Restoring Mucosal Integrity: "Closing the Gap" in the Treatment of Esophageal Eosinophilia

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 11, 2014, Pages 1830-1831

  Vela, Marcelo F ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE; PROTON PUMP INHIBITOR; ANTIINFLAMMATORY AGENT; STEROID; TIGHT JUNCTION PROTEIN;

EDITORIAL; ELECTRON MICROSCOPY; EOSINOPHILIA; EOSINOPHILIC ESOPHAGITIS; ESOPHAGEAL EOSINOPHILIA; ESOPHAGITIS; GASTROESOPHAGEAL REFLUX; IMMUNITY; STOMACH ACID; TREATMENT RESPONSE; EPITHELIUM; ESOPHAGUS; FEMALE; HUMAN; MALE; MUCOSA; PATHOLOGY; PATHOPHYSIOLOGY; TIGHT JUNCTION;

ANTI-INFLAMMATORY AGENTS; EOSINOPHILIA; EOSINOPHILIC ESOPHAGITIS; EPITHELIUM; ESOPHAGUS; FEMALE; HUMANS; MALE; MUCOUS MEMBRANE; PROTON PUMP INHIBITORS; STEROIDS; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS;

EID: 84908180761     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2014.07.046     Document Type: Editorial

References (16)

1. Dellon E.S. Diagnosis and management of eosinophilic esophagitis. Clin Gastroenterol Hepatol 2012, 10:1066-1078.
2. Liacouras C.A., Furuta G.T., Hirano I., et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. JAllergy Clin Immunol 2011, 128:3-20.
3. Dellon E.S., Gonsalves N., Hirano I., et al. ACG clinical guideline: evidence based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis. Am J Gastroenterol 2013, 108:679-692.
4. Dellon ES, Speck O, Woodward K, etal. Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study. Am J Gastroenterol 2103;108:1854-1860.
5. Dellon E.S., Speck O., Woodward K., et al. Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study. Clin Gastroetnterol Hepatol 2014 Jun 30, Epub ahead of print.
6. Spechler S.J., Genta R.M., Souza R.F. Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol 2007, 102:1301-1306.
7. Tobey N.A., Carson J.L., Alkiek R.A., et al. Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996, 111:1200-1205.
8. Calabrese C., Bortolotti M., Fabbri A., et al. Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment. Am J Gastroenterol 2005, 100:537-542.
9. Vela M.F., Craft B.M., Sharma N., et al. Refractory heartburn: comparison of intercellular space diameter in documented GERD vs functional heartburn. Am J Gastroenterol 2011, 106:844-850.
10. Farre R., van Malenstein H., De Vos R., et al. Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces. Gut 2008, 57:1366-1374.
11. Weijenborg P.W., Rohof W.O., Akkermans L.M., et al. Electrical tissue impedance spectroscopy: a novel device to measure esophageal mucosal integrity changes during endoscopy. Neurogastroenterol Motil 2013, 25. 574-e458.
12. Jovov B., Que J., Tobey N.A., et al. Role of e-cdherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol 2011, 106:1039-1047.
13. Karabulut YY, Savas B, Kansu A, etal. Diagnosing oesophagitis in children: how discriminative is histology? Acta Gastroenterol Belg 2103;76:300-305.
14. van Rhijn B.D., Weijenborg P.W., Verheij J., et al. Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014, 12:1815-1823.
15. Katzka D.A., Tadi R., Smyrk T.C., et al. The effect of topical steroids on tight junction proteins and spongiosis in esophageal epithelia of patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014, 12:1824-1829.
16. Woddland P., Lee C., Duraisamy Y., et al. Assessment and protection of esophageal mucosal integrity in patients with heartburn without esophagitis. Am J Gastroenterol 2013, 108:535-543.