Low expression of Mig-6 is associated with poor survival outcome in NSCLC and inhibits cell apoptosis via ERK-mediated upregulation of Bcl-2

Oncology Reports

Volumn 31, Issue 4, 2014, Pages 1707-1714

  Li, Zixuan ^a   Qu, Lianyue ^a   Zhong, Hongshan ^a   Xu, Ke ^a   Qiu, Xueshan ^a   Wang, Enhua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Mitogen inducible gene 6; NSCLC; P ERK

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; REGULATOR PROTEIN; SMALL INTERFERING RNA;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MIG 6 GENE; MITOGEN INDUCIBLE GENE 6; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84908148196     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3050     Document Type: Article

References (28)

1. Zhang YW, Vande Woude GF: Mig-6, signal transduction, stress response and cancer. Cell Cycle 6: 507-513, 2007.
2. Ogunbiyi OA, Goodfellow PJ, Gagliardi G, et al: Prognostic value of chromosome 1p allelic loss in colon cancer. Gastroenterology 113: 761-766, 1997.
3. Koshikawa K, Nomoto S, Yamashita K, Ishigure K, Takeda S and Nakao A: Allelic imbalance at 1p36 in the pathogenesis of human hepatocellular carcinoma. Hepatogastroenterology 51: 186-191, 2004.
4. Tseng RC, Chang JW, Hsien FJ, et al: Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer 117: 241-247, 2005.
5. Jeong JW, Lee HS, Lee KY, et al: Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci USA 106: 8677-8682, 2009.
6. Ferby I, Reschke M, Kudlacek O, et al: Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12: 568-573, 2006.
7. Zhang YW, Staal B, Su Y, et al: Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26: 269-276, 2007.
8. Jin N, Gilbert JL, Broaddus RR, Demayo FJ and Jeong JW: Generation of a Mig-6 conditional null allele. Genesis 45: 716-721, 2007.
9. Anastasi S, Sala G, Huiping C, et al: Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin. Oncogene 24: 4540-4548, 2005.
10. Anastasi S, Fiorentino L, Fiorini M, et al: Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene 22: 4221-4234, 2003.
11. Xu D, Makkinje A and Kyriakis JM: Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J Biol Chem 280: 2924-2933, 2005.
12. Anastasi S, Baietti MF, Frosi Y, Alema S and Segatto O: The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Oncogene 26: 7833-7846, 2007.
13. Amatschek S, Koenig U, Auer H, et al: Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Cancer Res 64: 844-856, 2004.
14. Li Z, Dong Q, Wang Y, Qu L, Qiu X and Wang E: Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling. Mol Carcinog 51: 522-534, 2012.
15. Wu S, Xing W, Peng J, et al: Tumor transfected with CCL21 enhanced reactivity and apoptosis resistance of human monocyte-derived dendritic cells. Immunobiology 213: 417-426, 2008.
16. Ling YH, Liebes L, Jiang JD, et al: Mechanisms of proteasome inhibitor PS-341-induced G2-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 9: 1145-1154, 2003.
17. Kim JW, Ferris RL and Whiteside TL: Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis. Clin Cancer Res 11: 7901-7910, 2005.
18. Faber AC, Li D, Song Y, et al: Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci USA 106: 19503-19508, 2009.
19. Liu Y, Yang Y, Ye YC, et al: Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. J Pharmacol Sci 118: 423-432, 2012.
20. Okamoto K, Okamoto I, Okamoto W, et al: Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Res 70: 10402-10410, 2010.
21. Lin CI, Du J, Shen WT, et al: Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer. J Clin Endocrinol Metab 96: E554-E565, 2011.
22. Reschke M, Ferby I, Stepniak E, et al: Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology 51: 1383-1390, 2010.
23. Ruan DT, Warren RS, Moalem J, et al: Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAFV600E positive papillary thyroid cancers. Surgery 144: 908-914, 2008.
24. Ying H, Zheng H, Scott K, et al: Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci USA 107: 6912-6917, 2010.
25. Kim TH, Franco HL, Jung SY, et al: The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene 29: 3770-3780, 2010.
26. Ewings KE, Wiggins CM and Cook SJ: Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels. Cell Cycle 6: 2236-2240, 2007.
27. Chen YR, Wang X, Templeton D, Davis RJ and Tan TH: The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271: 31929-31936, 1996.
28. Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.