Attrition through multiple stages of pre-treatment and ART HIV care in South Africa

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Fox, Matthew P ^a,b,c   Shearer, Kate ^b   Maskew, Mhairi ^b   Meyer Rath, Gesine ^a,b   Clouse, Kate ^b,d   Sanne, Ian ^b,e  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b Faculty of Health Sciences   (South Africa)

^c BOSTON UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e School of Clinical Medicine   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANTIRETROVIRAL THERAPY; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEATH; DRUG THERAPY; FEMALE; FOLLOW UP; HIV CARE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; OUTPATIENT DEPARTMENT; PATIENT CARE; PATIENT TRANSPORT; SOUTH AFRICA; CD4 LYMPHOCYTE COUNT; HIV INFECTIONS; IMMUNOLOGY; STATISTICS AND NUMERICAL DATA;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; FEMALE; HIV INFECTIONS; HUMANS; MALE; PATIENT CARE; SOUTH AFRICA;

EID: 84908181111     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110252     Document Type: Article

References (32)

1. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG (2009) Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 373: 48-57.
2. Eaton JW, Johnson LF, Salomon JA, Bärnighausen T, Bendavid E, et al. (2012) HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa. PLoS Med 9: e1001245.
3. Walensky RP, Ross EL, Kumarasamy N, Wood R, Noubary F, et al. (2013) Cost-effectiveness of HIV treatment as prevention in serodiscordant couples. N Engl J Med 369: 1715-1725.
4. Bendavid E, Brandeau ML, Wood R, Owens DK (2010) Comparative effectiveness of HIV testing and treatment in highly endemic regions. Arch Intern Med 170: 1347-1354.
5. Bärnighausen T, Bloom DE, Humair S (2012) Economics of antiretroviral treatment vs. circumcision for HIV prevention. Proc Natl Acad Sci U S A 109: 21271-21276.
6. El-Sadr WM, Affrunti M, Gamble T, Zerbe A (2010) Antiretroviral therapy: a promising HIV prevention strategy? J Acquir Immune Defic Syndr 55 Suppl 2: S116-21.
7. Cohen MS, Mastro TD, Cates W (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1077; author reply 1080-1.
8. Montaner JSG, Hogg R, Wood E, Kerr T, Tyndall M, et al. (2006) The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet 368: 531-536.
9. Hontelez JAC, Lurie MN, Bärnighausen T, Bakker R, Baltussen R, et al. (2013) Elimination of HIV in South Africa through expanded access to antiretroviral therapy: a model comparison study. PLoS Med 10: e1001534.
10. Hontelez JAC, de Vlas SJ, Tanser F, Bakker R, Bärnighausen T, et al. (2011) The impact of the new WHO antiretroviral treatment guidelines on HIV epidemic dynamics and cost in South Africa. PLoS One 6: e21919.
11. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365: 493-505.
12. Montaner JSG, Lima VD, Barrios R, Yip B, Wood E, et al. (2010) Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet 376: 532-539.
13. Das M, Chu PL, Santos G-M, Scheer S, Vittinghoff E, et al. (2010) Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS One 5: e11068.
14. Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, et al. (2010) Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 375: 2092-2098.
15. World Health Organization (2013) Antiretroviral therapy for HIV infection in adults and adolescents: Recommendations for a public health approach 2013 revisions. Geneva.
16. Rosen S, Fox MP (2011) Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLoS Med 8: e1001056.
17. Rosen S, Fox MP, Gill CJ (2007) Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med 4: e298.
18. Fox MP, Rosen S (2010) Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Trop Med Int Heal 15 Suppl 1: 1-15.
19. Fox M, Maskew M, MacPhail A (2013) Cohort Profile: The Themba Lethu Clinical Cohort, Johannesburg, South Africa. Int J Epidemiol 42: 430-439.
20. Fox M, Shearer K, Maskew M, Macleod W, Majuba P, et al. (2012) Treatment outcomes after 7 years of public-sector HIV treatment. AIDS 26: 1823-1828.
21. National Department of Health SA (2004) National antiretroviral treatment guidelines, first edition. Pretoria, South Africa.
22. National Department of Health South Africa (2010) Clinical Guidelines for the Managment of HIV & AIDS in Adults and Adolescents. South Africa.
23. Fox MP, Larson B, Rosen S (2012) Defining retention and attrition in pre-antiretroviral HIV care: proposals based on experience in Africa. Trop Med Int Health 17: 1235-1244.
24. Severe P, Juste MAJ, Ambroise A, Eliacin L, Marchand C, et al. (2010) Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N Engl J Med 363: 257-265.
25. Fox MP, Sanne IM, Conradie F, Zeinecker J, Orrell C, et al. (2010) Initiating patients on antiretroviral therapy at CD4 cell counts above 200 cells/microl is associated with improved treatment outcomes in South Africa. AIDS 24: 2041-2050.
26. Cain LE, Logan R, Robins JM, Sterne JAC, Sabin C, et al. (2011) When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Ann Intern Med 154: 509-515.
27. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, et al. (2009) Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med 360: 1815-1826.
28. Govindasamy D, van Schaik N, Kranzer K, Wood R, Mathews C, et al. (2011) Linkage to HIV Care from a Mobile Testing Unit in South Africa by Different CD4 Count Strata. J Acquir Immune Defic Syndr 58: 344-352.
29. Klein DJ, Bershteyn A, Eckhoff PA (2014) Dropout and re-enrollment: implications for epidemiological projections of treatment programs. AIDS 28 Suppl 1: S47-59.
30. Kranzer K, Zeinecker J, Ginsberg P, Orrell C, Kalawe NN, et al. (2010) Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa. PLoS One 5: e13801.
31. Kranzer K, Govindasamy D, Ford N, Johnston V, Lawn SD (2012) Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review. J Int AIDS Soc 15: 17383.
32. Mugglin C, Estill J, Wandeler G, Bender N, Egger M, et al. (2012) Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-analysis. Trop Med Int Health 17: 1509-1520.