Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Barbisan, Fernanda ^a   De Rosso Motta, Jéssica ^a   Trott, Alexis ^b   Azzolin, Verônica ^a   Dornelles, Eduardo Bortoluzzi ^a   Marcon, Matheus ^a   Algarve, Thaís Doeler ^a   Duarte, Marta Maria Medeiros Frescura ^a   Mostardeiro, Clarice Pinheiro ^a   Unfer, Taís Cristina ^a   Schott, Karen Lilian ^a   Da Cruz, Ivana Beatrice Mânica ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSIDADE DO OESTE DE SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CASPASE 3; CASPASE 8; CATALASE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; METHOTREXATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; VALINE; ANTIOXIDANT; CASPASE; CYTOKINE; DIACETYLDICHLOROFLUORESCEIN; FLUORESCEIN DERIVATIVE; MESSENGER RNA;

ADULT; AEROBIC METABOLISM; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVITY; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN CARBONYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOD2 GENE; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM;

ANTIOXIDANTS; CASPASES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPID PEROXIDATION; METHOTREXATE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CARBONYLATION; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 84908192092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107299     Document Type: Article

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