Synthesis of stimuli-sensitive copolymers by RAFT polymerization: Potential candidates as drug delivery systems

Materials Research

Volumn 17, Issue , 2014, Pages 191-196

  Tebaldi, Marli L ^a   Leal, Debora Abrantes ^a   Montoro, Sergio R ^b   Petzhold, Cesar ^c  

^a FEDERAL UNIVERSITY OF ITAJUBÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Poly(dimethylaminoethyl methacrylate); Poly(methylmethacrylate); Poly(vinylcaprolactam); Reversible addition fragmentation chain transfer (RAFT) polymerization

Indexed keywords

BLOCK COPOLYMERS; LIVING POLYMERIZATION; MEDICAL APPLICATIONS; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; POLYMETHYL METHACRYLATES;

2-(DIMETHYLAMINO)ETHYL METHACRYLATE; 2-CYANOPROP-2-YL DITHIOBENZOATE; 2-ETHYLMETHACRYLATE(DIMETHYLAMINO); BIOMEDICAL APPLICATIONS; CHAIN TRANSFER AGENTS; DIMETHYLAMINOETHYL METHACRYLATES; POLY(VINYLCAPROLACTAM); REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION;

DRUG DELIVERY;

EID: 84908120152     PISSN: 15161439     EISSN: 19805373     Source Type: Journal    
DOI: 10.1590/S1516-14392014005000033     Document Type: Article

References (19)

1. Grainger SJ and El-Sayed MEH. Stimuli-Sensitive Particles for Drug Delivery. Biologically-Responsive Hybrid Biomaterials. 2010; 171-190.
2. Aguilar MR, Elvira C, Gallardo A, Vázquez B and Román JS. Smart Polymers and Their Applications as Biomaterials. Topics in Tissue Engineering. 2007; 3(6).
3. Sousa JCP, Naves AF and Florenzano FH. Specific thermoresponsiveness of PMMA-block-PDMAEMA to selected íons and factors in aqueous solution. Colloid polymer Science. 2012; 290:1285-1291. http://dx.doi.org/10.1007/s00396-012-2651-9
4. Tebaldi MLS, Chaparro TC and Santos AM. Tri-block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-delivery Systems. Materials Science Forum. 2010; 636-637:76-81. http://dx.doi.org/10.4028/www.scientific.net/MSF.636-637.76
5. Moshaverinia A, Roohpour N, Darr JA and Rehman IU. Synthesis and characterization of a novel N-vinylcaprolactam-containing acrylic acid terpolymer for applications in glass-ionomer dental cements. Acta Biomaterialia. 2009; 5:2101-2108. http://dx.doi.org/10.1016/j.actbio.2009.02.015
6. Braunecker WA and Matyjaszewski K. Controlled/living radical polymerization: Features, developments, and perspectives. Progress in Polymer. 2007; 32:93-146. http://dx.doi.org/10.1016/j.progpolymsci.2006.11.002
7. Amin A. Amphiphilic Star Homo- and Block Copolymers of 2-(dimethylamino) Ethyl-Methacrylate via Atom Transfer Radical Polymerization. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2007; 44:329-335. http://dx.doi.org/10.1080/10601320601077542
8. Kowollik CB and Perrier S. The Future of Reversible Addition Fragmentation Chain Transfer Polymerization. Journal of Polymer Science Part A: Polymer Chemistry. 2008; 46:5715-5723. http://dx.doi.org/10.1002/pola.22866
9. Xiao G, Hu Z, Zeng G, Wang Y, Huang Y, Hong X et al. Effect of Hydrophilic Chain Length on the Aqueous Solution Behavior of Block Amphiphilic Copolymers PMMA-b-PDMAEMA. Journal of Applied Polymer Science. 2012;124:202-208. http://dx.doi.org/10.1002/app.33734
10. San Miguel V, Limer AJ, Haddleton DM, Catalina F and Peinado C. Biodegradable and thermoresponsive micelles of triblock copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and e-caprolactone for controlled drug delivery. European Polymer Journal. 2008; 44:3853-3863. http://dx.doi.org/10.1016/j.eurpolymj.2008.07.056
11. Tian Z, Liu X, Chen C and Allcock HR. Synthesis and Micellar Behavior of Novel AmphiphilicPoly[bis(trifluoroethoxy) phosphazene]-co-poly[(dimethylamino)ethyl methacrylate] Block Copolymers. Macromolecules. 2012; 45:2502-2508. http://dx.doi.org/10.1021/ma300139z
12. Zhu YJ, Tan YB and Du X. Preparation and self-assembly behavior of polystyrene-block-poly (dimethylaminoethyl methacrylate) amphiphilic block copolymer using atom transfer radical polymerization. eXPRESS Polymer Letters. 2008; 2(3):214-225. http://dx.doi.org/10.3144/expresspolymlett.2008.26
13. Manganiello MJ, Cheng C, Convertine AJ, Bryers JD and Stayton PS. Diblock copolymers with tunable pH transitions for gene delivery. Biomaterials. 2012; 33:2301-2309. http://dx.doi.org/10.1016/j.biomaterials.2011.11.019
14. Wan D, Zhou Q, Pu H and Yang G. Controlled radical polymerization of N-vinylcaprolactam mediated by xanthate or dithiocarbamate. Journal of Polymer Science: Part A: Polymer Chemystry. 2008; 3756-3765.
15. Shao L, Hu M, Chen L, Xu L and Bi Y. RAFT polymerization of N-vinylcaprolactam and effects of the end group on the thermal response of poly(N-vinylcaprolactam). Reactive & Functional Polymers. 2012;72:407-413. http://dx.doi.org/10.1016/j.reactfunctpolym.2012.04.002
16. Fournier D, Hoogenboom R, Hanneke ML, Thijs RMP and Schubert US. Tunable pH- and Temperature-Sensitive Copolymer Libraries by Reversible Addition-Fragmentation Chain Transfer Copolymerizations of Methacrylates. Macromolecules. 2007; 40:915-920. http://dx.doi.org/10.1021/ma062199r
17. Tebaldi MLT, Riegel IC, Ceschi MA, Müller AHE and Cesar LP. Synthesis of block copolymers based on poly(2,3-epithiopropylmethacrylate) via RAFT polymerization and preliminary investigations on thin film formation. European Polymer Journal. 2010; 46:336-344. http://dx.doi.org/10.1016/j.eurpolymj.2009.09.017
18. Tebaldi MLS, Silva EO, Ceschi MA and Cesar LP. Synthesis and radical polymerization of bifunctionalized aziridinic methacrylates. Reactive & Functional Polymers. 2011; 71:648-654. http://dx.doi.org/10.1016/j.reactfunctpolym.2011.02.005
19. Hu L, Chu LY, Yang M, Wang HD and Niu CH. Preparation and characterization of novel cationic pH-responsive poly(N,Ndimethylamino ethyl methacrylate) microgels. Journal of Colloid and Interface Science. 2007; 311:110-117. http://dx.doi.org/10.1016/j.jcis.2007.02.063