chen Two types of ventricular fibrillation in isolated rabbit hearts: importance of excitability and action potential duration restitution Circulation 106 2002 1859 1866
32. R. Rouet, M.E. Worou, and P.E. Puddu Nifedipine blocks ondansetron electrophysiological effects in rabbit purkinje fibers and decreases early after depolarization incidence Curr Clin Pharmacol 7 2012 41 48
33. J. Alexandre, M. Schiariti, R. Rouet, and P.E. Puddu Rabbit ventricular myocardium undergoing simulated ischemia and reperfusion in a double compartment tissue bath: a model to investigate both antiarrhythmic and arrhythmogenic likelihood Int J Physiol Pathophysiol Pharmacol 5 2013 52 60
34. A. Ghigo, F. Morello, A. Perino, F. Damilano, and E. Hirsch Specific PI3K isoform modulation in heart failure: lessons from transgenic mice Curr Heart Fail Rep 8 2011 168 175
35. J.L. Samuel, B. Bertier, and L. Bugaisky Different distributions of microtubules, desmin filaments and isomyosins during the onset of cardiac hypertrophy in the rat Eur J Cell Biol 34 1984 300 306
36. C.E. Morris Mechanosensitive ion channels J Membr Biol 113 1990 93 107
37. H. Tsutsui, Y. Ishibashi, and M. Takahashi Chronic colchicine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats J Mol Cell Cardiol 31 1999 1203 1213
38. H.M. Himmel, and M. Hoffmann QTc shortening with a new investigational cancer drug: a brief case study J Pharmacol Toxicol Methods 62 2010 72 81
39. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655 1657
40. L. Yue, J. Xie, and S. Nattel Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation Cardiovasc Res 89 2011 744 753