Ozone oxidative preconditioning inhibits renal fibrosis induced by ischemia and reperfusion injury in rats

Experimental and Therapeutic Medicine

Volumn 8, Issue 6, 2014, Pages 1764-1768

  Wang, Lei ^a   Chen, Hui ^a   Liu, Xiu Heng ^a   Chen, Zhi Yuan ^a   Weng, Xiao Dong ^a   Qiu, Tao ^a   Liu, Lin ^a   Zhu, Heng Cheng ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Ischemia and reperfusion injury; Ozone oxidative preconditioning; Renal fibrosis

Indexed keywords

ALPHA SMA PROTEIN; ALPHA SMOOTH MUSCLE ACTIN; CREATININE; SMAD7 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FIBROSING ALVEOLITIS; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OZONE THERAPY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION QUANTITATIVE POLYMERASE CHAIN REACTION; RNA ISOLATION; SPECTROPHOTOMETRY; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

EID: 84908204174     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.2004     Document Type: Article

References (23)

1. Yun Y, Duan WG, Chen P, et al: Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats. Transplant Proc 41: 3597-3602, 2009.
2. Barri YM, Sanchez EQ, Jennings LW, et al: Acute kidney injury following liver transplantation: definition and outcome. Liver Transpl 15: 475-483, 2009.
3. Schrier RW, Wang W, Poole B and Mitra A: Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest 114: 5-14, 2004.
4. Nankivell BJ, Borrows RJ, Fung CL, et al: The natural history of chronic allograft nephropathy. N Engl J Med 349: 2326-2333, 2003.
5. Cook HT: The origin of renal fibroblasts and progression of kidney disease. Am J Pathol 176: 22-24, 2010.
6. Li R, Chung AC, Dong Y, et al: The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway. Kidney Int 84: 1129-1244, 2013.
7. Ni H, Chen J, Pan M, et al: FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease. J Mol Histol 44: 693-703, 2013.
8. Zeisberg M, Maeshima Y, Mosterman B and Kalluri R: Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 160: 2001-2008, 2002.
9. Zhang X, Yang J, Li Y and Liu Y: Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells. Am J Physiol Renal Physiol 288: F16-F26, 2005.
10. Nakao A, Afrakhte M, Morén A, et al: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389: 631-635, 1997.
11. Ren ZP, Sun LP, Xia YC and Tong QX: Effect of the protease inhibitor MG132 on the transforming growth factor-β/Smad signaling pathway in HSC-T6 cells. J Huazhong Univ Sci Technolog Med Sci 33: 501-504, 2013.
12. Ajamieh HH, Menendez S, Martinez-Sanchez G, et al: Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int 24: 55-62, 2004.
13. Ajamieh HH, Berlanga J, Merino N, et al: Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion. Transpl Int 18: 604-612, 2005.
14. Chen H, Xing B, Liu X, et al: Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. Eur J Pharmacol 581: 306-314, 2008.
15. Martinez-Sanchez G, Al-Dalain SM, Menendez S, et al: Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol 523: 151-161, 2005.
16. León Fernández OS, Pantoja M, Díaz Soto MT, et al: Ozone oxidative post-conditioning reduces oxidative protein damage in patients with disc hernia. Neurol Res 34: 59-67, 2012.
17. Leon OS, Menendez S, Merino N, et al: Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators Inflamm 7: 289-294, 1998.
18. Feitoza CQ, Goncalves GM, Semedo P, et al: Inhibition of COX 1 and 2 prior to renal ischemia/reperfusion injury decreases the development of fibrosis. Mol Med 14: 724-730, 2008.
19. Weng X, Shen H, Kuang Y, et al: Ischemic postconditioning inhibits the renal fibrosis induced by ischemia-reperfusion injury in rats. Urology 80: 481-484, 2012.
20. Liu Y: Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 69: 213-217, 2006.
21. Border WA and Noble NA: TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int 51: 1388-1396, 1997.
22. Kellenberger T, Krag S, Danielsen CC, et al: Differential effects of Smad3 targeting in a murine model of chronic kidney disease. Physiol Rep Dec 1: e00181, 2013.
23. Wang Y1, Zhang Z, Shen H, Lu Y, Li H, Ren X and Wu G. TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI. J Recept Signal Transduct Res 28: 413-428, 2008.