Two recessive mutations in fgf5 are associated with the long-hair phenotype in donkeys

Genetics Selection Evolution

Volumn 46, Issue 1, 2014, Pages

  Legrand, Romain ^a   Tiret, Laurent ^a   Abitbol, Marie ^a  

^a ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; BREEDING POPULATION; DNA; HAIR; HETEROZYGOSITY; HORSE; MUTATION; NEW RECORD; PHENOTYPE; SELECTIVE BREEDING;

FIBROBLAST GROWTH FACTOR 5;

ALLELE; ANIMAL; EQUIDAE; FRAMESHIFT MUTATION; GENETIC POLYMORPHISM; GENETICS; HAIR; HORSE; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; RECESSIVE GENE;

ALLELES; ANIMALS; EQUIDAE; FIBROBLAST GROWTH FACTOR 5; FRAMESHIFT MUTATION; GENES, RECESSIVE; HAIR; HORSES; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, GENETIC;

EID: 84908140815     PISSN: 0999193X     EISSN: 12979686     Source Type: Journal    
DOI: 10.1186/s12711-014-0065-5     Document Type: Article

References (24)

1. Ozawa K, Suzuki S, Asada M, Tomooka Y, Li AJ, Yoneda A, Komi A, Imamura T: An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. J Biol Chem 1998, 273:29262-29271.
2. Beenken A, Mohammadi M: The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009, 8:235-253.
3. Zhan X, Bates B, Hu XG, Goldfarb M: The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol Cell Biol 1988, 8:3487-3495.
4. Hébert JM, Rosenquist T, Götz J, Martin GR: FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 1994, 78:1017-1025.
5. Suzuki S, Ota Y, Ozawa K, Imamura T: Dual-mode regulation of hair growth cycle by two Fgf-5 gene products. J Invest Dermatol 2000, 114:456-463.
6. Hattori Y, Yamasaki M, Itoh N: The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5. Biochim Biophys Acta 1996, 1306:31-33.
7. Sundberg JP, Rourk MH, Boggess D, Hogan ME, Sundberg BA, Bertolino AP: Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Vet Pathol 1997, 34:171-179.
8. Mizuno S, Iijima S, Okano T, Kajiwara N, Kunita S, Sugiyama F, Yagami K: Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair. Exp Anim 2011, 60:161-167.
9. Housley DJ, Venta PJ: The long and the short of it: evidence that FGF5 is a major determinant of canine 'hair'-itability. Anim Genet 2006, 37:309-315.
10. Dierks C, Mömke S, Philipp U, Distl O: Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. Anim Genet 2013, 44:425-431.
11. Kehler JS, David VA, Schäffer AA, Bajema K, Eizirik E, Ryugo DK, Hannah SS, O'Brien SJ, Menotti-Raymond M: Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats. J Hered 2007, 98:555-566.
12. Drögemüller C, Rüfenacht S, Wichert B, Leeb T: Mutations within the FGF5 gene are associated with hair length in cats. Anim Genet 2007, 38:218-221.
13. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C: Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature 2013, 499:74-78.
14. Untergasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, Remm M, Rozen SG: Primer3-new capabilities and interfaces. Nucleic Acids Res 2012, 40:e115.
15. Corpet F: Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 1988, 16:10881-10890.
16. Ahmadian A, Gharizadeh B, Gustafsson AC, Sterky F, Nyrén P, Uhlén M, Lundeberg J: Single-nucleotide polymorphism analysis by pyrosequencing. Anal Biochem 2000, 280:103-110.
17. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR: A method and server for predicting damaging missense mutations. Nat Methods 2010, 7:248-249.
18. Kelley LA, Sternberg MJ: Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc 2009, 4:363-371.
19. Musilova P, Kubickova S, Vahala J, Rubes J: Subchromosomal karyotype evolution in Equidae. Chromos Res 2013, 21:175-187.
20. Vidale P, Piras FM, Nergadze SG, Bertoni L, Verini-Supplizi A, Adelson D, Guérin G, Giulotto E: Chromosomal assignment of six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) in four species of the genus Equus. Anim Biotechnol 2011, 22:119-123.
21. Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G: Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 2009, 326:865-867.
22. McCue ME, Bannasch DL, Petersen JL, Gurr J, Bailey E, Binns MM, Distl O, Guerin G, Hasegawa T, Hill EW, Leeb T, Lindgren G, Penedo MC, Røed KH, Ryder OA, Swinburne JE, Tozaki T, Valberg SJ, Vaudin M, Lindblad-Toh K, Wade CM, Mickelson JR: A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies. PLoS Genet 2012, 8:e1002451.
23. Mohammadi M, Olsen SK, Ibrahimi OA: Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev 2005, 16:107-137.
24. Goetz R, Mohammadi M: Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol 2013, 14:166-180.