A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 10, 2014, Pages 994-999

  Zhang, Yikai ^a   Zheng, Shanyuan ^b   Ngai, Sai Ming ^b   Zheng, Wenjie ^a   Li, Jinying ^a   Chen, Tianfeng ^a   Zhong, Xueyun ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Glioma; Organoselenium compound; Selenium; Signal transduction

Indexed keywords

4 (BENZO[C][1,2,5]SELENADIAZOL 6 YL)BENZENE 1,2 DIAMINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; ORGANOSELENIUM DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG; 4-(BENZO(C)(1,2,5)SELENADIAZOL-6-YL)-BENZENE-1,2-DIAMINE; CASPASE; DIAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER INHIBITION; CELL CYCLE ARREST; CELL DEATH; CELL POPULATION; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; ENZYME ACTIVATION; GLIOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; G1 PHASE CELL CYCLE CHECKPOINT; GLIOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DIAMINES; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE CELL CYCLE CHECKPOINTS; GLIOMA; HUMANS; ORGANOSELENIUM COMPOUNDS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84908162520     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c14-00354     Document Type: Article

References (28)

1. Huebner J., Onkologe, 19, 970-982 (2013).
2. Conklin K. A., Nutrition and Cancer - an International Journal, 37, 1-18 (2000).
3. Newman D. J., Cragg G. M., J. Nat. Prod., 75, 311-335 (2012).
4. Hidalgo M., Rowinsky E. K., Oncogene, 19, 6680-6686 (2000).
5. Furnari F. B., Fenton T., Bachoo R. M., Mukasa A., Stommel J. M., Stegh A., Hahn W. C., Ligon K. L., Louis D. N., Brennan C., Chin L., DePinho R. A., Cavenee W. K., Genes Dev., 21, 2683-2710 (2007).
6. Westphal M., Lamszus K., Natl. Rev. Neurosci., 12, 495-508 (2011).
7. Ip C., Dong Y., Ganther H. E., Cancer Metastasis Rev., 21, 281-289 (2002).
8. Ganther H. E., Adv. Exp. Med. Biol., 492, 119-130 (2001).
9. Spallholz J. E., Palace V. P., Reid T. W., Biochem. Pharmacol., 67, 547-554 (2004).
10. Ip C., Thompson H. J., Zhu Z., Ganther H. E., Cancer Res., 60, 2882-2886 (2000).
11. Ip C., Hayes C., Budnick R. M., Ganther H. E., Cancer Res., 51, 595-600 (1991).
12. Abdulah R., Miyazaki K., Nakazawa M., Koyama H., J. Trace Elem. Med. Biol., 19, 141-150 (2005).
13. Ip C., el-Bayoumy K., Upadhyaya P., Ganther H., Vadhanavikit S., Thompson H., Carcinogenesis, 15, 187-192 (1994).
14. Guan M.-c., Tang W.-h., Xu Z., Sun J., Evid. Based Complement. Alternat. Med., 2014, 1-6 (2014).
15. L. Zhang, L. Zhou, J. Du, M. Li, C. Qian, Y. Cheng, Y. Peng, J. Xie, D. Wang, Biomed Research International (2014) in press.
16. El-Bayoumy K., Das A., Narayanan B., Narayanan N., Fiala E. S., Desai D., Rao C. V., Amin S., Sinha R., Carcinogenesis, 27, 1369-1376 (2006).
17. Ip C., Ganther H. E., Carcinogenesis, 13, 1167-1170 (1992).
18. Chen T., Wong Y.-S., Biomed. Pharmacother., 63, 105-113 (2009).
19. Luo Y., Li X., Huang X., Wong Y.-S., Chen T., Zhang Y., Zheng W., Chem. Pharm. Bull., 59, 1227-1232 (2011).
20. He J., Li D., Xiong K., Ge Y., Jin H., Zhang G., Hong M., Tian Y., Yin J., Zeng H., Bioorg. Med. Chem., 20, 3816-3827 (2012).
21. Spencer S. L., Sorger P. K., Cell, 144, 926-939 (2011).
22. Michaud W. A., Nichols A. C., Mroz E. A., Faquin W. C., Clark J. R., Begum S., Westra W. H., Wada H., Busse P. M., Ellisen L. W., Rocco J. W., Clin. Cancer Res., 15, 1645-1654 (2009).
23. Whibley C., Pharoah P. D., Hollstein M., Nat. Rev. Cancer, 9, 95-107 (2009).
24. Vousden K. H., Lu X., Nat. Rev. Cancer, 2, 594-604 (2002).
25. Tanel A., Averill-Bates D. A., Cell. Signal., 19, 968-977 (2007).
26. Gromer S., Gross J. H., J. Biol. Chem., 277, 9701-9706 (2002).
27. Marshall J. R., Nutr. Cancer, 40, 74-77 (2001).
28. Huang X.-C., Zheng J.-S., Chen T.-F., Zhang Y.-B., Luo Y., Zheng W.-J., Chemical Journal of Chinese Universities-Chinese, 33, 976-982 (2012).