A review on the pharmacological aspects of Terminalia chebula

International Journal of Pharmacology

Volumn 10, Issue 6, 2014, Pages 289-298

  Upadhyay, Aparna ^a   Agrahari, Pooja ^a   Singh, D K ^a  

^a D D U GORAKHPUR UNIVERSITY   (India)

Author keywords

Pharmacology; Phytochemistry; Tannin; Terminalia chebula; Triphala

Indexed keywords

2,4 CHEBULYL D GLUCOPYRANOSE; ARJUNGENIN; ARJUNGLUCOSIDE 1; CHEBULIN; CHEBULINIC ACID; ELLAGIC ACID; ETHYL GALLATE; GALLIC ACID; HERBACEOUS AGENT; LUTEOLIN; PLANT MEDICINAL PRODUCT; PUNICALAGIN; TANNIN; TERCHEBIN; TERFLAVIN A; TERMINALIA CHEBULA EXTRACT; TRIPHALA; UNCLASSIFIED DRUG;

ANAPHYLACTIC ACTIVITY; ANTI ULCEROGENIC ACTIVITY; ANTIARTHRITIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTICARCINOGENIC ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARDIOPROTECTIVE ACTIVITY; CARDIOVASCULAR DISEASE; CYTOPROTECTIVE ACTIVITY; DIABETES MELLITUS; EPILEPSY; GASTROINTESTINAL DISEASE; GEOGRAPHICAL VARIATION (SPECIES); HEPATOPROTECTIVE ACTIVITY; IMMUNOMODULATION; MOLLUSCICIDAL ACTIVITY; NEUROPROTECTIVE ACTIVITY; NONHUMAN; PROKINETIC ACTIVITY; RENOPROTECTIVE ACTIVITY; RESPIRATORY TRACT DISEASE; SKIN INFECTION; URINARY TRACT DISEASE; WOUND HEALING;

EID: 84908099007     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2014.289.298     Document Type: Article

References (74)

1. Ahmad, I., Z. Mehmood and F. Mohammad, 1998. Screening of some Indian medicinal plants for their antimicrobial properties. J. Ethnopharmacol., 62: 183-193.
2. Ahn, M.J., C.Y. Kim, J.S. Lee, T.G. Kim and S.H. Kim etal, 2002. Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Plant. Med., 68: 457-459.
3. Arora, S., K. Kaur and S. Kaur, 2003. Indian medicinal plants as a reservoir of protective phytochemicals. Teratogenesis Carcinogenesis Mutagenesis, 1: 295-300.
4. Badmaev, V. and M. Nowakowski, 2000. Protection of epithelial cells against influenza a virus by a plant derived biological response modifier Ledretan-96. Phytotherapy Res., 14: 245-249.
5. Barthakur, N.N. and A.P. Arnold, 1991. Nutritive value of the chebulic myrobalan Terminalia chebula Retz. and its potential as a food source. Food Chem., 40: 213-219.
6. Bruneton, J., 1995. Pharmacognosy, Phytochemistry, Medicinal Plants. Laviosier Publishing, Paris, France, Pages: 333.
7. Chang, C.L. and C.S. Lin, 2010. Development of anti oxidant activity and pattern recognition of Terminalia chebula Retzius extracts and its fermented products. Hung Kuang J., 61: 115-129.
8. Chang, C.L. and C.S. Lin, 2011. Phytochemical composition, anti oxidant activity and neuroprotective effect of Terminalia chebula Retzius extracts. Evid.-Based Complementary Altem. Med., Vol. 2012. 10.1155/2012/125247
9. Chattopadhyay, R.R. and S.K. Bhattachaiyya, 2007. PHCOGREV.: Plant review Terminalia chebula. An update. Pharmacog. Rev., 1: 151-156.
10. Cheng, H.Y., T.C. Lin, K.H. Yu, C.M. Yang and C.C. Lin, 2003. Antioxidant and free radical scavenging activities of Terminalia chebula. Biol. Pharm. Bull., 26: 1331-1335.
11. Chevallier, A., 1996. The Encyclopedia of Medicinal Plants. D.K. Publishing, New York, ISBN: 9780789410672, Pages: 336.
12. Chopra, R.N., S.L. Nayar and l.C. Chopra, 1956. Glossary of Indian Medicinal Plants. CSIR, New Delhi, India.
13. Creencia, E.C., T. Eguchi, T. Nishimura and K. Kakinuma, 1996. Isolation and structure elucidation of the biologically active components of Terminalia chebula Retzius (Combretaceae). KIMIKA, 12: 1-10.
14. Dastur, J.F., 1962. Medicinal Plants of India and Pakistan. D.B. Taraporevala Sons and Co. Pvt. Ltd., Bombay, pp: 162-163.
15. Debnath, J., U.R. Sharma, B. Kumar and N.S. Chauhan, 2010. Anticonvulsant activity of ethanolic extract of fruits of Terminalia chebula on experimental animals. Int. J. Drug Dev. Res., 2: 764-768.
16. Dev, S., 2005. A Selection of Prime Ayurvedic Plant Drugs. Anamaya Publishers, New Delhi, pp: 410-416.
17. Dutta, B.K., I. Rahman and T.K. Das, 1998. Antifungal activity of Indian plant extracts: Antimyzetische Aktivitat indischer Pflanzenextrakte. Mycoses, 41: 535-536.
18. Evans, W., 1996. Trease and Evan’s Pharmacology. 14thEdn., W.B. Saunders Co. Pvt. Ltd., Philadelphia, Pages: 493.
19. Hamada, S., T. Kataoka, J.T. Wo, A. Yamada and T. Yoshida et al., 1997. Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity. Biol. Pharm. Bull., 20: 1017-1019.
20. Hasani-Ranjbar, S., H. Vahidi, S. Taslimi, N. Karimi, B. Larijani and M. Abdollahi, 2010. A systematic review on the efficacy of herbal medicines in the management of human drug-induced hyperprolactinemia: Potential sources for the development of novel drugs. Int. J. Pharmacol., 6: 691-695.
21. Jagtap, A.G. and S.G. Karkera, 1999. Potential of the aqueous extract of Terminalia chebula as an anticaries agent. J. Ethnopharmacol., 68: 299-306.
22. Juang, L.J., S J. Sheu and T.C. Lin, 2004. Determination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresis. J. Sep. Sci.,27: 718-724.
23. Kannan, P., S.R. Ramadevi and W. Hopper, 2009. Antibacterial activity of Terminalia chebula fruit extract. Afr. J. Microbiol. Res., 3: 180-184.
24. Kapoor, L.D., 1990. CRC Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Ralon, Pages: 332.
25. Khazaeli, P., R. Goldoozian and F. Sharififar, 2009. An evaluation of extracts of five traditional medicinal plants from Iran on the inhibition of mushroom tyrosinase activity and scavenging of free radicals. Int. J. Cosmetic Sci., 31: 375-381.
26. Kim, H.G., J.H. Cho, E.Y. Jeong, J.H. Lim, S.H. Lee and H.S. Lee, 2006. Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria. J. Food Prot., 69: 2205-2209.
27. Kokate, C.K., A.P. Purohit and S.B. Gokhale, 2001. Pharmacognosy. 12th Edn., Nirali Prakashan, Pune, pp: 216-217.
28. Krishnan, K.S., 1998. The wealth of India. Raw Mater., 10: 171-171.
29. Kumar, K.J., 2006. Effect of geographical variation on contents of tannic acid, gallic acid, chebulinic acid and ethyl gallate in Terminalia Chebula fruits. Nat Prod., 2: 170-175.
30. Kundu, A.K. and S.B. Mahato, 1993. Triterpenoids and their glycosides from Terminalia chebula. Phytochemistry, 32: 999-1002.
31. Kurokawa, M., K. Nagasaka, T. Hirabayashi, S. Uyama and H. Sato et al., 1995. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res., 27: 19-37.
32. Lee, H.S., H.Y. Cho, K.W. Park, I.H. Kim, J.T. Kim, M.H. Nam and K.W. Lee, 2011. Inhibitoiy effects of Terminalia chebula extract on gly cation and endothelial cell adhesion. Planta Med.-Nat. Prod. Med. Plant Res.,77: 1060-1067.
33. Lee, H.S., N.H. Won, K.H. Kim, H. Lee, W. Jun and K.W. Lee, 2005. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol. Pharm. Bull., 28: 1639-1644.
34. Lee, H.S., S.H. Jung, B.S. Yun and K.W. Lee, 2007. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch. Toxicol., 81: 211-218.
35. Malekzadeh, F., H. Ehsanifar, M. Shahamat, M. Levin and R.R. Colwell, 2001. Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. Int. J. Antimicrob. Agents, 18: 85-88.
36. Maruthappan, V. and K.S. Shree, 2010. Hypolipidemic activity of Haritaki (Terminalia chebula) in atherogenic diet induced hyperlipidemic rats. J. Adv. Pharm. Technol. Res., 1: 229-235.
37. Mostafa, M.G., M. Rahman and M.M. Karim, 2011. Antimicrobial activity of Terminalia chebula. Int. J. Med. Aromatic Plants, 1: 175-179.
38. Na, M., K. Bac, S.S. Kang, B.S. Mm and J.K. Yoo et al.,2004. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit. Phytother. Res., 18: 737-741.
39. Nadkami, K.M., 1976. Indian Material Medica. Popular Prakashan Pvt. Ltd., Bombay, pp: 1202-1211.
40. Naik, G.H., K.I. Priyadarsini, D.B. Naik, R. Gangabhagirathi and H. Mohan, 2004. Studies on the aqueous extract of Terminalia chebula as a potent anti oxidant and a probable radioprotector. Phytomedicine, 11: 530-538.
41. Nair, V., S. Singh and Y.K. Gupta, 2010. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. J. Pharm. Pharmacol., 62: 1801-1806.
42. Paarakh, P.M., L.J. Patil and S.A. Thanga, 2008. Genus salacia: A comprehensive review. J. Nat. Remedies, 8: 116-131.
43. Panthi, M.P. and R.P. Chaudhary, 2006. Antibacterial activity of some selected folklore medicinal plants from West Nepal. Scient. World, 4: 16-21.
44. Phadke, S.A. and S.D. Kulkami, 1989. Screening of in vitro antibacterial activity of Terminalia chebula, Eclapta alba and Ocimum sanctum. Indian J. Med. Sci.,43: 113-117.
45. Philipson, J.D., 1990. Plants as a Source of Valuable Products. In: Secondary Products from Plants Tissue Culture, Chari wood, B.V. and M.J. Rhodes (Eds.). Clarendon Press, Oxford, pp: 1 -22.
46. Qaisar, N., B.A. Chaudhary, A. Dasti, A. Malik and R. Zafar, 2009. Phytochemical study of aerial parts of Lantana camara for the pharmacological active compounds. J. Applied Pharm., 1: 19-26.
47. Raju, D., K. Ilango, V. Chitra and K. Ashish, 2009. Evaluation of anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats. J. Pharma. Sci. Res., 1: 101-107.
48. Rani, P. and N. Khullar, 2004. Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. Phytother. Res., 18: 670-673.
49. Rao, N.K. and S. Nammi, 2006. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complementary Altem. Med., Vol. 6. 10.1186/1472- 6882-6-17
50. Ray, P.G. and S.K. Majumdar, 1976. Antimicrobial activity of some Indian plants. Econ. Bot., 30: 317-320.
51. Reddy, V.R.C., S. V.R. Kumari, B.M. Reddy, M.A. Azeem, M.C. Prabhakar and A.V.N.A. Rao, 1990. Cardiotonic activity of the fruits of Terminalia chebula. Fitoterapia, 41: 517-525.
52. Rege, N.N., U.M. Thatte and S.A. Dahanukar, 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother. Res., 13: 275-291.
53. Sabu, M.C. and R. Kuttan, 2002. Anti-diabetic activity of medicinal plants and its relationship with their anti oxidant property. J. Ethanopharmacol., 81: 155-160.
54. Saha, P.K., P.H. Patra, R. Pradhan, R. Dey, S. Das and T.K. Mandal, 2011. Effect of Termialia chebula and Terminalia bellerica on wound healing induced dermal wounds in rabbits. Pharmacology online, 2: 235-241.
55. Saleem, A., M. Ahotupa and K. Pihlaja, 2001. Total phenolics concentration and antioxidant potential of extracts of medicinal plants of Pakistan. Z. Naturforsch., 56C: 973-978.
56. Saleem, A., M. Husheem, P. Harkonen and K. Pihlaja, 2002. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit. J. Ethnopharmacol., 81: 327-336.
57. Sandeep, C. and M.P. Padmaa, 2009. Jasminum grandiflorum SLinn. (Chameli): Ethnobotany, phytochemistry and pharmacology: A review. Pharmacol. Newslett., 2: 586-595.
58. Sato, Y., H. Oketani, K. Singyouchi, T. Ohtsubo, M. Kihara, H. Shibata and T. Higuti, 1997. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillin-resistant Staphylococcus aureus. Biol. Pharm. Bull., 4: 401-404.
59. Sharma, P., T. Prakash, D. Kotresha, M.A. Ansari and U.R. Sahrm et al., 2011. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm. Biol., 49: 262-268.
60. Sharma, P. V., 1995. Dravya Guna Vigyana by Priya Vrita Sharma. Chaukhamba Bharati Acad., 2: 753-758.
61. Sharma, R. and V. Aiya, 2011. A review on fruits having anti-diabetic potential. J. Chem. Pharm. Res., 3: 204-212.
62. Shin, T.Y., H.J. Jeong, D.K. Kim, S.H. Kim and J.K. Lee et al., 2001. Inhibitoiy action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis. J. Ethnopharmacol., 74: 133-140.
63. Singh, D.K. and R.A. Agarwal, 1983. In vivo and in vitro studies on synergism with anticholinesterase pesticides in the snail Lymnaea acuminate. Arch. Environ. Contain. Toxicol., 12: 483-487.
64. Singh, N., R. Nath, N. Mishra and R.P. Kohli, 1978. An experimental evaluation of anti-stress effects of geriforte (an ayurvedic drug). Pharm. Biol., 16: 125-136.
65. Suchalatha, S. and C.S. Shyamala Devi, 2004. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Int. J. Exp. Biol., 42: 174-178.
66. Tambekar, D.H., B.S. Khante, S.B. Dahikar and Y.S. Banginwar, 2007. Antibacterial properties of contents of Triphala: A traditional Indian herbal preparation. Continental J. Microbiol., 1: 8-12.
67. Tamhane, M.D., S. P. Thorat, N.N. Rege and S.A. Dahanukar, 1997. Effect of oral administration of Terminalia chebula on gastric emptying: An experimental study. J. Postgrad. Med., 43: 12-13.
68. Tasduq, S.A., K. Singh, N.K. Satti, D.K. Gupta, K.A. Suri and R.K. Johri, 2006. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum. Exp. Toxicol., 25: 111-118.
69. Thomas R., R. Tripathi, S.D. Kamatand, D.V. Kamat, 2012. Comparative study of phenolics and anti oxidant activity of phytochemicals of T. chebula extracted using microwave and ultrasonication. Int. J. Pharm. Sci. Res.,3: 194-197.
70. Upadhyay, A. and D.K. Singh, 2011a. Inhibition kinetics of certain enzymes in the nervous tissue of vector snail Lymnaea acuminata by active molluscicidal components of Sapindus mukorossi and Terminalia chebula. Chemosphere, 85: 1095-1100.
71. Upadhyay, A. and D.K. Singh, 2011b. Molluscicidal activity of Sapindus mukorossi and Terminalia chebula against the freshwater snail Lymnaea acuminata. Chemosphere, 83: 468-474.
72. Vermani, K. and S. Garg, 2002. Herbal medicines for sexually transmitted diseases and AIDS. J. Ethnopharmacol., 80: 49-66.
73. Vonshak, A., O. Barazani, P. Sathiyamoorthy, R. Shalev, D. Vardy and A. Golan-Goldhirsh, 2003. Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother. Res., 17: 1123-1125.
74. Yukawa, T.A., M. Kurokawa, H. Sato, Y. Yoshida and S. Kageyama et al., 1996. Prophylactic treatment of cytomegalovirus infection with traditional herbs. Antiviral Res., 32: 63-70.